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scpA from Streptococcus pyogenes MGAS9429

Victor ID 4390
Gene Name scpA from Streptococcus pyogenes MGAS9429
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS9429
NCBI Gene ID 4061049
NCBI Protein GI 94989350
Locus Tag MGAS9429_Spy1720
Protein Accession YP_597451.1
Other Database IDs UniProtKB-ID: Q1JJR6_STRPC
UniRef100: UniRef100_P15926
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00001355FB
EMBL: CP000259
EMBL-CDS: ABF32907.1
RefSeq_NT: NC_008021.1
EnsemblGenome: EBSTRG00000045482.
EnsemblGenome_TRS: EBSTRT00000045489
EnsemblGenome_PRO: EBSTRP00000043706
GenomeReviews: CP000259_GR
KEGG: spk:MGAS9429_Spy1720
eggNOG: COG1404
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO370551:MGAS9429_SPY1720-MONOMER
Taxonomy ID 370551
Gene Starting Position 1670138
Gene Ending Position 1673641
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|94987631:1670138-1673641 Streptococcus pyogenes MGAS9429 chromosome, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAAGATATGAGCTACTAATCCAAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGAGCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTG
ACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCT
GGTTTAGCTTCTGGTTTTTTATCTGGTGTTTGACCTGAACCGTCTTGTTCTGGCTTATTAGAGTGGCCCT
CCAATAGCTTAGTCACTGGTGTATAAGTGATATTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGA
CATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCA
TTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAA
CCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGT
TGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAACTA
ATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGT
CCCAACGAGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAAC
TTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTA
GCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAG
CATATGGCTCGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACC
TGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCC
TTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTGTTTTTCAGAGCGTAAAACTGTA
ATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCT
ATCATAGATTGGTTTTTCTACGGCTGACAGATTGCCAAAATCACCTCGGAAACCAATATATGGAATGCTC
ATAAGCTCTTCTTTTGTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTT
GGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTGGCTGG
AATTGTGATTTTTTGCCATGATGCCTCATACAATACTTTAGGAGCCAAGGCAAAGTGTTTTCCATCTACT
TTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACAGTTACTG
TTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTCACATA
CATCGTTGCTGCTGAAGCTTTTTTAGCATCGACCGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCT
TTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTG
ATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAACAGTCCCATGATACCCGCTACTAATGG
CGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCG
GGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGG
TGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTGGGGATTGTCTTTTAA
TAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATTTGGCAATTCAATCGGGAAG
CCCTTGTCCTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTTTTTAGCGTTTGCAACCTTATCTT
TGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTGCCTTTGACATCCTTAAAATCATCCTCTTTCAT
CCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATT
TCTTTATCTTGCTGATCGTCTGTTTTGACCATAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAG
CAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGG
TAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTG
GCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGGAGGTTAGCGTAGGCTAGTGCAGCATTACCAAAGCTCA
TATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGTAGTTACGAGCATAGTCTGC
TAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAA
GGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGA
CAGCGGTTTTACCATCTTTGCTATAGTCGTGGTAATAAGCAACCTTATCATTGACCCACTCGCCATAGGT
AATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTGGTTTTGTCTGTT
AAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCCTTGC
CTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAGGTTGC
TGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCGTCATCTGCTATTGTTTCTTCT
GCGTCATCAGGAGTTTGTGGGGTTTTGGTTTCCTTTGATGATGGTACTTCCTCAGAAACCGCTGTTGGTT
GTGGGGTTTCTACGGCTTGTTCGGTAACAGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTG
TGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAATGGTAATTTTTGTTTTTTA
CGCA
Protein Sequence 
>gi|94989350|ref|YP_597451.1| C5A peptidase precursor [Streptococcus pyogenes MGAS9429] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPVTEQAVETPQPTAVSEEVPSSKETKTPQTPDDAEETIADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAMVKTDDQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKVANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKVLYEASWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSAVEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGEPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSGQTPDKKPEAKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].