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oppA

Victor ID 4368
Gene Name oppA
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3572677
NCBI Protein GI 71910063
Locus Tag M5005_Spy_0249
Protein Accession YP_281613.1
Other Database IDs UniProtKB-ID: Q490V0_STRP1
UniRef100: UniRef100_Q490V0
UniRef90: UniRef90_Q1J8G5
UniRef50: UniRef50_P31306
UniParc: UPI000057CD5E
EMBL: CP000017
EMBL-CDS: AAZ50868.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000027730.
EnsemblGenome_TRS: EBSTRT00000027730
EnsemblGenome_PRO: EBSTRP00000026748
GenomeReviews: CP000017_GR
KEGG: spz:M5005_Spy_0249
HOGENOM: HBG697241
OMA: SGAFAWA
ProtClustDB: CLSK883946
BioCyc: SPYO293653:M5005_SPY0249-MONOMER
Taxonomy ID 293653
Gene Starting Position 257516
Gene Ending Position 259486
Gene Strand (Orientation) +
Protein Name oligopeptide-binding protein
DNA Sequence 
>gi|71909814:257516-259486 Streptococcus pyogenes MGAS5005 chromosome, complete genome
TATGAAGAAAAGTAAATGGTTGGCAGCTGTAAGTGTTGCGATCTTGTCAGTATCCGCTTTGGCAGCTTGT
GGTAATAAAAATGCTTCAGGTGGCTCAGAAGCTACAAAAACCTACAAGTACGTTTTTGTTAACGATCCAA
AATCATTGGATTATATTTTGACTAATGGCGGTGGAACGACTGATGTGATAACACAAATGGTTGATGGTCT
TTTGGAAAACGATGAGTATGGTAATTTAGTACCATCACTTGCTAAAGATTGGAAGGTTTCAAAAGACGGT
CTGACTTATACTTATACTCTTCGCGATGGTGTCTCTTGGTATACGGCTGATGGTGAAGAATATGCCCCAG
TAACAGCAGAAGATTTTGTGACTGGTTTGAAGCACGCGGTTGACGATAAATCAGATGCTCTTTACGTTGT
TGAAGATTCAATAAAAAACTTAAAGGCTTACCAAAATGGTGAAGTAGATTTTAAAGAAGTTGGTGTCAAA
GCCCTTGACGATAAAACTGTTCAGTATACTTTGAACAAGCCTGAAAGCTACTGGAATTCAAAAACAACTT
ATAGTGTGCTTTTCCCAGTTAATGCGAAATTTTTGAAGTCAAAAGGTAAAGATTTTGGTACAACCGATCC
ATCATCAATCCTTGTTAATGGTGCTTACTTCTTGAGCGCCTTCACCTCAAAATCATCTATGGAATTCCAT
AAAAATGAAAACTACTGGGATGCTAAGAATGTTGGGATAGAATCTGTTAAATTGACTTACTCAGATGGTT
CAGACCCAGGTTCGTTCTACAAGAACTTTGACAAGGGTGAGTTCAGCGTTGCACGACTTTACCCAAATGA
CCCTACCTACAAATCAGCTAAGAAAAACTATGCTGATAACATTACTTACGGAATGTTGACTGGAGATATC
CGTCATTTAACATGGAATTTGAACCGTACTTCTTTCAAAAACACTAAGAAAGACCCTGCACAACAAGATG
CCGGTAAGAAAGCTCTTAACAACAAGGATTTTCGTCAAGCTATTCAGTTTGCTTTTGACCGAGCGTCATT
CCAAGCACAAACTGCAGGTCAAGATGCCAAAACAAAAGCCTTACGTAACATGCTTGTCCCACCAACATTT
GTGACCATTGGAGAAAGTGATTTTGGTTCAGAAGTTGAAAAGGAAATGGCAAAACTTGGGGATGAATGGA
AAGACGTTAACTTAGCTGATGCTCAAGATGGTTTCTATAATCCTGAAAAAGCAAAAGCTGAGTTTGCAAA
AGCCAAAGAAGCTTTAACAGCTGAAGGTGTAACCTTCCCAGTTCAATTAGATTACCCTGTTGACCAAGCA
AACGCAGCAACTGTTCAGGAAGCCCAGTCTTTCAAACAATCTGTTGAAGCATCTCTTGGTAAAGAGAATG
TCATTGTCAATGTTCTTGAAACAGAAACATCAACTCACGAAGCCCAAGGCTTCTATGCTGAGACCCCAGA
ACAACAAGACTACGATATCATTTCATCATGGTGGGGACCAGACTATCAAGATCCACGGACCTACCTTGAC
ATCATGAGTCCAGTAGGTGGTGGATCTGTTATCCAAAAACTTGGAATCAAAGCAGGTCAAAATAAGGATG
TTGTGGCAGCTGCAGGCCTTGATACCTACCAAACTCTTCTTGATGAAGCAGCAGCAATTACAGACGACAA
CGATGCGCGCTATAAAGCTTACGCAAAAGCACAAGCCTACCTTACAGATAATGCCGTAGATATTCCAGTT
GTGGCATTGGGTGGCACTCCACGAGTTACTAAAGCCGTTCCATTTAGCGGGGGCTTCTCTTGGGCAGGGT
CTAAAGGTCCTCTAGCATATAAAGGAATGAAACTTCAAGACAAACCTGTCACAGTAAAACAATACGAAAA
AGCAAAAGAAAAATGGATGAAAGCAAAGGCTAAGTCAAATGCAAAATATGCTGAGAAGTTAGCTGATCAC
GTTGAAAAATA
Protein Sequence 
>gi|71910063|ref|YP_281613.1| oligopeptide-binding protein [Streptococcus pyogenes MGAS5005] MKKSKWLAAVSVAILSVSALAACGNKNASGGSEATKTYKYVFVNDPKSLDYILTNGGGTTDVITQMVDGLLENDEYGNLVPSLAKDWKVSKDGLTYTYTLRDGVSWYTADGEEYAPVTAEDFVTGLKHAVDDKSDALYVVEDSIKNLKAYQNGEVDFKEVGVKALDDKTVQYTLNKPESYWNSKTTYSVLFPVNAKFLKSKGKDFGTTDPSSILVNGAYFLSAFTSKSSMEFHKNENYWDAKNVGIESVKLTYSDGSDPGSFYKNFDKGEFSVARLYPNDPTYKSAKKNYADNITYGMLTGDIRHLTWNLNRTSFKNTKKDPAQQDAGKKALNNKDFRQAIQFAFDRASFQAQTAGQDAKTKALRNMLVPPTFVTIGESDFGSEVEKEMAKLGDEWKDVNLADAQDGFYNPEKAKAEFAKAKEALTAEGVTFPVQLDYPVDQANAATVQEAQSFKQSVEASLGKENVIVNVLETETSTHEAQGFYAETPEQQDYDIISSWWGPDYQDPRTYLDIMSPVGGGSVIQKLGIKAGQNKDVVAAAGLDTYQTLLDEAAAITDDNDARYKAYAKAQAYLTDNAVDIPVVALGGTPRVTKAVPFSGGFSWAGSKGPLAYKGMKLQDKPVTVKQYEKAKEKWMKAKAKSNAKYAEKLADHVEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: oppA mutant caused less mortality and tissue damage than the wild-type strain when inoculated into BALB/c mice via an air pouch (Wang et al., 2005).
COG COG4166E, under E: Amino acid transport and metabolism
References
Wang et al., 2005: Wang CH, Lin CY, Luo YH, Tsai PJ, Lin YS, Lin MT, Chuang WJ, Liu CC, Wu JJ. Effects of oligopeptide permease in group a streptococcal infection. Infection and immunity. 2005; 73(5); 2881-2890. [PubMed: 15845494].