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scpA from Streptococcus pyogenes MGAS315

Victor ID 4330
Gene Name scpA from Streptococcus pyogenes MGAS315
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1010041
NCBI Protein GI 21911262
Locus Tag SpyM3_1726
Protein Accession NP_665530.1
Other Database IDs UniProtKB-ID: C5AP_STRP3
UniRef100: UniRef100_Q8K5Q0
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI000000B111
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM80333.1
EMBL-CDS: BAC64819.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000034577
EnsemblGenome_TRS: EBSTRT00000034577
EnsemblGenome_PRO: EBSTRP00000033316
EnsemblGenome: EBSTRG00000035361
EnsemblGenome_TRS: EBSTRT00000035361
EnsemblGenome_PRO: EBSTRP00000034011
GenomeReviews: AE014074_GR
GenomeReviews
Taxonomy ID 198466
Gene Starting Position 1742322
Gene Ending Position 1745831
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|21909536:1742322-1745831 Streptococcus pyogenes MGAS315 chromosome, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAAGATATGAGCTACTAATCCAAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTATCATTAGTCGTTGGTAACTGATCTCTTGCT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGCTTG
ACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGACCTGAACCGTCTTGTTCT
GGTTTAGTTTCTGGAGTTTTGTCTGGTACTTGATCTGAACCGTCTTGTTCTGGCTTGTTAGAGTGACCCT
CCAATAGGTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGA
CATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCA
TTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAA
CCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGCTGAGAATGTTGCCGATGT
TGCGGCTTCAGGCGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAGCTA
ATCGGAGTGTAGCGAACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGT
CCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAAC
TTGCTCGGTTACCTCACTTGTCCAAACAACATCTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTA
GCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAG
CATATGGTTTGCCATTAGCATGACGGTGGATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACC
TGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCT
TTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAACTGTA
ATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCT
ATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAAACCAATATATGGAATGCTC
ATAAGCTCTTCTTTTGTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTT
GGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTGGCTGG
AATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGCAAAGTGTTTTCCATCTACT
TTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACTGTTACTG
TTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTCACATA
CATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCT
TTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTG
ATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAATAGTCCCATGATACCCGCTACCAATGG
CGCAGACATACTAGTTCCAGAAAGTTTAGCATACTTGTTGTTAGCCACTGACGACAAAATATCTTGGCCG
GGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGG
TGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTTAGAATTGTCTTTTAA
TAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATTTGGCAATTCAATCGGAAAG
CCCTTGTCCTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTTTTTAGCGTTTGCAATCTTATCTT
TGAAATCAATATCGCCACGTTCAATAAGGGCAATTTTGCCTTTGACATCCTTAAAATCATCCTCTTTCGT
CCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATT
TCTTTATCTTGCTGATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAG
CAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGG
TAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGATGTCACAATGCTAACACCTTTTGATTTG
GCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGAAGGTTGGCATAAGCTAGTGCAGCATTACCAAAGCTCA
TATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGTAGTTACGAGCATAGTCTGC
TAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAA
GGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGA
CAGCGGTTTTACCATCTTTACTATAGTCGTGGTAATAAGCAACCTTATCATTGACCCACTCACCATAGGT
AATACCGTGATCTTTTTTGGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTAGATTTGTCTGTT
AAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCCTTGC
CTGCTTTTTCCTGCAGGGTTTTGACATGAGAAGGGTCGTTCAAATCCCTAATAGTCTCTTTTGAGGTTGC
TGGTATATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCCTTATCTGCTACTGTTTCTTCT
GCGTCATCAGGAGTTTGTGGGGGGTTAGTTTCCTTTGATGATGATGATGGTGCTTCCTCAGAAACCGCTG
TTTGTTGTGGGACTTCTACGGCTTGCTCGGTAGCAGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTC
TGATTGTGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAATGGTAGTTTTTGT
TTTTTACGCA
Protein Sequence 
>gi|21911262|ref|NP_665530.1| C5A peptidase precursor [Streptococcus pyogenes MGAS315] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVEVPQQTAVSEEAPSSSSKETNPPQTPDDAEETVADKANDLAPQAPAKTADIPATSKETIRDLNDPSHVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKSKARYQSKEDLEKAKKDHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNSKKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGDVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEAATSATFSAEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTNLLEGHSNKPEQDGSDQVPDKTPETKPEQDGSGQAPDKKPEAKPEQDGSGQAPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASARDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].