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SPy_0019

Victor ID 4271
Gene Name SPy_0019
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 900379
NCBI Protein GI 15674263
Locus Tag SPy_0019
Genbank Accession AE004092
Protein Accession NP_268436
Other Database IDs UniProtKB-ID: Q9A1Z8_STRP1
UniRef100: UniRef100_Q7BH59
UniRef90: UniRef90_Q1JE88
UniRef50: UniRef50_Q1J944
UniParc: UPI00000D0F93
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK33158.1
EMBL-CDS: AAZ50636.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000344.
EnsemblGenome_TRS: EBSTRT00000000344
EnsemblGenome_PRO: EBSTRP00000000344
EnsemblGenome: EBSTRG00000028610.
EnsemblGenome_TRS: EBSTRT00000028610
EnsemblGenome_PRO: EBSTRP00000027628
GenomeReviews: AE004092_GR
GenomeRev
Taxonomy ID 160490
Gene Starting Position 30545
Gene Ending Position 31741
Gene Strand (Orientation) +
Protein Name putative secreted protein
Protein pI 8.81
Protein Weight 39319.35
Protein Length 398
Protein Note Best Blastp hit = gb|AAD00288.1| (U78607) putative secreted protein [Streptococcus mutans]
DNA Sequence 
>gi|15674250:30545-31741 Streptococcus pyogenes M1 GAS chromosome, complete genome
TATGAAAAAAAGAATTTTATCAGCAGTTCTTGTAAGTGGTGTTACCCTCGGAGCAGCTACAACTGTAGGA
GCGGAGGATTTAAGTACTAAGATTGCTAAGCAAGATTCTATTATCTCAAATCTGACTACAGAGCAAAAAG
CTGCACAGAATCAAGTTTCAGCGTTACAGGCTCAAGTAAGTTCACTACAATCTGAACAAGATAAACTGAC
CGCAAGAAATACAGAACTTGAGGCGCTTTCAAAGCGATTTGAGCAAGAAATTAAGGCTCTAACAAGTCAA
ATTGTTGCTCGTAATGAAAAATTAAAAAATCAAGCTCGTAGTGCTTATAAAAACAATGAAACTTCTGGTT
ATATTAATGCACTTTTGAATTCTAAATCAATTTCTGATGTTGTAAACCGTTTAGTAGCAATTAATAGAGC
TGTCTCTGCTAACGCTAAATTGTTAGAACAACAAAAAGCTGATAAAGTTTCCCTTGAAGAAAAGCAAGCT
GCTAACCAAACAGCTATTAATACCATTGCCGCTAATATGGCAATGGCTGAAGAAAACCAAAATACATTAC
GTACTCAACAAGCTAATTTGGTAGCTGCAACTGCAAATTTAGCTCTCCAATTAGCATCTGCTACTGAAGA
TAAAGCTAATTTGGTAGCTCAAAAAGAAGCTGCAGAAAAAGCTGCTGCTGAAGCCTTAGCACAAGAACAG
GCTGCTAAAGTTAAGGCACAAGAACAGGCTGCACAACAAGCAGCATCTGTTGAAGCAGCAAAATCTGCTA
TTACTCCAGCACCACAAGCTACTCCGGCAGCGCAAAGTAGTAATGCTATTGAACCAGCTGCACTCACGGC
TCCGGCAGCTCCTTCTGCAGGACCACAAACATCATATGATTCTTCTAATACTTATCCAGTTGGACAATGC
ACATGGGGAGCTAAATCTTTAGCTCCTTGGGCAGGAAATAATTGGGGAAATGGTGGTCAATGGGCTTATA
GTGCTCAAGCAGCTGGTTATCGTACTGGTTCAACGCCGATGGTAGGTGCGATTGCCGTTTGGAACGATGG
TGGTTATGGACATGTCGCCGTTGTAGTTGAGGTTCAAAGTGCCTCAAGTATTCGTGTGATGGAGTCTAAC
TACAGTGGTAGACAGTACATTGCTGACCACCGTGGCTGGTTTAATCCAACAGGTGTTACATTTATTTATC
CACACTA
Protein Sequence 
>gi|15674263|ref|NP_268436.1| putative secreted protein [Streptococcus pyogenes M1 GAS]
MKKRILSAVLVSGVTLGAATTVGAEDLSTKIAKQDSIISNLTTEQKAAQNQVSALQAQVSSLQSEQDKLT
ARNTELEALSKRFEQEIKALTSQIVARNEKLKNQARSAYKNNETSGYINALLNSKSISDVVNRLVAINRA
VSANAKLLEQQKADKVSLEEKQAANQTAINTIAANMAMAEENQNTLRTQQANLVAATANLALQLASATED
KANLVAQKEAAEKAAAEALAQEQAAKVKAQEQAAQQAASVEAAKSAITPAPQATPAAQSSNAIEPAALTA
PAAPSAGPQTSYDSSNTYPVGQCTWGAKSLAPWAGNNWGNGGQWAYSAQAAGYRTGSTPMVGAIAVWNDG
GYGHVAVVVEVQSASSIRVMESNYSGRQYIADHRGWFNPTGVTFIYPH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SPy_0019 (cdhA) mutant has severe cell division, growth defects and is attenuated in mice (Pancholi et al., 2010).
COG COG3883S, under S: Function unknown
References
Pancholi et al., 2010: Pancholi V, Boël G, Jin H. Streptococcus pyogenes Ser/Thr kinase-regulated cell wall hydrolase is a cell division plane-recognizing and chain-forming virulence factor. The Journal of biological chemistry. 2010; 285(40); 30861-30874. [PubMed: 20643653].