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hasA

Victor ID 4335
Gene Name hasA
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1010166
NCBI Protein GI 21911387
Locus Tag SpyM3_1851
Protein Accession NP_665655.1
Other Database IDs UniProtKB-ID: HASA_STRP3
UniRef100: UniRef100_Q8K5G6
UniRef90: UniRef90_P0C0H1
UniRef50: UniRef50_Q8NKX1
UniParc: UPI00000DAAED
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM80458.1
EMBL-CDS: BAC64942.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000033457
EnsemblGenome_TRS: EBSTRT00000033457
EnsemblGenome_PRO: EBSTRP00000032196
EnsemblGenome: EBSTRG00000035255
EnsemblGenome_TRS: EBSTRT00000035255
EnsemblGenome_PRO: EBSTRP00000033905
GenomeReviews: AE014074_GR
GenomeReviews
Taxonomy ID 198466
Gene Starting Position 1880497
Gene Ending Position 1881756
Gene Strand (Orientation) +
Protein Name hyaluronan synthase
DNA Sequence 
>gi|21909536:1880497-1881756 Streptococcus pyogenes MGAS315 chromosome, complete genome
TGTGCCTATTTTTAAAAAAACTTTAATTGTTTTATCCTTTATTTGTTTGATATCTATCTTGATTTATCTA
AATATGTATCTATTTGGAACATCAACTGTAGGAATTTATGGAGTAATATTAATAACCTATCTAGTTATTA
AACTTGGATTATCTTTCCTTTATGAGCCATTTAAAGGAAATCCACATGACTATAAAGTTGCTGCTGTAAT
TCCTTCTTATAATGAAGATGCCGAGTCATTATTAGAAACACTTAAAAGTGTGTTAGCACAGACCTATCCG
TTATCAGAAATTTATATTGTTGATGATGGGAGTTCAAACACAGATGCAATACAATTAATTGAAGAGTATG
TAAATAGAGAAGTGGATATTTGTCGAAACGTTATCGTTCACCGTTCCCTTGTCAATAAAGGAAAACGCCA
TGCTCAAGCGTGGGCATTTGAAAGATCTGACGCTGACGTTTTTTTAACCGTAGATTCAGATACTTATATC
TATCCAAATGCCTTAGAAGAACTCCTAAAAAGCTTCAATGATGAGACAGTTTATGCTGCAACAGGACATT
TGAATGCTAGAAACAGACAAACTAATCTATTAACGCGACTTACAGATATCCGTTACGATAATGCCTTTGG
GGTGGAGCGTGCTGCTCAATCATTAACAGGTAATATTTTAGTTTGCTCAGGACCATTGAGTATTTATCGA
CGTGAAGTGATTATTCCTAACTTAGAGCGCTATAAAAATCAAACATTCCTAGGTTTACCTGTTAGCATTG
GGGATGATCGATGTTTAACAAATTATGCTATTGATTTAGGACGCACTGTCTACCAATCAACAGCTAGATG
TGATACTGATGTACCTTTCCAATTAAAAAGTTATTTAAAGCAACAAAATCGATGGAATAAATCTTTTTTT
AGAGAATCTATTATTTCTGTCAAAAAAATTCTTTCTAATCCCATCGTTGCCTTATGGACTATTTTCGAAG
TCGTTATGTTTATGATGTTGATTGTCGCAATTGGGAATCTTTTGTTTAATCAAGCTATTCAATTAGACCT
TATTAAACTTTTTGCCTTTTTATCCATCATCTTTATCGTTGCTTTATGTCGTAATGTTCATTATATGGTC
AAACATCCTGCTAGTTTTTTGTTATCTCCTCTGTATGGAATATTACACTTGTTTGTCTTACAGCCCCTAA
AACTTTATTCTTTATGCACCATTAAAAATACGGAATGGGGAACACGTAAAAAGGTCACTATTTTTAAATA
Protein Sequence 
>gi|21911387|ref|NP_665655.1| hyaluronan synthase [Streptococcus pyogenes MGAS315] MPIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGNPHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNLERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hasA mutant is attenuated in zebrafish (Kizy and Neely, 2009).
COG COG1215M, under M: Cell wall/membrane/envelope biogenesis
References
Kizy and Neely, 2009: Kizy AE, Neely MN. First Streptococcus pyogenes signature-tagged mutagenesis screen identifies novel virulence determinants. Infection and immunity. 2009; 77(5); 1854-1865. [PubMed: 19223485].