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speB from Streptococcus pyogenes NZ131

Victor ID 4442
Gene Name speB from Streptococcus pyogenes NZ131
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985296
NCBI Protein GI 209560166
Locus Tag Spy49_1690c
Protein Accession YP_002286638.1
Other Database IDs UniProtKB-ID: B5XIU4_STRPZ
UniRef100: UniRef100_B5XIU4
UniRef90: UniRef90_P68884
UniRef50: UniRef50_P68884
UniParc: UPI000181F3F3
EMBL: CP000829
EMBL-CDS: ACI61943.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000050397.
EnsemblGenome_TRS: EBSTRT00000050405
EnsemblGenome_PRO: EBSTRP00000060126
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_1690c
HOGENOM: HBG703122
OMA: WESQIDK
ProtClustDB: CLSK698945
Taxonomy ID 471876
Gene Starting Position 1675303
Gene Ending Position 1676499
Gene Strand (Orientation) -
Protein Name Strepotococcal cysteine protease (Streptopain) / Streptococcal pyrogenic exotoxin B (SpeB)
DNA Sequence 
>gi|209558587:1675303-1676499 Streptococcus pyogenes NZ131 chromosome, complete genome
ACTAAGGTTTGATGCCTACAACAGCACTTTGGTAACCGTTGAAGCCGCCTGCGCCGCCACCAGTACCAAG
AGCTGAAGGGTTTAGTGCGTCAAGACGGAAGAAGCCGTCAGAGACTCCACCCCAACCCCAGTTAACATGG
TAGAAGTTACGTCCGTCAGCACCATCGATAACAAAGGCATGTCCGCCTACTTTACCGACACCTTGGTAGT
ATACTGGTTGGTTTTGAGATAATTCTTTGTCAATTTGTGATTCCCAATCTTGTTTGCTAAAGTCACTACG
GTTGATTTGGTGAACAGATTGGTTGTAGCCAAAGTTTTCTTTCAAGGCTCTTTGAACACGAGAGCTACCT
GCAGAACCACTAGATGGACCATAATCCATGTCTACTGAAATACCAACATCAGCCATCAATTCTGAAATCG
CCATTTTTTGAACGTTAGATTCTCTTCCGCTATAAGTAGGTAGGATGTTGTTCCAGTTGTATTGTCTAGT
AGAGATAGCTGCAAACAAGTTCTTAGGATGGTTGAAATATGGGTTATTTGAGCTTAGTGTGTAAGTGTAG
TCTTTCAACCCTTTGTTAGGGTAATTATGATATTTCATAATTTGAGCAGTTGCAGTAGCAACACATCCTG
TAGCTGCATGTTGACCTACAAAAGATTGTTCACCTGGTTTTACTTTTTCAATAACAGGTGTCAATAGGTT
GTAAGGGTTACCTTGATTGTAATGAATGCCTTTTGAATCAAGGAGAGATTTAACAACTGGTTGTTTAATC
TCAGCGGTACCAGCAAAAAGGGGGACTAATTTTTTGGTTTCTTTGATTTGGTCGACATAACTTTCCATGA
AGGAAGCAATGTTTTCTTTACCGTTAACGTCAAATGATCCGCTGGTAGAGTATCCTAGAATTTCTGGAGA
ACGTTTATCTCCTGAAACGATAACAAATCCTCCAGTAGAAATATTGTAAACATACATATTAGAGCCAGAA
AGTTCTCCACCTAAGTTAACTTTGTCAAGCTTAATATCTTCTGCGCTTCGTGCACCTGCTTTGATAGCTG
CTGATTTTTGGATAAATGTGATAGCGCTATCTTGTGCTTCTTTTTCGTTACGAGCAAAGTTTTGATCGGC
AAATACTGGGTTAGCAAGAACAAATCCACCTAATGCTAAAAGACTTAATAATCTGATACCTAATTTCTTT
TTATTCA
Protein Sequence 
>gi|209560166|ref|YP_002286638.1| strepotococcal cysteine protease (streptopain) / streptococcal pyrogenic exotoxin B (SpeB) [Streptococcus pyogenes NZ131] MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAQDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDVNGKENIASFMESYVDQIKETKKLVPLFAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWESQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008).
References
Chiang-Ni and Wu, 2008: Chiang-Ni C, Wu JJ. Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. Journal of the Formosan Medical Association = Taiwan yi zhi. 2008; 107(9); 677-685. [PubMed: 18796357].