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speB from Streptococcus pyogenes MGAS5005

Victor ID 4355
Gene Name speB from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571136
NCBI Protein GI 71911548
Locus Tag M5005_Spy_1735
Protein Accession YP_283098.1
Other Database IDs UniProtKB-ID: SPEB_STRP1
UniRef100: UniRef100_P0C0J1
UniRef90: UniRef90_P68884
UniRef50: UniRef50_P68884
UniParc: UPI0000165A40
EMBL: L26158
EMBL: AF104940
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAA26987.1
EMBL-CDS: AAD17930.1
EMBL-CDS: AAK34706.1
EMBL-CDS: AAZ52353.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
PDB: 2JTC
EnsemblGenome: EBSTRG00000001024
EnsemblGenome_TRS: EBSTRT00000001024
EnsemblGenome_PRO: EBSTRP00000001024
EnsemblGenome: EBSTRG00000028628
EnsemblGenome_TRS: EBSTRT000000286
Taxonomy ID 293653
Gene Starting Position 1696948
Gene Ending Position 1698144
Gene Strand (Orientation) -
Protein Name streptococcal pyrogenic exotoxin B
DNA Sequence 
>gi|71909814:1696948-1698144 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ACTAAGGTTTGATGCCTACAACAGCACTTTGGTAACCGTTGAAGCCGCCTGCGCCGCCACCAGTACCAAG
AGCTGAAGGGTTTAGTGCGTCAAGACGGAAGAAGCCGTCAGAGACTCCACCCCAACCCCAGTTAACATGG
TAGAAGTTACGTCCGTCAGCACCATCGATAACAAAGGCATGTCCGCCTACTTTACCGACACCTTGGTAGT
ATACTGGTTGGTTTTGAGATAATTCTTTGTCAATTTGTGCTTCCCAATCTTGTTTGCTAAAGTCGCCACG
GTTGATTTGGTGAACAGATTGGTTGTAGCCAAAGTTTTCTTTCAAGGCTCTTTGAACACGAGAGCTACCT
GCAGAACCACTAGATGGACCATAATCCATGTCTACTGAAATACCAACATCAGCCATCAATTCTGAAATCG
CCATTTTTTGAACGTTAGATTCTCTTCCGCTATAAGTAGGTAAGATGTTGTTCCAGTTGTATTGTCTAGT
AGAGATAGCTGCAAACAAGTTCTTAGGATGGTTGAAATATGGGTTATTTGAGCTTAGTGTGTAAGTGTAG
TCTTTCAACCCTTTGTTAGGGTAATTATGATATTTCATAATTTGAGCAGTTGCAGTAGCAACACATCCTG
TAGCTGCATGTTGACCTACAAAAGATTGTTCACCTGGTTTTACTTTTTCAATAACAGGTGTCAATAGGTT
GTAAGGGTTACCTTGATTGTAATGAATGCCTTTTGAATCAAGGAGAGATTTAACAACTGGTTGTTTAATC
TCAGCGGTACCAGCATAAGTAGTGTCTAATTTTTTGTTTTCTTTGATTTGTTCGACATAACTTTCCATGA
AGGAAGCAATGTTTTCTTTACCGTTAGCGTCAAATGATCCGCTGGTAGAGTATCCTAGAATTTCTGGAGA
ACGTTTATCTCCTGAAACGATAACAAATCCTCCAGTAGAAATATTGTAAACATACATATTAGAGCCAGAA
AGTTCTCCACCTAAGTTAACTTTGTCAAGCTTAATATCTTCTGCGCTTCGTGCACCTGCTTTGATAGCTG
CTGATTTTTGGATAAATGTGATAGCGCTATCTTTTGCTTCTTTTTCGTTACGAGCAAAGTTTTGATCGGC
AAATACTGGGTTAGCAAGAACAAATCCACCTAATGCTAAAAGACTTAATAATCTGACACCTAATTTCTTT
TTATTCA
Protein Sequence 
>gi|71911548|ref|YP_283098.1| exotoxin B [Streptococcus pyogenes MGAS5005] MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008).
References
Chiang-Ni and Wu, 2008: Chiang-Ni C, Wu JJ. Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. Journal of the Formosan Medical Association = Taiwan yi zhi. 2008; 107(9); 677-685. [PubMed: 18796357].