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scpA from Streptococcus pyogenes M1 GAS

Victor ID 4277
Gene Name scpA from Streptococcus pyogenes M1 GAS
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901674
NCBI Protein GI 15675796
Locus Tag SPy_2010
Protein Accession NP_269970.1
Other Database IDs UniProtKB-ID: C5AP_STRP1
UniRef100: UniRef100_P58099
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00001355FE
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34691.1
EMBL-CDS: AAZ52333.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000102
EnsemblGenome_TRS: EBSTRT00000000102
EnsemblGenome_PRO: EBSTRP00000000102
EnsemblGenome: EBSTRG00000028547
EnsemblGenome_TRS: EBSTRT00000028547
EnsemblGenome_PRO: EBSTRP00000027565
GenomeReviews: AE004092_GR
GenomeReviews
Taxonomy ID 160490
Gene Starting Position 1676908
Gene Ending Position 1680453
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|15674250:1676908-1680453 Streptococcus pyogenes M1 GAS chromosome, complete genome
ACTAATCTTCAGTGCGTTTTGTTTTAAAGATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAA
CTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTTTTGTTGATGCTTTT
GTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAGGAGTTTTAC
CTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTGACCTGAACC
GTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGTTTGACCTGAACCGTCTTGTTCTGGTTTAGTT
TCTGGTTTTTTATCTGGTGCTTGACCTGAACCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTG
CTTGATCTGAACCGTCTTGTTCTGGTTTATTAGAGTGGCCTTCCAATAGCTTAGTCACTGGTGTATAAGT
GATGTTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCC
ATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCA
GATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAACCGGTTGGCTGGTTTTTGGTTTAGATGC
AAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACA
ATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGAACACGATAGGTGT
ATGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGA
ACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACA
ACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATT
GGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTG
GATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAA
GATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCTTTAATAATCGTCCATGGATTAGACTCTG
TAGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGC
ATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGAC
AGATTGCCAAAATCACCTCGGAAACCAATATAGGGAATACTCATAAGCTCTTCTTTTGTAGGATCTTGTT
TGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTGGGGCAAGCAAGTCCTTGCTAAATTGACT
AACATCGATTGGAATGGTGACTTGTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCA
TACAATGCTTTAGGAGCCAAGGCAAAGAGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAAT
ACAACTCTTGAGGTTTATCAGATTTGTTGTGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTT
CAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCA
TCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTG
CTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTC
ATATTGCTTTTGCAACAGTCCCATGATACCCGCTACTAATGGCGCAGACATACTAGTTCCAGAAAGTTTG
GCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGC
CGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGG
TGTCGCATTGAAGGTGATGGTTTTTTGGGGATTCTCTTTTAATAAGAGACCATCTTTTCGACTGATAAAG
GCCGCAGGCATCTGATCAACATTTGGCAATTCAATCGGGAAGCCCTTGTCCTGATTGTCATAGATCAAGA
CTCCTACAGCACCAGCTTTTTTAGCGTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAG
GGCAATCTTACCTTTGACATCCTTAAAATCATCCTCTTTCATCCCACGATTAGCATAAGCATAGTCGTAA
GCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATTTCTTTATCTTGCTGATCGGCTGTTTTGA
CCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGC
AGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGGTAGACGGGTCTTGCCCCCAAAGCTACTA
TCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTGGCATAGTCAAAGGCTTTTTTGGTTTCGT
CTGGAAGGTTGGCATAGGCTAGTGCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGAC
AGCATCTATGATAGCTTGAGCGTAGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATC
AAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTC
CTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTACTATAGTC
GTGGTAATAAGCAACCTTATCATTGACCCACTCGCCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCA
AGATCTTCTTTTGATTGGTAACGTGCTTTGGTTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAA
AACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCTTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTG
AGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCT
TGAGGGGCTAGATCATTAGCGTCATCTGCTATTGTTTCTTCTGCGTCATCAGGAGTTTGTGGGGTTTTGG
TTTCCTTTGATGATGGTGCTTCCTCAGAAACCGCTGTTGGTTGTGGGGTTTCTACAGCTTGTTCGGTAGC
AGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATG
AGCGCAATGGCAAGTTTATCAAATGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|15675796|ref|NP_269970.1| C5A peptidase [Streptococcus pyogenes M1 GAS] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVETPQPTAVSEEAPSSKETKTPQTPDDAEETIADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIIDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKENPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKLFALAPKALYETSWQKITIPANSSKQVTIPIDVSQFSKDLLAPMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSGQAPDKKPETKPEQDGSGQTPDKKPETKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTKDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRTED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].