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scpA from Streptococcus pyogenes MGAS2096

Victor ID 4394
Gene Name scpA from Streptococcus pyogenes MGAS2096
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS2096
NCBI Gene ID 4064563
NCBI Protein GI 94993241
Locus Tag MGAS2096_Spy1744
Protein Accession YP_601340.1
Other Database IDs UniProtKB-ID: Q1J9L5_STRPB
UniRef100: UniRef100_P15926
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00001355FB
EMBL: CP000261
EMBL-CDS: ABF36796.1
RefSeq_NT: NC_008023.1
EnsemblGenome: EBSTRG00000044436.
EnsemblGenome_TRS: EBSTRT00000044443
EnsemblGenome_PRO: EBSTRP00000042749
GenomeReviews: CP000261_GR
KEGG: spj:MGAS2096_Spy1744
eggNOG: COG1404
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO370553:MGAS2096_SPY1744-MONOMER
Taxonomy ID 370553
Gene Starting Position 1694020
Gene Ending Position 1697523
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|94991497:1694020-1697523 Streptococcus pyogenes MGAS2096 chromosome, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAAGATATGAGCTACTAATCCAAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGAGCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTG
ACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCT
GGTTTAGCTTCTGGTTTTTTATCTGGTGTTTGACCTGAACCGTCTTGTTCTGGCTTATTAGAGTGGCCCT
CCAATAGCTTAGTCACTGGTGTATAAGTGATATTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGA
CATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCA
TTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAA
CCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGT
TGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAACTA
ATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGT
CCCAACGAGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAAC
TTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTA
GCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAG
CATATGGCTCGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACC
TGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCC
TTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTGTTTTTCAGAGCGTAAAACTGTA
ATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCT
ATCATAGATTGGTTTTTCTACGGCTGACAGATTGCCAAAATCACCTCGGAAACCAATATATGGAATGCTC
ATAAGCTCTTCTTTTGTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTT
GGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTGGCTGG
AATTGTGATTTTTTGCCATGATGCCTCATACAATACTTTAGGAGCCAAGGCAAAGTGTTTTCCATCTACT
TTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACAGTTACTG
TTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTCACATA
CATCGTTGCTGCTGAAGCTTTTTTAGCATCGACCGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCT
TTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTG
ATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAACAGTCCCATGATACCCGCTACTAATGG
CGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCG
GGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGG
TGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTGGGGATTGTCTTTTAA
TAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATTTGGCAATTCAATCGGGAAG
CCCTTGTCCTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTTTTTAGCGTTTGCAACCTTATCTT
TGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTGCCTTTGACATCCTTAAAATCATCCTCTTTCAT
CCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATT
TCTTTATCTTGCTGATCGTCTGTTTTGACCATAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAG
CAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGG
TAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTG
GCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGGAGGTTAGCGTAGGCTAGTGCAGCATTACCAAAGCTCA
TATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGTAGTTACGAGCATAGTCTGC
TAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAA
GGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGA
CAGCGGTTTTACCATCTTTGCTATAGTCGTGGTAATAAGCAACCTTATCATTGACCCACTCGCCATAGGT
AATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTGGTTTTGTCTGTT
AAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCCTTGC
CTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAGGTTGC
TGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCGTCATCTGCTATTGTTTCTTCT
GCGTCATCAGGAGTTTGTGGGGTTTTGGTTTCCTTTGATGATGGTACTTCCTCAGAAACCGCTGTTGGTT
GTGGGGTTTCTACGGCTTGTTCGGTAACAGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTG
TGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAATGGTAATTTTTGTTTTTTA
CGCA
Protein Sequence 
>gi|94993241|ref|YP_601340.1| C5A peptidase [Streptococcus pyogenes MGAS2096] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPVTEQAVETPQPTAVSEEVPSSKETKTPQTPDDAEETIADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAMVKTDDQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKVANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKVLYEASWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSAVEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGEPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSGQTPDKKPEAKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].