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scpA from Streptococcus pyogenes MGAS10270

Victor ID 4391
Gene Name scpA from Streptococcus pyogenes MGAS10270
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10270
NCBI Gene ID 4063044
NCBI Protein GI 94991291
Locus Tag MGAS10270_Spy1782
Protein Accession YP_599391.1
Other Database IDs UniProtKB-ID: Q1JER2_STRPD
UniRef100: UniRef100_Q1JER2
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI0000D7535C
EMBL: CP000260
EMBL-CDS: ABF34847.1
RefSeq_NT: NC_008022.1
EnsemblGenome: EBSTRG00000039384.
EnsemblGenome_TRS: EBSTRT00000039386
EnsemblGenome_PRO: EBSTRP00000037870
GenomeReviews: CP000260_GR
KEGG: sph:MGAS10270_Spy1782
eggNOG: COG1404
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO370552:MGAS10270_SPY1782-MONOMER
Taxonomy ID 370552
Gene Starting Position 1733004
Gene Ending Position 1736549
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|94989509:1733004-1736549 Streptococcus pyogenes MGAS10270 chromosome, complete genome
ACTAATCTTCAGTGCGTTTTGTTTTAAAGATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAA
CTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTTGATGCTTTT
GTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTATGAGAAGGTTGACCTTTTTGAGGAGTTTTAC
CTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTACCTGGTGTTTGACCTGAACT
ATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTGACCTGAACCGTCTTGTTCTGGTTTAGCT
TCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTG
CTTGATCTGAACCATCTTGTTCTGGCTTATTAGAGTGGCCCTCCAATAGCTTAGTCACTGGTGTATAAGT
GATGTTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCC
ATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCA
GATCCTCATCCATATAAGTGTAAGCAATACGTTCACGGTAAACCGGTTGGCTGGTTTTTGGTTTAGATGC
AAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACA
ATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAGCTAATAGGAGTGTAGCGGACACGATAGGTGT
AGGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGA
ACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACA
ACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATT
GGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTG
GATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATTTCTGAA
GATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCTTTAATAATCGTCCATGGGTTAGACTCTG
TGGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGC
ATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGAC
AGATTGCCAAAATCACCTCGGAAACCAATATATGGAATGCTCATAAGCTCTTCTTTTTTAGGATCTTGTT
TGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATCGACT
AGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCA
TACAATGCTTTAGGAGCCAAGGCAAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAAT
ACAACTCTTGAGGTTTATTAGATTTGTTATGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTT
CAGGTGAACCTTGCTTGAGGTATTGTCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCA
TCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTG
CTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTC
ATATTGCTTTTGCAACAGTCCCATGATACCCGCTACCAATGGCGCAGACATACTAGTTCCAGAAAGTTTG
GCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGC
CGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGG
TGTCGCATTGAAGGTGATGGTTTTTTTAGAATTGTCTTTTAATAAGAGACCGTCTTTTCGACTGATAAAG
GCCGCAGGCATCTGGTCAACATTTGGCAATTCAATCGGGAAGCCCTTGTCTTGATTGTCATAGATCAAGA
CCCCTACAGCACCAGCTTTTTTAGCGTTTGCAATCTTATCTTTGAAATCAATATCACCACGTTCAATAAG
GGCAATTTTGCCTTTGATATCCTTAAAATCATCCTCTTTCATCCCACGATTAGCATAAGCATAGTCGTAA
GCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATTTCTTTATCTTGCTGATCGGCTGTTTTGA
CCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGC
AGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGGTAGACGGGGCTTGCCCCCAAAGCTACTA
TCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTGGCGTAGTCAAAAGCTTTTTTGGTTTCGT
CTGGAAGGTTGGCGTAAGCTAGTGCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGAC
AGCATCTCTGATAGCTTGAGCATAGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATC
AAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTC
CTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTACTATAGTC
GTGGTAATAAGCAACCTTATCATTGACCCACTCACCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCA
AGATCTTCTTTTGATTGGTAACGTGCTTTGGCTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAA
AACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTG
AGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCT
TGAGGGGCTGGATCATTAGCCTTATCTGCTACTGTTTCTTCTGCGTCATCAGGAGTTTGTGGGGTTTTGG
CTTCCTTTGATGATGGTGCTTCCTCAGAAACCGCTGTTGGTTGTGGGGTTTCTACGGCTTGTTCGGTAGC
AGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATG
AGCGCAATGGCAAGTTTATCAAATGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|94991291|ref|YP_599391.1| C5A peptidase precursor [Streptococcus pyogenes MGAS10270] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVETPQPTAVSEEAPSSKEAKTPQTPDDAEETVADKANDPAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKPRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDIKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNSKKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSNKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKKPETKPEKDSSGQTPGKTPQKGQPSHTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRTED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].