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emm3

Victor ID 4331
Gene Name emm3
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1010042
NCBI Protein GI 21911263
Locus Tag SpyM3_1727
Protein Accession NP_665531.1
Other Database IDs UniProtKB-ID: Q8K5P9_STRP3
UniRef100: UniRef100_Q8K5P9
UniRef90: UniRef90_Q54835
UniRef50: UniRef50_P19401
UniParc: UPI000000B112
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM80334.1
EMBL-CDS: BAC64820.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000034323.
EnsemblGenome_TRS: EBSTRT00000034323
EnsemblGenome_PRO: EBSTRP00000033062
EnsemblGenome: EBSTRG00000035988.
EnsemblGenome_TRS: EBSTRT00000035988
EnsemblGenome_PRO: EBSTRP00000034638
GenomeReviews: AE014074_GR
GenomeRev
Taxonomy ID 198466
Gene Starting Position 1746201
Gene Ending Position 1747946
Gene Strand (Orientation) -
Protein Name antiphagocytic M protein, type 3
DNA Sequence 
>gi|21909536:1746201-1747946 Streptococcus pyogenes MGAS315 chromosome, complete genome
CTTAGTTTTCTTCTTTGCGTTTTACAACTGCTGCTACTCCAGCTGTTGCCATAACAGTAAGGGCTGCCGC
TGTGAAGAATGGGTTAGCTGTTTCACCTGTTGATGGTAACTGTCTCTTAGTTTCCTTCATTGGTGCTTTG
TTTTGGTTAGGTTTTGTACCTGCTTGTGGTGCTTGACCTTTACCTGGAACAGCTTTGTTTCCTGGTTTTG
TATCAGGGATTTGTGAGTCTGATGCTTTTCCAGCTCTTAGTTTTGCAAGTTCTTCAGCTTGTTTTGCTAA
TTGTTCTTTGAGTGCTTTTGCTTCTGCTTCAAGTTTTGCTTGTAGCTCAGCTTTTTCTTTTTCTGTTAAT
TTCTTGCTTTCTTCAAGCTCTTTGTTAAGTTTTTCAAGAGCAGCTAATTTGCTGTTTGCTTCTTCTAAAG
CTTTTTCAACTTGTTTCTTAGCTTCACGTGATGCGTCCAAGTCACGGCGAAGACCTTGACGGCTTGCGTC
TGAGATTTGTTTTTCTTCTTTAACCTTATCAAGTTCAGCAGTCAAGTTTGCTAAATCTTTTTCAACTTGC
TTCTTAGCTTCACGTGATGCGTCCAAGTCACGGCGAAGACCCTTACGGCTTGCTTCTGAAATCCTGTTTT
GTTCTTCAAGTTGTTTGAGAGCAGCTTCAACTTGTGCTTTTGCTTGGCGAACTGCTTCAAGATCTCTTGC
TGTACCTTTACGACTAGCATCTAAGATTTGTTTTTGTTCTGTAACTTTTGCAAGCTCTGCTTTGAGGTTG
TTTAATTCAGCTTCCGTAGCTTTTTTAGCTTGGCGAACAGCTTCAAGGTCTCTTGCTGTACCTTTACGGC
TAGCATCTAGGATTTGTTTTTGCTCTTCTAGTTGTTTAATTTGATCATCTTTTTCTGCTAGTTTTGCTTG
ATACTCATTATGAGCATGTTGGTGACCTAATGCTGCTAGTTCAAAATCTTCCTTTGCCTCTTTTAGTTTT
GTTTCTAAATCGGCAATCTTAGCTTCTAACTTTTGTTTATCAGCGGCATTAGCTAATGCTGCTAGTTCAA
AATCTTCTTTAGCATTTTGTTTAGTAGTAGCTAATTCTTGCTCTAACTGAGAAACACGATTTTGTTTTTC
AGTTAAATCTTGCATAGTACTTTCAACTTTTTGTTTAACTGTCTCTAGCTCTTCGCTAATCTGGCCAACT
TTAGCAGTTGCTTCTGTAACTTTCTTTTCTTTTTCTTCTAGTTCTTGTTGATGTCTTTTATCTGATAAAA
CATACCCCTGTTTGGCCAAGTCAAAATCTTTATCTAAGTCCTGATATTCCTTTTCCTTTTTGTCTATTTT
TTCCTTAAGTTCTTTAACCTCCTTTTCTAAATCATCTTTTTCAAAAGCCACTTTACCTAAAACTTTTTTT
ACATCTTCTCCATTTAACTCTTGTAACAGCCTCTCAGCCCAATCATTAAGGCCTTTTAGATATTCAGCCT
TTTGTCTCAGGTCAAGTCTGCCAGCTTGTGCATTATATTGTTGGTAATTACTATTATGTTTAGTATATAA
TTGTGTAACCTGATCTAACAAGTTCTCAATTTCATTTTTTAATTTAACATGTCTAGGAAACTCTCCATTA
ACACTCCTAGCATCTGCCTTTACTGTCTGCCCTGCTACCAGTCCTGTCCCTAAAACTGTCAAAGCAACCG
CTACTGAAGCCGTTCCTGTTTTTAATTTTCTAAGCGAATAGTGTCTATTCGTGTTGTTTTTAGCCA
Protein Sequence 
>gi|21911263|ref|NP_665531.1| antiphagocytic M protein, type 3 [Streptococcus pyogenes MGAS315] MAKNNTNRHYSLRKLKTGTASVAVALTVLGTGLVAGQTVKADARSVNGEFPRHVKLKNEIENLLDQVTQLYTKHNSNYQQYNAQAGRLDLRQKAEYLKGLNDWAERLLQELNGEDVKKVLGKVAFEKDDLEKEVKELKEKIDKKEKEYQDLDKDFDLAKQGYVLSDKRHQQELEEKEKKVTEATAKVGQISEELETVKQKVESTMQDLTEKQNRVSQLEQELATTKQNAKEDFELAALANAADKQKLEAKIADLETKLKEAKEDFELAALGHQHAHNEYQAKLAEKDDQIKQLEEQKQILDASRKGTARDLEAVRQAKKATEAELNNLKAELAKVTEQKQILDASRKGTARDLEAVRQAKAQVEAALKQLEEQNRISEASRKGLRRDLDASREAKKQVEKDLANLTAELDKVKEEKQISDASRQGLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEQLAKQAEELAKLRAGKASDSQIPDTKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: emm3 mutant has reduced adherence to and internalization into HEp-2 cells compared to the wild type (Eyal et al., 2003).
COG COG1196D, under D: Cell cycle control, cell division, chromosome partitioning
References
Eyal et al., 2003: Eyal O, Jadoun J, Bitler A, Skutelski E, Sela S. Role of M3 protein in the adherence and internalization of an invasive Streptococcus pyogenes strain by epithelial cells. FEMS immunology and medical microbiology. 2003; 38(3); 205-213. [PubMed: 14522456].