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SpyM3_0386

Victor ID 4327
Gene Name SpyM3_0386
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1008700
NCBI Protein GI 21909922
Locus Tag SpyM3_0386
Genbank Accession AE014074
Protein Accession NP_664190
Other Database IDs UniProtKB-ID: Q8K8A6_STRP3
UniRef100: UniRef100_Q8K8A6
UniRef90: UniRef90_Q48UQ4
UniRef50: UniRef50_Q04KM1
UniParc: UPI00000DA9B9
EMBL: AE014074
EMBL-CDS: AAM78993.1
RefSeq_NT: NC_004070.1
EnsemblGenome: EBSTRG00000033255.
EnsemblGenome_TRS: EBSTRT00000033255
EnsemblGenome_PRO: EBSTRP00000031994
GenomeReviews: AE014074_GR
KEGG: spg:SpyM3_0386
HOGENOM: HBG698025
OMA: YKHIRES
ProtClustDB: CLSK877067
BioCyc: SPYO198466:SPYM3_0386-MONOMER
Taxonomy ID 198466
Gene Starting Position 430945
Gene Ending Position 432120
Gene Strand (Orientation) +
Protein Name putative efflux protein
Protein pI 9.48
Protein Weight 40416.98
Protein Length 391
Protein Note best non-GAS blastp hit: gb|AAK99775.1| (AE008470) ABC transporter membrane-spanning permease - macrolide efflux [Streptococcus pneumoniae R6]
DNA Sequence 
>gi|21909536:430945-432120 Streptococcus pyogenes MGAS315 chromosome, complete genome
AGTGTATAGTAAAGTTATATATCGAATTGGCGATGTTATGTTTGATTTTGCTAACAATACTTTTCTTGCT
GGGCTTAATCCAGCGTCTCTATCATTAGTTGCAGTATATCAGTCTCTAGAAAGTGTCATAGGTGTTCTAT
TTAATTTATTTGGTGGAGTCATTGCAGACAGTTTCAAGCGGAAAAAAATTATTATTACTACAAATATCTT
ATGTGGCACAGCTTGCTTAGTACTCTCGTTCCTAACAAAAGAGCAATGGTTGGTTTATGCCATTGTACTA
ACTAATGTTATCTTGGCATTTATGAGTGCTTTTTCTAGTCCATCCTATAAAGCATTTACAAAAGAAATTG
TTAAAAAAGATGGTATATCACAACTTAATTCATTGCTAGAGACAACAAGTACTGTAATCAAAGTAACAGT
TCCTATGGTAGCAATTTTCTTATATAAGCTACTTGGTATACACGGTGTATTACTATTGGATGGACTATCA
TTTCTAATAGCTGCTTTACTAATTTCCTTTATTTTACCTGTTAATGACGAAGTGGTGATAAAGGAGAAGG
TGACAATCAGAGAAATATTTAACGATTTAAAAATAGGATTTAAATATGTTTACAGCCATAAGTCCATCTT
TATTATTACCGTTCTTTCTGCACTTGTTAATTTTTTTCTAGCCGCTTATAATTTATTATTGCCCTATAGT
AATCAAATGTTTGGAGAAATTTCAACTGGACTTTATGGCACTTTTTTAACAGCAGAAGCAATTGGTGGAT
TTATTGGGGCAATATTAAGTGGTTTTGTGAATAAAGAATTATCAAGTATGAGATTGATATTGTTTCTATC
TTTATCAGGACTGATGTTAATGTTAGCTCCCCCATTTTATATTATGTTTCATAATGCAATTATTTTAGCT
TTGTCACCAGCTTTATTCAGTTTATTTCTTTCCATCTTTAATATTCAATTTTTTTCTCTTGTCCAGAAAG
ATGTTGATAACGATTTTTTAGGGAGAGTGTTTGGTATTATCTTTACAATAACTATTCTTTTTATGCCTAT
TGGGACTGGCTTTTTCTCGGTGGCATTAAATCCTAACAATAGCTTTAATCTTTTTATTATTGGTTCATGC
ATTACTATATTGTCATTAGTATTTAGAATATTATTTAAAAAGTATAATATTCGTTA
Protein Sequence 
>gi|21909922|ref|NP_664190.1| putative efflux protein [Streptococcus pyogenes MGAS315]
MYSKVIYRIGDVMFDFANNTFLAGLNPASLSLVAVYQSLESVIGVLFNLFGGVIADSFKRKKIIITTNIL
CGTACLVLSFLTKEQWLVYAIVLTNVILAFMSAFSSPSYKAFTKEIVKKDGISQLNSLLETTSTVIKVTV
PMVAIFLYKLLGIHGVLLLDGLSFLIAALLISFILPVNDEVVIKEKVTIREIFNDLKIGFKYVYSHKSIF
IITVLSALVNFFLAAYNLLLPYSNQMFGEISTGLYGTFLTAEAIGGFIGAILSGFVNKELSSMRLILFLS
LSGLMLMLAPPFYIMFHNAIILALSPALFSLFLSIFNIQFFSLVQKDVDNDFLGRVFGIIFTITILFMPI
GTGFFSVALNPNNSFNLFIIGSCITILSLVFRILFKKYNIR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SpyM3_0386 mutant is attenuated in zebrafish (Kizy and Neely, 2009).
References
Kizy and Neely, 2009: Kizy AE, Neely MN. First Streptococcus pyogenes signature-tagged mutagenesis screen identifies novel virulence determinants. Infection and immunity. 2009; 77(5); 1854-1865. [PubMed: 19223485].