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mga from Streptococcus pyogenes M1 GAS

Victor ID 4280
Gene Name mga from Streptococcus pyogenes M1 GAS
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901678
NCBI Protein GI 15675800
Locus Tag SPy_2019
Protein Accession NP_269974.1
Other Database IDs UniProtKB-ID: Q99XU9_STRP1
UniRef100: UniRef100_Q99XU9
UniRef90: UniRef90_Q1JJR1
UniRef50: UniRef50_P19401
UniParc: UPI00000C7EF8
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34695.1
EMBL-CDS: AAZ52338.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000001503.
EnsemblGenome_TRS: EBSTRT00000001503
EnsemblGenome_PRO: EBSTRP00000001503
EnsemblGenome: EBSTRG00000027766.
EnsemblGenome_TRS: EBSTRT00000027766
EnsemblGenome_PRO: EBSTRP00000026784
GenomeReviews: AE004092_GR
GenomeRev
Taxonomy ID 160490
Gene Starting Position 1685425
Gene Ending Position 1687014
Gene Strand (Orientation) -
Protein Name M protein trans-acting positive regulator
DNA Sequence 
>gi|15674250:1685425-1687014 Streptococcus pyogenes M1 GAS chromosome, complete genome
TCTAAGTTGTGGAGGGGGGGGCATGCAACTTGTTGGGGGGAGTGGGTAAGATAACCTCTTTGCGATGAAA
GTCCAAGGGGTTGATGGGTTTGTCTAGTGGCAAGCTGTCTGCAAAGCTGATGTTTAAAAACGCATTGAGC
TTGTCAATAATCGCTTCTGGAATCATTTTGTGGAAAAAGAAAATTTCTAGCTCTTCGCTTTTTCCTACCA
TAACATCTGTCACGATCACATCATACTGTTTTTCAATCTCTTCTAGATCGATGGTCAGAGCATCTAGCTC
ATTGAAGTTTGTGATGCTAAAAAACTCTCCGACGTACTTTTTTAGGAAATTACCAACACTGTTAAAACTT
CTTTCAATCACCAGAAGACGAATTTTTTCATCTTTTTGATTTACTTTTAGGAAACTATTTTCCCAAGTGA
TGAAAAAGGCGTAGATCAATTGGTTAGTCAACTCTGTGCTGATAGGTTCTTTCTCTGAACGCATCAGTTT
TTCTACACCTGCTACAAATGCTTTATAAAGATGAGGGTGTTCTTGCTTGTAAAAGTTGAGGTAACTTTTT
TTGTAATCGAAAAATAGGTAATTAGCTGTGATATCTTCTTCTTTCAATACGGTAGTGTTATGAAGGATGA
CAGCTACTTCGTATTTGTTGGTGACGCTGAGATTGAGCCTGATTTCTAACTCATCAAGGAGATGAACCCA
GTTGGTCACTTTTCGACAGCCCGTTGGTGAGTCTTGTTTGATGCTATCAAACGCATAACCGATTTCTAAT
TGGTCATTAACGTGATTAGAGAACATCTCAGCTATGGTAGTCTCATCTAGGTATAGTCCAAATTTGAGGT
GAAACAAGCGTGAAAGGTCTTGGAATTCTAAGGATGATTGGATGAGCTGAGAAAAACGTTGACTGGTTTT
TTTGTTGTCGTAGACGGCAGAGTGTCCCTTGTAATAACGAATCAAGTTAACTGAGCTTAGTATTTTAAGG
TGCTGAAATAATGTAAAATTAACCCTCACATCGACCTCTTTTATCATTAAACTGAGTAGCCGCTCACAGT
TCTTTAAGTTTAGGATTTCCCCAAAAGGCCACTCTGAGATTTTATAGGCTTCCGAAAAATACTTGAGGTA
AAATAGTCGAATCTGGTGTTCATCTCCTGATACTTGTACGGGACTAGTTAAAATAGTAATACCAAAGGTA
TGCATCAAATAGGCATTGGTTTTTTTGATGAGACGCTTGAGTGTTGAAAGGCTCACAAAGAGCTCTTCAG
CTAATTCTTCCAAAGAGTTGAAGTCTCTGAAAAAAAGGGTCTCCAGCAATTTAAATGATTGAGAGTGTCT
CAGAGCTTTCTGATAGACTTCTTGCAAACCGCAATGTTGATGGTACCAGATTGTAATATAACCATTTTTA
TAGGTAATTCCTCCCACTTCCTTCATAAATTGCATGTTAGTGAGACATGTTTGCAATGTTAACATGGAGA
TGTTGAGAGCTTTGCTGAGTTCTTTATCTTTGACGCCAATGGCGTCAGCGTTTTCTGTTACGTATGAGAT
TAATTTTAGTTCTCTCCACTGTTGACTTGTAAACAACTTACTTACATACA
Protein Sequence 
>gi|15675800|ref|NP_269974.1| M protein trans-acting positive regulator [Streptococcus pyogenes M1 GAS] MYVSKLFTSQQWRELKLISYVTENADAIGVKDKELSKALNISMLTLQTCLTNMQFMKEVGGITYKNGYITIWYHQHCGLQEVYQKALRHSQSFKLLETLFFRDFNSLEELAEELFVSLSTLKRLIKKTNAYLMHTFGITILTSPVQVSGDEHQIRLFYLKYFSEAYKISEWPFGEILNLKNCERLLSLMIKEVDVRVNFTLFQHLKILSSVNLIRYYKGHSAVYDNKKTSQRFSQLIQSSLEFQDLSRLFHLKFGLYLDETTIAEMFSNHVNDQLEIGYAFDSIKQDSPTGCRKVTNWVHLLDELEIRLNLSVTNKYEVAVILHNTTVLKEEDITANYLFFDYKKSYLNFYKQEHPHLYKAFVAGVEKLMRSEKEPISTELTNQLIYAFFITWENSFLKVNQKDEKIRLLVIERSFNSVGNFLKKYVGEFFSITNFNELDALTIDLEEIEKQYDVIVTDVMVGKSEELEIFFFHKMIPEAIIDKLNAFLNISFADSLPLDKPINPLDFHRKEVILPTPPNKLHAPPSTT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008).
References
Luo et al., 2008: Luo F, Lizano S, Banik S, Zhang H, Bessen DE. Role of Mga in group A streptococcal infection at the skin epithelium. Microbial pathogenesis. 2008; 45(3); 217-224. [PubMed: 18588968].