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speJ from Streptococcus pyogenes M1 GAS

Victor ID 4273
Gene Name speJ from Streptococcus pyogenes M1 GAS
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 900684
Uniprot ID Q99QN1
NCBI Protein GI 15674561
Locus Tag SPy_0436
Protein Accession NP_268735.1
Other Database IDs UniProtKB-ID: Q99QN1_STRP1
UniRef100: UniRef100_Q7BAE3
UniRef90: UniRef90_Q7BAE3
UniRef50: UniRef50_Q7BAE3
UniParc: UPI00000D5E37
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK33456.1
EMBL-CDS: AAZ50974.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000082.
EnsemblGenome_TRS: EBSTRT00000000082
EnsemblGenome_PRO: EBSTRP00000000082
EnsemblGenome: EBSTRG00000028920.
EnsemblGenome_TRS: EBSTRT00000028920
EnsemblGenome_PRO: EBSTRP00000027938
GenomeReviews: AE004092_GR
GenomeRev
Taxonomy ID 160490
Gene Starting Position 361431
Gene Ending Position 362129
Gene Strand (Orientation) -
Protein Name putative exotoxin (superantigen)
DNA Sequence 
>gi|15674250:361431-362129 Streptococcus pyogenes M1 GAS chromosome, complete genome
CTTATTTAGTCCAAAGGTAAATATCAAAATGGCTGAAATCTTTCATATTTATAGTCTTATTGTCTTTATA
TTTTTTAAAAATATCACTCCTTGTACTAGATGAGGTTGCATCATATAAGTTAAAACTTTCATGTTTATTG
CCATTGATCGCAATTTCTAATTGCCCTTTTATGTATGGAGAATTAGGATCATAAATTTTGTATGTTTGCA
TAAGATATTGTCTGATTTTGAAGTCAAATTCTTGAATCGTAAAAATAGGTTTATCTATTTTTATGGGATT
TATTAGTGTTTTTTGCTGGACTCCATCTATTAGTAAATTACCTACAATTTTACTATTTTCCGAATTACTG
TTTACTGATGGTGTAACCCCACCATATATATAATAAACATCATAACGAGTAAATATGTACGGAAGACCAA
AAATATTTACTTTTTGATTTTTCGTAAACTTTGTTGTAATATAGCTCTCGACCTCAGAATCAACTGAAAA
ATTTTTCTTTTTATAACTGGAAATATCAATATAAAAATCATGAGTAGTCAAGTAATCAATATTACAATTC
GTATAATCTACTGGTATGATTTCGTATGCGTAATTTAATTGTAGCTTAACGTCTTTAATATTTTCACTAT
CTGATTTTACACTTCCGTACCCATGAAAGATTATTATAACTAAAATTATTGTTTTTATTATTCTTTTCA
Protein Sequence 
>gi|15674561|ref|NP_268735.1| exotoxin [Streptococcus pyogenes M1 GAS] MKRIIKTIILVIIIFHGYGSVKSDSENIKDVKLQLNYAYEIIPVDYTNCNIDYLTTHDFYIDISSYKKKNFSVDSEVESYITTKFTKNQKVNIFGLPYIFTRYDVYYIYGGVTPSVNSNSENSKIVGNLLIDGVQQKTLINPIKIDKPIFTIQEFDFKIRQYLMQTYKIYDPNSPYIKGQLEIAINGNKHESFNLYDATSSSTRSDIFKKYKDNKTINMKDFSHFDIYLWTK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001).
Predicted Interacting Host Protein A2AAZ0; A2ADX3; A2BEU2; A2BEY5; A2BF36; A6NFU0; A6NGN9; A6NJ16; A6NJ33; A6NJS3; A6NJW9; A6NLU5; A6NMB1; A8K3U1; A8K4G0; A8MQ45; A8MTB9; A8MVW5; A8MVZ5; A8MX21;
A8MXK1; B0S7V1; B0S7Y6; B0S7Y8; B0UYV8; B0UYV9; B0UZ92; B0V056; B0V1E4; B0V1U9; B0V1V1; B3KTR6; B4DKN2; B4DPU4; B4DPY3; B4DQ71; B4DT80; B4DW77; B4E2I8; B5MCE1;
B5MCX6; B7Z5W1; B8ZZZ4; C9IY66; C9IZX3; C9J0B0; C9J3Q8; C9J795; C9J7D0; C9J877; C9J8J7; C9J8P3; C9J8Z4; C9JBA5; C9JD07; C9JDD2; C9JGG1; C9JJ79; C9JMW0; C9JMW3;
C9JN07; C9JNC3; C9JNZ3; C9JQT8; C9JT30; C9JTE0; C9JUV8; C9JVU4; C9JWP2; C9JXS1; C9JY13; C9JY48; C9JZT5; C9JZW6; D0FY33; D3YHP0; D6RAK7; D6RBS1; D6RBX9; D6RC59;
D6RFI7; D6RG04; D6RGZ6; E5RHN3; E5RIF6; E7ENH0; E7ENV9; E7ENX8; E7EQY3; E7EUB1; E7EW65; E7EWP3; E7EX79; E7EX88; E9PC55; E9PD01; E9PF17; E9PFX0; E9PI25; E9PIB1;
E9PJA1; E9PJE9; E9PJJ4; E9PJP6; E9PKK2; E9PL79; E9PMV2; E9PNS8; E9PR26; E9PRP3; E9PRR1; E9PRX1; F2Z2Y9; F5GZ59; F5H125; F5H135; F5H204; F5H556; F5H724; F6S093;
F6UB75; F8VQJ4; F8W1U8; F8W1V0; F8W8C9; F8W8J5; F8WBA1; F8WDW9; G3XAA7; G5E978; G5E9F7; H0Y2W6; H0Y4X4; H0Y5P2; H0Y732; H0Y7G7; H0Y7Y7; H0Y8A0; H0YDP1; H0YG94;
H0YK40; H0YK59; H0YLT8; H0YM81; H0YN85; H3BML4; H3BRP9; H3BRY4; H3BT26; H3BTH8; H3BUA5; H3BV43; H7BYC3; H7C1I4; H7C1X1; H7C4F8; H7C4L0; H7C523; H9KV29; H9KVA7;
J3KPN5; J3KQ99; J3KR39; J3KS52; J3QL19; J3QLM0; J3QQW1; J3QRQ4; K4DIA0; K7EJW1; K7EKM5; K7EL06; M0QX61; M0QX68; M0QX98; M0QXP2; M0QXR5; M0QXV9; M0QXW0; M0QY31;
M0QY44; M0QY65; M0QYF3; M0QYU2; M0QZQ1; M0R0E4; M0R0U8; M0R109; M0R1G9; M0R235; M0R276; M0R2K4; M0R2P9; M0R363; O00241; O00478; O00481; O14594; O14931; O15389;
O43699; O60487; O60500; O60939; O75054; O75144; O75871; O95297; O95727; O95944; O95976; P01593; P01594; P01595; P01596; P01597; P01598; P01599; P01600; P01601;
P01602; P01603; P01604; P01605; P01606; P01607; P01608; P01609; P01610; P01611; P01612; P01613; P01614; P01615; P01616; P01617; P01619; P01620; P01621; P01622;
P01623; P01624; P01625; P01699; P01700; P01701; P01702; P01703; P01704; P01705; P01706; P01707; P01708; P01709; P01710; P01711; P01712; P01713; P01714; P01715;
P01716; P01717; P01718; P01719; P01720; P01721; P01722; P01730; P01732; P01733; P01737; P01742; P01743; P01744; P01760; P01761; P01762; P01763; P01764; P01765;
P01766; P01767; P01768; P01769; P01770; P01771; P01772; P01773; P01774; P01775; P01776; P01777; P01778; P01779; P01780; P01781; P01782; P01814; P01815; P01816;
P01817; P01818; P01824; P01825; P01833; P01903; P01906; P01909; P01911; P01912; P01920; P03979; P04206; P04207; P04208; P04209; P04211; P04229; P04430; P04431;
P04432; P04433; P04434; P04435; P04436; P04437; P04438; P04440; P05538; P06309; P06310; P06311; P06312; P06313; P06314; P06315; P06316; P06317; P06318; P06319;
P06326; P06331; P06340; P06729; P06731; P06887; P06888; P06889; P09326; P09564; P10915; P10966; P11464; P11465; P11912; P12018; P13611; P13688; P13760; P13761;
P13762; P13765; P15151; P16112; P16410; P18135; P18136; P20036; P20039; P20138; P23083; P25189; P28067; P28068; P30530; P31997; P33681; P35968; P40198; P40199;
P40259; P42081; P43121; P57087; P78310; P78324; P78410; P79483; P80362; P80419; P80421; P80422; P80748; P83593; Q00887; Q00888; Q00889; Q01151; Q08708; Q08ET2;
Q13046; Q13410; Q14002; Q14CZ8; Q15116; Q15223; Q15227; Q15238; Q15762; Q16557; Q16653; Q29974; Q2WEN9; Q30118; Q30134; Q30154; Q30167; Q3KPI0; Q495A1; Q496F6;
Q496M1; Q5DTA9; Q5DTB0; Q5DX21; Q5JVN7; Q5JXA8; Q5JXA9; Q5SP00; Q5SP06; Q5SP12; Q5SQ64; Q5SQ65; Q5SQ72; Q5SQ90; Q5SQ91; Q5SR05; Q5STM1; Q5SU54; Q5SUK5; Q5T2D2;
Q5T2L0; Q5T3I7; Q5T3I8; Q5T3J1; Q5TFQ5; Q5TFQ8; Q5VU13; Q5Y7A7; Q5Y7D6; Q5ZPR3; Q6PID9; Q6UWV2; Q6UX41; Q6UXE8; Q6UXG3; Q6UXG8; Q6UXN2; Q6UXZ3; Q6ZMC9; Q7KYR7;
Q7Z692; Q7Z7D3; Q86UW8; Q86W61; Q86WK6; Q86XK7; Q86YT9; Q8IW00; Q8IWT1; Q8MGR0; Q8N0Z9; Q8N126; Q8N3J6; Q8NFZ8; Q8TAG5; Q8TDQ0; Q8TDQ1; Q8WVV5; Q8WWV6; Q92692;
Q93033; Q95IE3; Q969P0; Q96AP7; Q96D42; Q96DU3; Q96GW7; Q96H15; Q96ID5; Q96IQ7; Q96KV6; Q96LC7; Q96N03; Q96NY8; Q96PL5; Q96PQ1; Q96RL6; Q96S86; Q99795; Q9BRK3;
Q9BX59; Q9BX67; Q9BY67; Q9BZZ2; Q9GIY3; Q9GZV7; Q9H106; Q9H6B4; Q9H7M9; Q9NP99; Q9NQ25; Q9NQS3; Q9NY72; Q9NYZ4; Q9NZC2; Q9NZJ1; Q9NZQ7; Q9P1W8; Q9P2B2; Q9TQE0;
Q9UEL6; Q9UGN4; Q9UIR0; Q9UKI3; Q9UKJ0; Q9UKJ1; Q9UM44; Q9UPX0; Q9UQ72; Q9UQ74; Q9Y279; Q9Y286; Q9Y336; Q9Y624; R4GND0
References
McCormick et al., 2001: McCormick JK, Pragman AA, Stolpa JC, Leung DY, Schlievert PM. Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen. Infection and immunity. 2001; 69(3); 1381-1388. [PubMed: 11179302].