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scpA from Streptococcus pyogenes str. Manfredo

Victor ID 4430
Gene Name scpA from Streptococcus pyogenes str. Manfredo
Sequence Strain (Species/Organism) Streptococcus pyogenes str. Manfredo
NCBI Gene ID 4964259
NCBI Protein GI 139474482
Locus Tag SpyM51681
Protein Accession YP_001129198.1
Other Database IDs UniProtKB-ID: A2RGL9_STRPG
UniRef100: UniRef100_A2RGL9
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI0000F0941B
EMBL: AM295007
EMBL-CDS: CAM31001.1
RefSeq_NT: NC_009332.1
EnsemblGenome: EBSTRG00000047336.
EnsemblGenome_TRS: EBSTRT00000047344
EnsemblGenome_PRO: EBSTRP00000045472
GenomeReviews: AM295007_GR
KEGG: spf:SpyM51681
eggNOG: COG1404
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
Taxonomy ID 160491
Gene Starting Position 1668993
Gene Ending Position 1672445
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|139472888:1668993-1672445 Streptococcus pyogenes str. Manfredo, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAAGATATGAGCTACTAATCCAAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGCT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGCTTG
ATCTGAACCGTCTTGTTCTGGGTTAGTTTCTGGCTTTTTGTCTGGTACTTGATCTGAACCATCTTGTTCT
GGCTTATTAGAGTGACCTTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAA
CAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAG
AGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAA
GCAATACGCTCACGGTAAACCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTG
TTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTG
TTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTG
CCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCAT
TGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGAC
TTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCC
CCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGT
CTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTC
AACCCCTTCTTTGACAGCTTTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTGTTT
TTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGT
AGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAA
ACCAATATATGGAATGCTCATAAGCTCTTCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAG
AAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTT
GTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGC
AAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGAT
TTGTTATGAACTGTTACTGTTACTTCAAATGTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTAT
TATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCAACTGCTCCTGCTCCTTGTTG
GCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTA
GCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAACAGTCCCA
TGATACCCGCTACCAATGGCGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGA
TGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTT
GAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTT
TTTGAGGATTGTCTTTTAATAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATT
TGGCAATTCAATCGGGAAGCCCTTGTCTTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTTTTTA
GCGTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATTTTGCCTTTGACATCCT
TAAAATCATCCTCTTTCGTCCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTT
TGTTGAAAGAACAGGCATTTCTTTATCTTGCTTATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGT
TTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAAT
CAGGATGATCTGCTAGAGGTAGACGGGTCTTGCCCCCAAAACTACTATCATTACCAGCTGAGGTCACAAT
GCTAACACCTTTTGATTTGGCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGGAGGTTAGCGTAGGCTAGT
GCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGT
AGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCAT
CGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGT
GTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTACTATAGTCGTGGTAATAAGCAACCTTATCAT
TGACCCACTCGCCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACG
TGCTTTAGTTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACA
ACGGTTCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAA
TAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCCTC
ATCTGCTACTGTTTCTTCTGCGTCATCAGGAGTTTGTGGGGTTTTGGTTTTCTTTGATGATGGTGCTTCC
TCAGAAACCGCTGTTGGTTGTGGGGTTTCTACGGCTTGTTCGGTAACAGGAGTGTCTTCTGTCACAGTAT
TTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATAGCAAGTTTATCAAA
TGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|139474482|ref|YP_001129198.1| C5A peptidase precursor [Streptococcus pyogenes str. Manfredo] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPVTEQAVETPQPTAVSEEAPSSKKTKTPQTPDDAEETVADEANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADKQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDTFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQVPDKKPETNPEQDGSDQAPDKKPETKPEQDGSGQTPGKTPQKGQPSRTLEKRSSKRALATKASARDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].