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speJ from Streptococcus pyogenes MGAS6180

Victor ID 4350
Gene Name speJ from Streptococcus pyogenes MGAS6180
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS6180
NCBI Gene ID 3573258
NCBI Protein GI 71903011
Locus Tag M28_Spy0345
Protein Accession YP_279814.1
Other Database IDs UniProtKB-ID: Q48UZ7_STRPM
UniRef100: UniRef100_Q48UZ7
UniRef90: UniRef90_Q7BAE3
UniRef50: UniRef50_Q7BAE3
UniParc: UPI000057BC5A
EMBL: CP000056
EMBL-CDS: AAX71459.1
RefSeq_NT: NC_007296.1
EnsemblGenome: EBSTRG00000032100.
EnsemblGenome_TRS: EBSTRT00000032100
EnsemblGenome_PRO: EBSTRP00000030932
GenomeReviews: CP000056_GR
KEGG: spb:M28_Spy0345
HOGENOM: HBG698126
OMA: SNSENSK
ProtClustDB: CLSK698258
BioCyc: SPYO319701:M28_SPY0345-MONOMER
Taxonomy ID 319701
Gene Starting Position 364256
Gene Ending Position 364954
Gene Strand (Orientation) -
Protein Name exotoxin type J precursor
DNA Sequence 
>gi|71902667:364256-364954 Streptococcus pyogenes MGAS6180 chromosome, complete genome
CTTATTTAGTCCAAAGATAAATATCAAAATGGCTGAAATCTTTCATATTTATAGTCTTATTGTCTTTATA
TTTTTTAAAAATATCACTCCTTGTACTAGATGAGGTTGCATCGTATAAGTTAAAACTTTCATGTTTATTG
CCATTGATCGCAATTTCTAATTGCCCTTTTATGTATGGAGAATTAGGATCATAAATTTTGTATGTTTGCA
TAAGATATTGTCTGATTTTGAAGTCAAATTCTTGAATCGTAAAAATACGTTTATCTATTTTTATGGGATT
TATTAGTGTTTTTTGCTGGACTCCATCTATTAGTAAATTACCTACAATTTTACTATTTTCCGAATTACTG
TTTACTGATGGTGTAACCCCACCATATATATAATAAACATCATAACGAGTAAATATGTACGGAAGACCAA
AAATATTTACTTTTTGATTTTTCGTAAACTTTGTTGTAATATAGCTCTCGACCTCAGAATCAACTGAAAA
ATTTTTCTTTTTATAACTGGAAACATCAATATAAAAATCATGAGTGGTCAAGTAATCAATATTACAATTC
GTATAATCTACTGGTCTGATTTCGTATGCGTAATTTAATTGTAGCTTAACGTCTTTAATCTTTTCACTAT
CTGATTTTACACTTCCGTACCCATGAAAGATTATTATAACTAAAATTATTGTTTTTATTAATCTTTTCA
Protein Sequence 
>gi|71903011|ref|YP_279814.1| exotoxin type J precursor [Streptococcus pyogenes MGAS6180] MKRLIKTIILVIIIFHGYGSVKSDSEKIKDVKLQLNYAYEIRPVDYTNCNIDYLTTHDFYIDVSSYKKKNFSVDSEVESYITTKFTKNQKVNIFGLPYIFTRYDVYYIYGGVTPSVNSNSENSKIVGNLLIDGVQQKTLINPIKIDKRIFTIQEFDFKIRQYLMQTYKIYDPNSPYIKGQLEIAINGNKHESFNLYDATSSSTRSDIFKKYKDNKTINMKDFSHFDIYLWTK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001).
References
McCormick et al., 2001: McCormick JK, Pragman AA, Stolpa JC, Leung DY, Schlievert PM. Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen. Infection and immunity. 2001; 69(3); 1381-1388. [PubMed: 11179302].