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lsp from Streptococcus pyogenes MGAS2096

Victor ID 4395
Gene Name lsp from Streptococcus pyogenes MGAS2096
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS2096
NCBI Gene ID 4065311
NCBI Protein GI 94992200
Locus Tag MGAS2096_Spy0703
Protein Accession YP_600299.1
Other Database IDs UniProtKB-ID: LSPA_STRPB
UniRef100: UniRef100_Q1JCF3
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI000000AF69
EMBL: CP000261
EMBL-CDS: ABF35755.1
RefSeq_NT: NC_008023.1
EnsemblGenome: EBSTRG00000045106
EnsemblGenome_TRS: EBSTRT00000045113
EnsemblGenome_PRO: EBSTRP00000043419
GenomeReviews: CP000261_GR
KEGG: spj:MGAS2096_Spy0703
eggNOG: COG0597
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
BioCyc: SPYO370553:MGAS2096_SPY0703-MONOMER
Taxonomy ID 370553
Gene Starting Position 678609
Gene Ending Position 679067
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|94991497:678609-679067 Streptococcus pyogenes MGAS2096 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAGCAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGGTTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTGTT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|94992200|ref|YP_600299.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS2096] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].