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lsp from Streptococcus pyogenes MGAS6180

Victor ID 4353
Gene Name lsp from Streptococcus pyogenes MGAS6180
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS6180
NCBI Gene ID 3574788
NCBI Protein GI 71903283
Locus Tag M28_Spy0617
Protein Accession YP_280086.1
Other Database IDs UniProtKB-ID: LSPA_STRPM
UniRef100: UniRef100_Q1JCF3
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI000000AF69
EMBL: CP000056
EMBL-CDS: AAX71731.1
RefSeq_NT: NC_007296.1
EnsemblGenome: EBSTRG00000032635
EnsemblGenome_TRS: EBSTRT00000032635
EnsemblGenome_PRO: EBSTRP00000031467
GenomeReviews: CP000056_GR
KEGG: spb:M28_Spy0617
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
BioCyc: SPYO319701:M28_SPY0617-MONOMER
Taxonomy ID 319701
Gene Starting Position 637815
Gene Ending Position 638273
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|71902667:637815-638273 Streptococcus pyogenes MGAS6180 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCCGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGGTTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|71903283|ref|YP_280086.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS6180] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].