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speB from Streptococcus pyogenes MGAS315

Victor ID 4333
Gene Name speB from Streptococcus pyogenes MGAS315
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1010057
NCBI Protein GI 21911278
Locus Tag SpyM3_1742
Protein Accession NP_665546.1
Other Database IDs UniProtKB-ID: SPEB_STRP3
UniRef100: UniRef100_P68884
UniRef90: UniRef90_P68884
UniRef50: UniRef50_P68884
UniParc: UPI000000B120
EMBL: L26146
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAA27012.1
EMBL-CDS: AAM80349.1
EMBL-CDS: BAC64834.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000034197
EnsemblGenome_TRS: EBSTRT00000034197
EnsemblGenome_PRO: EBSTRP00000032936
EnsemblGenome: EBSTRG00000036126
EnsemblGenome_TRS: EBSTRT00000036126
EnsemblGenome_PRO: EBSTRP00000034776
Genome
Taxonomy ID 198466
Gene Starting Position 1761397
Gene Ending Position 1762593
Gene Strand (Orientation) -
Protein Name pyrogenic exotoxin B
DNA Sequence 
>gi|21909536:1761397-1762593 Streptococcus pyogenes MGAS315 chromosome, complete genome
ACTAAGGTTTGATGCCTACAACAGCACTTTGGTAACCGTTGAAGCCGCCTGCGCCGCCACCAGTACCAAG
AGCTGAAGGGTTTAGTGCGTCAAGACGGAAGAAGCCGTCAGAGACTCCACCCCAACCCCAGTTAACATGG
TAGAAGTTACGTCCGTCAGCACCATCGATAACAAAGGCATGTCCGCCTACTTTACCGACACCTTGGTAGT
ATACTGGTTGGTTTTGAGATAATTCTTTGTCAATTTGTGCTTCCCAATCTTGTTTGCTAAAGTCGCTACG
GTTGATTTGGTGAACAGATTGGTTGTAGCCAAAGTTTTCTTTCAAGGCTCTTTGAACACGAGAGCTACCT
GCAGAACCACTAGATGGACCATAATCCATGTCTACTGAAATACCAACATCAGCCATCAATTCTGAAATCG
CCATTTTTTGAACGTTAGATTCTCTTCCGCTATAAGTAGGTAGGATGTTGTTCCAGTTGTATTGTCTAGT
AGAGATAGCTGCAAACAAGTTCTTAGGATGGTTGAAATATGGGTTATTTGAGCTTAGTGTGTAAGTGTAG
TCTTTCAACCCTTTGTTAGGGTAATTATGATATTTCATAATTTGAGCAGTTGCAGTAGCAACACATCCTG
TAGCTGCATGTTGACCTACAAAAGATTGTTCACCTGGTTTTACTTTTTCAATAACAGGTGTCAATAGGTT
GTAAGGGTTACCTTGATTGTAATGAATGCCTTTTGAATCAAGGAGAGATTTAACAACTGGTTGTTTAATC
TCAGCGGTACCAGCATAAGTAGTGTCTAATTTTTTGTTTTCTTTGATTTGTTCGACATAACTTTCCATGA
AGGAAGCAATGTTTTCTTTACCGTTAGCGTCAAATGATCCGCTGGTAGAGTATCCTAGAATTTCTGGAGA
ACGTTTATCTCCTGAAACGATAACAAATCCTCCAGTAGAAATATTGTAAACATACATATTAGAGCCAGAA
AGTTCTCCACCTAAGTTAACTTTGTCAAGCTTAATATCTTCTGCGCTTCGTGCACCTGCTTTGATAGCTG
CTGATTTTTGGATAAATGTGATAGCGCTATCTTTTGCTTCTTTTTCGTTACGAGCAAAGTTTTGATCGGC
AAATACTGGGTTAGCAAGAACAAATCCACCTAATGCTAAAAGACTTAATAATCTGATACCTAATTTCTTT
TTATTCA
Protein Sequence 
>gi|21911278|ref|NP_665546.1| pyrogenic exotoxin B [Streptococcus pyogenes MGAS315] MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008).
References
Chiang-Ni and Wu, 2008: Chiang-Ni C, Wu JJ. Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. Journal of the Formosan Medical Association = Taiwan yi zhi. 2008; 107(9); 677-685. [PubMed: 18796357].