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scpA from Streptococcus pyogenes MGAS5005

Victor ID 4356
Gene Name scpA from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571155
NCBI Protein GI 71911528
Locus Tag M5005_Spy_1715
Protein Accession YP_283078.1
Other Database IDs UniProtKB-ID: C5AP_STRP1
UniRef100: UniRef100_P58099
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00001355FE
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34691.1
EMBL-CDS: AAZ52333.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000102
EnsemblGenome_TRS: EBSTRT00000000102
EnsemblGenome_PRO: EBSTRP00000000102
EnsemblGenome: EBSTRG00000028547
EnsemblGenome_TRS: EBSTRT00000028547
EnsemblGenome_PRO: EBSTRP00000027565
GenomeReviews: AE004092_GR
GenomeReviews
Taxonomy ID 293653
Gene Starting Position 1675256
Gene Ending Position 1678750
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|71909814:1675256-1678750 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ACTAATCTTCAGTGCGTTTTGTTTTAAAGATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAA
CTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTTTTGTTGATGCTTTT
GTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAGGAGTTTTAC
CTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTGACCTGAACC
GTCTTGTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGCTTGACCTGAACCGTCTTGTTCTGGTTTAGTT
TCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCTGGTTTATTAGAGTGGCCTTCCAATAGCT
TAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGACATTTTCAA
TGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCATTTGGAGAA
ATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAACCGGTTGGC
TGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGTTGCGACTTC
AGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAGCTAATCGGAGTG
TAGCGAACACGATAGGTGTATGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGTCCCAACGCG
TTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAACTTGCTCGGT
TACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTAGCATTACGC
AAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAGCATATGGCT
TGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAAGTACCTGCAAAAAT
GGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCTTTAATAATC
GTCCATGGATTAGACTCTGTAGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAACTGTAATCCATCAC
CATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCTATCATAGAT
TGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAAACCAATATAGGGAATACTCATAAGCTCT
TCTTTTGTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTGGGGCAAGCA
AGTCCTTGCTAAATTGACTAACATCGATTGGAATGGTGACTTGTTTGCTGCTATTGGCTGGAATTGTGAT
TTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGCAAAGAGTTTTCCATCTACTTTATCTGTT
TGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACTGTTACTGTTACTTCAA
ATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTCACATACATCGTTGC
TGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCTTTTTCATCT
TCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTGATGGTGTCA
TATCAGGATACTGTGTCTCATATTGCTTTTGCAACAGTCCCATGATACCCGCTACTAATGGCGCAGACAT
ACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCGGGTGCTGCA
ATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGGTGCCACTTG
CTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTGGGGATTCTCTTTTAATAAGAGACC
ATCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATTTGGCAATTCAATCGGGAAGCCCTTGTCC
TGATTGTCATAGATCAAGACTCCTACAGCACCAGCTTTTTTAGCGTTTGCAATCTTATCTTTGAAATCAA
TATCGCCACGTTCAATAAGGGCAATCTTACCTTTGACATCCTTAAAATCATCCTCTTTCATCCCACGATT
AGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATTTCTTTATCT
TGCTGATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAGCAACTGTCA
ATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGGTAGACGGGT
CTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTGGCATAGTCA
AAGGCTTTTTTGGTTTCGTCTGGAAGGTTGGCATAGGCTAGTGCAGCATTACCAAAGCTCATATTAATCA
CCTTAGCTCCCAAGTTGACAGCATCTATGATAGCTTGAGCGTAGTTACGAGCATAGTCTGCTAGTCCATT
TACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAAGGTTCTTTC
GTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGACAGCGGTTT
TACCATCTTTACTATAGTCGTGGTAATAAGCAACCTTATCATTGACCCACTCGCCATAGGTAATACCGTG
CTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTGGTTTTGTCTGTTAAGCGCCAC
GCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCTTTGCCTGCTTTTT
CCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAGGTTGCTGGTGTATC
AGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCGTCATCTGCTATTGTTTCTTCTGCGTCATCA
GGAGTTTGTGGGGTTTTGGTTTCCTTTGATGATGGTGCTTCCTCAGAAACCGCTGTTGGTTGTGGGGTTT
CTACAGCTTGTTCGGTAGCAGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTGTGCATTGAG
CAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAATGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|71911528|ref|YP_283078.1| C5A peptidase [Streptococcus pyogenes MGAS5005] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVETPQPTAVSEEAPSSKETKTPQTPDDAEETIADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIIDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKENPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKLFALAPKALYETSWQKITIPANSSKQVTIPIDVSQFSKDLLAPMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSGQAPDKKPETKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTKDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRTED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].