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ska

Victor ID 4439
Gene Name ska
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985239
NCBI Protein GI 209560110
Locus Tag Spy49_1630
Protein Accession YP_002286582.1
Other Database IDs UniProtKB-ID: B5XIM5_STRPZ
UniRef100: UniRef100_B5XIM5
UniRef90: UniRef90_P96471
UniRef50: UniRef50_P96471
UniParc: UPI00000BD04A
EMBL: CP000829
EMBL-CDS: ACI61887.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000049119.
EnsemblGenome_TRS: EBSTRT00000049127
EnsemblGenome_PRO: EBSTRP00000059100
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_1630
HOGENOM: HBG703110
OMA: GEKPYDP
ProtClustDB: CLSK443206
Taxonomy ID 471876
Gene Starting Position 1612016
Gene Ending Position 1613338
Gene Strand (Orientation) +
Protein Name Streptokinase
DNA Sequence 
>gi|209558587:1612016-1613338 Streptococcus pyogenes NZ131 chromosome, complete genome
TATGAAAAATTACTTATCTTTTGGGATGTTTGCACTGCTGTTTGCATTAACATTTGGAACAGTCAAGCCT
GTCCAAGCTATTGCTGGGTATGAATGGCTGCTAGACCGTCCATCTGTCAACAACAGCCAATTAGTTGTTA
GCGTTGCTGGTACTGTTGAGGGGACGAATCAAGAAATTAGCCTTAAATTTTTTGAAATTGACCTAACATC
ACGACCTGCTCATGGAGGAAAGACAGAGCAAGGCTTAAGTCCAAAATCAAAACCATTTGCTACAGATAAA
GGCGCAATGTCACATAAACTTGAAAAAGCTGACTTATTAAAGGCTATTCAAGAACAATTGATCGCTAACG
TTCACAGTAACGACGGCTACTTTGAGGTCATTGATTTTGCAAGCGATGCAACCATTACTGATCGAAACGG
CAAGGTCTACTTTGCTGACAAAGATGATTCGGTAACCTTGCCGACCCAACCTGTCCAAGAATTTTTGCTA
AGTGGGCATGTGCGCGTTAAACCGTATCAACCTAAAGCCGTTCACAACTCTGCTGAACGCGTTAACGTCA
ACTATGAAGTGAGCTTTGTCTCCGAAACAGGAGATTTAGACTTTACACCGTTGTTAAGAAACCAATACCA
TTTGACCACACTGGCAGTTGGTGACTCTCTTTCATCACAAGAGTTAGCAGCAATTGCCCAATTTATCCTA
TCAAAAAAACATCCAGATTATATCATTACAAAACGTGACTCCTCAATCGTCACTCATGACAATGACATTT
TCCGTACGATTTTACCAATGGATCAAGAGTTTACTTACCATATCAAAGACCGGGAACAAGCTTATAAGGC
CAATTCTAAAACAGGTATTGAAGAAAAAACGAACAACACTGACCTTATTTCTGAGAAATATTACGTCCTT
AAAAAAGGGGAAAAGCCGTATGATCCCTTTGATCGCAGTCACTTGAAACTGTTCACCATCAATTACGTTG
ATGTCAACACCAACAAATTGCTAAAAAGCGAGCAGCTCTTAACAGCTAGCGAACGTAACTTAGACTTCAG
AGATTTATACGATCCTCGTGATAAGGCTAAACTACTCTACAACAATCTCGATGCTTTTGGTATTATGGAC
TATACCTTAACTGGAAAAGTCGAGGATAATCACGATGACACCAACCGTATCATAACCGTTTATATGGGCA
AGCGACCCGAAGGAGAGAATGCTAGCTATCATTTAGCTTATGATAAAGATCGTTATACCGAAGAAGAACG
AGAAGTTTACAGCTACCTGCGTTATACAGGGACACCTATACCTGATAACCCTAAAGACAAATA
Protein Sequence 
>gi|209560110|ref|YP_002286582.1| streptokinase [Streptococcus pyogenes NZ131] MKNYLSFGMFALLFALTFGTVKPVQAIAGYEWLLDRPSVNNSQLVVSVAGTVEGTNQEISLKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDKGAMSHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDDSVTLPTQPVQEFLLSGHVRVKPYQPKAVHNSAERVNVNYEVSFVSETGDLDFTPLLRNQYHLTTLAVGDSLSSQELAAIAQFILSKKHPDYIITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIEEKTNNTDLISEKYYVLKKGEKPYDPFDRSHLKLFTINYVDVNTNKLLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPKDK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ska mutant was attenuated in mouse acute poststreptococcal glomerulonephritis model (Nordstrand et al., 2000).
References
Nordstrand et al., 2000: Nordstrand A, McShan WM, Ferretti JJ, Holm SE, Norgren M. Allele substitution of the streptokinase gene reduces the nephritogenic capacity of group A streptococcal strain NZ131. Infection and immunity. 2000; 68(3); 1019-1025. [PubMed: 10678902].