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nga

Victor ID 4272
Gene Name nga
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 900488
NCBI Protein GI 15674370
Locus Tag SPy_0165
Protein Accession NP_268544.1
Other Database IDs UniProtKB-ID: Q7DAN2_STRP1
UniRef100: UniRef100_Q9R304
UniRef90: UniRef90_Q1JDW0
UniRef50: UniRef50_Q1J8R6
UniParc: UPI00000D451E
EMBL: AE004092
EMBL-CDS: AAK33265.1
RefSeq_NT: NC_002737.1
EnsemblGenome: EBSTRG00000001529.
EnsemblGenome_TRS: EBSTRT00000001529
EnsemblGenome_PRO: EBSTRP00000001529
GenomeReviews: AE004092_GR
KEGG: spy:SPy_0165
HOGENOM: HBG697946
ProtClustDB: CLSK698238
BioCyc: SPYO160490:SPY0165-MONOMER
Taxonomy ID 160490
Gene Starting Position 149586
Gene Ending Position 150929
Gene Strand (Orientation) +
Protein Name NAD glycohydrolase
DNA Sequence 
>gi|15674250:149586-150929 Streptococcus pyogenes M1 GAS chromosome, complete genome
CATGAGAAACAAAAAAGTAACATTAGCTCATATTGTCGCAAAGACAAGTGTTGCTATTGCTTTGGCTGGA
GCAATGGGTAGCAGTTTATTAGCTAATAGCACAACGTACGCTGTTAGTGGCAAAGAAAATAAAAAAAGCG
ATGTCAAATATGAAACGACCAAAGTTATGGAAGCTAACGCAACTTCCTCTAAAGAAGACAATCATGTCAT
GCACACATTAGACGGCTCAATGAGTACTGTCTGGGAGGAAAATTCACCTGGTGGTGGTGTTGGTGAAGTA
CTTTCCTACAAGTTTGCGTCCCCGATGCATATTGGGAGAATTTTAATTGTTAATGGAGATACATCTAGCA
AGGAGAATTACTACAAGAAAAATAGAATTGCAAAGGCTGATGTTAAATACTATAACAGGAATAAATTGGT
CCTCTTTCAAAAAATTGAATTAGGCGACACCTACACTAAAAAACCGCATCACATTGAGATTGATAAAAAA
TTAGATGTTGATCGTATTGATATTGAGGTAACAGAGGTCCATCAGGGACAAAACAAGGATATTTTAGCCT
TGTCAGAGGTCACTTTTGGCAATATAGAACGCGATATTTTTGAAAAAAAGTTTAAAGAAATTAAAGATAA
ATGGGTAACAGATAAACAAGCAGATGAGTTTATTGAAACTGCCGACAAGTATGCTGATAAAGCTGTTCAG
ATGTCTGCTGTTGCGTCACGTGCTGAGTATTATCGGATGTACGTTAGCCGCAAATACCACTACAAAAAAG
AGTTTGTTGAAAAACTAAAACAAGTCTACAAAGAAAGCGGAGCTTCCCACGTTACAAGCAAAAAAGATGT
GATGTTAGCTTTTGACGATGCTAAAAAAAAGTCAACGATTGGTCGACAAGAAAACGGTCTTTTTGTGACA
AGTTTTGCTGAGGATATGGCTTTGCTCTTTACTGATCAAGGTAAGTTAAAATCAGCTGACCAAATTGAAA
ATATAAAAGATGTCGATAGCGGAAAATATAGCGATGGGGTTTATCAATATGAGTACGATTCTGAACTAAC
AAAAAACATTGATAAGCTAGGCTATATCCGAACAGCTAGCGGAGATACTCCTGGAGCAAATTCGCTCAAC
GTTCCTGGTTGCCAAACGTGGTCAGGAAAACACATTGAAAATTCAGAAAGTGAATTAATTTTCCCATCGA
TTAGTGTTAAAGATCTAAAATCTAAAGCTGTCTTAGCAGAGATTGATGCCAAAGGCTATTTTGAAATTAT
TGATCCTACCATCATTGCTCCAAATGGTGACCATAAAAAAGTAACTGGTCGCTTCAAAATTAAGAAAATG
CAAGATAGGAAGTA
Protein Sequence 
>gi|15674370|ref|NP_268544.1| NAD glycohydrolase [Streptococcus pyogenes M1 GAS] MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENKKSDVKYETTKVMEANATSSKEDNHVMHTLDGSMSTVWEENSPGGGVGEVLSYKFASPMHIGRILIVNGDTSSKENYYKKNRIAKADVKYYNRNKLVLFQKIELGDTYTKKPHHIEIDKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNIERDIFEKKFKEIKDKWVTDKQADEFIETADKYADKAVQMSAVASRAEYYRMYVSRKYHYKKEFVEKLKQVYKESGASHVTSKKDVMLAFDDAKKKSTIGRQENGLFVTSFAEDMALLFTDQGKLKSADQIENIKDVDSGKYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNVPGCQTWSGKHIENSESELIFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDHKKVTGRFKIKKMQDRK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nga mutant is attenuated in mice (Tatsuno et al., 2010).
References
Tatsuno et al., 2010: Tatsuno I, Isaka M, Minami M, Hasegawa T. NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates. BMC microbiology. 2010; 10; 144. [PubMed: 20470439].