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scpA from Streptococcus pyogenes MGAS8232

Victor ID 4316
Gene Name scpA from Streptococcus pyogenes MGAS8232
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS8232
NCBI Gene ID 994764
NCBI Protein GI 19746910
Locus Tag spyM18_2074
Protein Accession NP_608046.1
Other Database IDs UniProtKB-ID: C5AP_STRP8
UniRef100: UniRef100_Q8NZ80
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00000D9B31
EMBL: AE009949
EMBL-CDS: AAL98545.1
RefSeq_NT: NC_003485.1
EnsemblGenome: EBSTRG00000030645
EnsemblGenome_TRS: EBSTRT00000030645
EnsemblGenome_PRO: EBSTRP00000029567
GenomeReviews: AE009949_GR
KEGG: spm:spyM18_2074
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO186103:SPYM18_2074-MONOMER
Taxonomy ID 186103
Gene Starting Position 1735694
Gene Ending Position 1739146
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|19745201:1735694-1739146 Streptococcus pyogenes MGAS8232, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAAGATATGAGCTACTAATCCAAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGCT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGTTTG
ACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCT
GGCTTATTAGAGTGGCCCTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAA
CAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAG
AGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAA
GCAATACGCTCACGGTAAATCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTG
TTGAGAATGTTGCTGATGTTGCGACTTCAAGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTG
TTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGAACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTG
CCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCGT
TGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCACACAACATTTCCTTCTTTGTCCAAGAC
TTCAGCCACAAGGTTCTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCC
CCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGT
CTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTC
AACCCCTTCTTTGACAGCTTTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTATTT
TTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGT
AGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAA
ACCAATATATGGAATGCTCATAAGCTCTTCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAG
AAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTT
GTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGC
AAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGAT
TTGTTGTGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTAT
TATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTG
GCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTA
GCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTATCTCATATTGCTTTTGCAATAGTCCCA
TGATACCCGCTACCAATGGCGCAGACATACTTGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGA
TGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTT
GAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTT
TTTGGGGATTCTCTTTTAATAAGAGACCATCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATT
TGGCAATTCAATCGGGAAGCCCTTGTCCTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTTTTTA
GCGTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTGCCTTTGACATCCT
TAAAATCATCCTCTTTCATCCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTT
TGTTGAAAGAACAGGCATTTCTTTATCTTGCTGATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGT
TTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAAT
CAGGATGATCTGCTAGAGGTAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAAT
GCTAACACCTTTTGATTTGGCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGGAGGTTAGCGTAGGCTAGT
GCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGT
AGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCAT
CGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGT
GTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTGCTATAGTCGTGGTAATAAGCAACCTTATCAT
TGACCCACTCGCCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACG
TGCTTTAGTTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACA
ACAGTCCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAA
TAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCTTGAAGGGCTAGATCATTAGCCTT
ATCTGCTACTGTTTCTTCTGCGTTATCAGGAGTTTGTGGGGTTTTGGTTTCCTTTGATGATGGTACTTCC
TCAGAAACCGCTGTTGGTTGTGGGGTTTCTACGGCTTGTTCGGCAGCAGGAGTGTCTTCTGTCACAGTAT
TTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAA
TGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|19746910|ref|NP_608046.1| C5A peptidase [Streptococcus pyogenes MGAS8232] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPAAEQAVETPQPTAVSEEVPSSKETKTPQTPDNAEETVADKANDLALQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKENPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYEIQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTLEVATSATFSTEDRRLTLASKPKTSQPIYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASARDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].