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lsp from Streptococcus pyogenes M1 GAS

Victor ID 4275
Gene Name lsp from Streptococcus pyogenes M1 GAS
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 900995
NCBI Protein GI 15674864
Locus Tag SPy_0826
Protein Accession NP_269038.1
Other Database IDs UniProtKB-ID: LSPA_STRP1
UniRef100: UniRef100_Q9A0D2
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI00000C7D09
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK33759.1
EMBL-CDS: AAZ51255.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000635
EnsemblGenome_TRS: EBSTRT00000000635
EnsemblGenome_PRO: EBSTRP00000000635
EnsemblGenome: EBSTRG00000028306
EnsemblGenome_TRS: EBSTRT00000028306
EnsemblGenome_PRO: EBSTRP00000027324
GenomeReviews: AE004092_GR
GenomeReviews
Taxonomy ID 160490
Gene Starting Position 678622
Gene Ending Position 679080
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|15674250:678622-679080 Streptococcus pyogenes M1 GAS chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGATTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
ATTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|15674864|ref|NP_269038.1| lipoprotein signal peptidase [Streptococcus pyogenes M1 GAS] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].