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dltA from Streptococcus pyogenes MGAS5005

Victor ID 4362
Gene Name dltA from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571853
NCBI Protein GI 71910886
Locus Tag M5005_Spy_1073
Protein Accession YP_282436.1
Other Database IDs UniProtKB-ID: DLTA_STRP1
UniRef100: UniRef100_Q1JLB7
UniRef90: UniRef90_Q1JLB7
UniRef50: UniRef50_Q04HZ7
UniParc: UPI000003EA7D
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34156.1
EMBL-CDS: AAZ51691.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
PDB: 3LGX
EnsemblGenome: EBSTRG00000000039
EnsemblGenome_TRS: EBSTRT00000000039
EnsemblGenome_PRO: EBSTRP00000000039
EnsemblGenome: EBSTRG00000027441
EnsemblGenome_TRS: EBSTRT00000027441
EnsemblGenome_PRO: EBSTRP00000026459
GenomeReviews: AE004092_GR
Gen
Taxonomy ID 293653
Gene Starting Position 1045613
Gene Ending Position 1047151
Gene Strand (Orientation) -
Protein Name D-alanine--poly(phosphoribitol) ligase subunit 1
DNA Sequence 
>gi|71909814:1045613-1047151 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ATCATCGGTTATTGACCTCATTAATCAAAGTTTTAATATCTATCTTACCATTTGGAGTTAATGGTAGACT
ATCTCGATAAAGAAACTTAGAAGGCATCATATAACTCATCATATGATCCTTAACAGAGGCTTTGATAGCT
TTGGTTAACTCCAATTCCCTATCAAAACGCTCTTTAACCCCATCTTTGACAACGATATAGGCCAAGAGAT
TTTGAACCTTATGTTCTTTATTGTACCTTGGAACAGCCACAGCCGATGCTACCATTGGTGATTGATTCAA
CTGTTGGGAAACATCTTCTAGTTCAATACGATAACCAGCATATTTAATCTGAAAATCCAAACGCCCACCA
TACAACAAAATATTATCTTCTGTCAGTGAGCCAATGTCCCCTGTATGATAAGCAGGCTGTCCTTTAAAAG
TAAAGAAAGCTTCTGCGGTTTTCTCAGGATTGTTGAGGTAACCTTTTGACACAGCAGGCCCTGTAACAAT
AATTTCACCCTGCTCCCCTGAAGATAACTCCTTACCATCTTCATCAATAATATAGGTCGGAGAATCTGGT
TTGGGGTAGCCAATCGGCAAGCGGGTATAATTATCCACCATTTCTCTGGTAATTTCAATAGCGGATAAGG
CTACAGTCGCTTCTGTTGGTCCATAGGCATTGATAATCTTGGCACTCGGGAAACGTTCAAAGAGTTTTCG
AGCCGTAGAAACGGTTAATTCTTCGCCATCAAAATAAAAATGCGTTAAAGCTGGCATCTTAGCCTGGCAA
AAATCATCGCTAAGCATGGCCATATCAGCAAATGAAGGAGTCGATGTCCAAATGCCAACTGGAAGTTGCG
CAATCGTTGTAAATAACTGTTTAAAGTCTGCCACCAATTCTTTTGGAAGTGCAAATAAGGTTCCACCTAA
AGCCAAGGTAGGTGCCCAGTACATGACAGAAAGGTCAAAGGAATAGGGTGGCTGCGCCAGCATTTGTGGC
TGTTTAGGTACATCAAATGCTGCATCTTCGATCATCCAGTTGGTAAAGCTCAAAAGATTGTCATGTGAAA
TTTGCACCCCTTTTGGTTGGCCCGTTGTTCCAGAGGTGAAAATAATGTAATAATTATCATCTCCTTTAAC
AGAATGTGTTCGCTCATAGGGCATTTCTGCTAATTTTGCTGACTCAATCTCTGATAGTGAGACAAGGGAA
ATCCCTTCAATAGTAAGAGGGAATTCCTCAATAGCAATGATTAAACTGGGCTTTGCAATCTCAATAATCG
CTAAAATACGTTCTGGTGCTGAATGCACATCTACTGGGATATAGGCATGACCAGATTTGGTTAAAGCTAC
AAAAGTAGCTAACATATTATAAGTTTGCGCCCCAAAAACCAAAACTGGAGATTTTGCCAGTAAAGCTAAG
CTATCTATAAATGCAGCAATGCTATCAGAATCTCTTTTGAGTTGTCCGTAAGTGCGGCGTTCCCCTAAAC
AATCATAAACTGGAAAATCAGCCTGTGTCTGAGCAAACTGCTCAATACTGTCAATCATATCCTTAATCA
Protein Sequence 
>gi|71910886|ref|YP_282436.1| D-alanine--poly(phosphoribitol) ligase subunit 1 [Streptococcus pyogenes MGAS5005] MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYNMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGIWTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells (Kristian et al., 2005).
COG COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Kristian et al., 2005: Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V. D-alanylation of teichoic acids promotes group a streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion. Journal of bacteriology. 2005; 187(19); 6719-6725. [PubMed: 16166534].