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speA

Victor ID 4317
Gene Name speA
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS8232
NCBI Gene ID 995014
NCBI Protein GI 19745506
Locus Tag spyM18_0393
Protein Accession NP_606642.1
Other Database IDs UniProtKB-ID: SPEA_STRP8
UniRef100: UniRef100_P62561
UniRef90: UniRef90_P62561
UniRef50: UniRef50_P62561
UniParc: UPI0000135DD7
EMBL: AE009949
EMBL-CDS: AAL97141.1
RefSeq_NT: NC_003485.1
PDB: 1L0Y
EnsemblGenome: EBSTRG00000030989
EnsemblGenome_TRS: EBSTRT00000030989
EnsemblGenome_PRO: EBSTRP00000029911
GenomeReviews: AE009949_GR
KEGG: spm:spyM18_0393
HOGENOM: HBG692952
OMA: QELDYKV
ProtClustDB: CLSK275961
BioCyc: SPYO186103:SPYM18_0393-MONOMER
Taxonomy ID 186103
Gene Starting Position 331556
Gene Ending Position 332311
Gene Strand (Orientation) -
Protein Name exotoxin type A precursor
DNA Sequence 
>gi|19745201:331556-332311 Streptococcus pyogenes MGAS8232, complete genome
GTTACTTGGTTGTTAGGTAGACTTCAATTTGGCTTGTGTTTGAGTCAAGCGTTTCATTATCTTTATATAT
CATAAGATATTTAGATTGAGTAAATTCTGGTTCAGGGAAAAAATCAAACCAAAAACTTTCTTTATTCTTA
GGTATGAACTTTATATATCCAGTTTCATATTTAGAAGGTCCATTAGTATATAGTTGCTTATTATCTGTAA
GATATTTTCTAACTTTATAGTCTAATTCTTGAGCAGTTACCATTTTTTTATTTGTTTCAATATCAAATGA
TAGGCTTTGGATACCATCGATTGATACTTTAACGACTATCTTTTTAGGAATTTCTAAATGATTCCCTTCA
TGATTTGTTACCCCTCCGTAGATACATGCACTCCTTTCTGCATTTTCACATAAATAACAGAGATGGTAAT
ATTCTACACCATAAATATCAACGTTTTTATCCTTAAATAAAGTTGCCATCTCTTGGTTCTTAAGTTCAGT
TTTTAATTTATCATAATTTGGCCCTGAAACATTATATATTAAATCGTGAGATAAAAGTTGATCAACAGAT
TTCACATTCTCGTGAGTAACAGGGTCACCCTCATAAAGAAAATATATATTTTGAAGGTTTTTAACTAAAC
TAGATCTGTGAAGTTGGCTTGGATCGGGGTCTTGTTGAGCAAATACCTCTTGCGAGATTGTTAGTCCAAG
AAATGTCACTAAAACAAAAAATACCATTTTCTTCAATACTTTTTTATTGTTTTCCA
Protein Sequence 
>gi|19745506|ref|NP_606642.1| exotoxin type A [Streptococcus pyogenes MGAS8232] MENNKKVLKKMVFFVLVTFLGLTISQEVFAQQDPDPSQLHRSSLVKNLQNIYFLYEGDPVTHENVKSVDQLLSHDLIYNVSGPNYDKLKTELKNQEMATLFKDKNVDIYGVEYYHLCYLCENAERSACIYGGVTNHEGNHLEIPKKIVVKVSIDGIQSLSFDIETNKKMVTAQELDYKVRKYLTDNKQLYTNGPSKYETGYIKFIPKNKESFWFDFFPEPEFTQSKYLMIYKDNETLDSNTSQIEVYLTTK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits (Lee and Schlievert, 1989).
References
Lee and Schlievert, 1989: Lee PK, Schlievert PM. Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness. Journal of clinical microbiology. 1989; 27(8); 1890-1892. [PubMed: 2504778].