Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

M5005_Spy_1305

Victor ID 4360
Gene Name M5005_Spy_1305
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571619
NCBI Protein GI 71911118
Locus Tag M5005_Spy_1305
Protein Accession YP_282668.1
Other Database IDs UniProtKB-ID: Q99YQ7_STRP1
UniRef100: UniRef100_Q99YQ7
UniRef90: UniRef90_Q1J5M2
UniRef50: UniRef50_Q1JFS4
UniParc: UPI00000C7E4F
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34369.1
EMBL-CDS: AAZ51923.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
HSSP: P41789
EnsemblGenome: EBSTRG00000000563.
EnsemblGenome_TRS: EBSTRT00000000563
EnsemblGenome_PRO: EBSTRP00000000563
EnsemblGenome: EBSTRG00000027856.
EnsemblGenome_TRS: EBSTRT00000027856
EnsemblGenome_PRO: EBSTRP00000026874
GenomeReviews: AE004092
Taxonomy ID 293653
Gene Starting Position 1261760
Gene Ending Position 1263244
Gene Strand (Orientation) -
Protein Name two-component response regulator
DNA Sequence 
>gi|71909814:1261760-1263244 Streptococcus pyogenes MGAS5005 chromosome, complete genome
GTTACTGGTCGCCCTTGATGGCTTGGTAATTGTCCTTGTAACGATCTCTGAACTCTTTTGGCGATAAACC
ATTCAACTTTTTAAACATCTTGATAAAATAATGATTGGTATTGTAACCTGTTTCATAAGCAATTTCATTG
ATGGATTGGTTGGTGTAAAGCAATAACTGTTGCGCTTTTTGAATCCTAACATGATTTAAGTACTGGGTAA
AACTACGCTCGGTTTCATTTTTAAAGCATTGCCCTAAATAAACCCCATTGACATGTAACCTATCAGCGAT
AGCTTTAAGAGTTAATTCTTGATGGTATTCCTTGCGAATGCAATCAATGGTTTCACTAACTAAATCTGAA
TAGCGTTTTTCAGGGGAATTGTTCTGATTGGTGACATCCAACACTTTTTTTAGTTCCCTCAAAATGCAAT
CAATGGATTGGCTGTCATGAATAGTTTTTACCATGGACAGATAAGTCATTTTATCTAAAATGGGAAATTG
ACGATAAATGTCAGAAAACAACAAGAACGAAACATGCTTCACATCCTCTGGTGAAAAGTTCAAGGTCTTC
ATCTCGTCAAAAATAGCTTCTAATTTAGACAAGATTGTAGGTTCGTCCCCAATCATCAACGCCTTGTTAA
AAGCAAAGAACTGCAAACGGGACTCTGGTAGTTCAATTTTGGACTTATCTTTTGCTCTAATTGGTGACAC
TTCACAATTGTAAAAGAGGCTCTTAAGCACCTGATTGTAGCTTTCATAAACATTTTCCCAGTCATCAACT
GTTTCTCCCAAAATAAGTTGATGCATGTTTCTTGAGAATCGCTTTTGTAGATCATAGGTAAACGCCTTGG
CTTGATCAGTTTTACCAAGTAGGACAGCCAGATAAACCTTCTTATCTTCTTCTTTTTTGAGATAAAAAGG
CTGACCTTCTCGTTCAAAATAAGCATCGATGGCTGCTTGCCACTCTTGACAGTCCAAATACAGCACTGTA
AAACCAGTTAAAGCAGCCGCTGGCAAGCCTTGACTTAACTGCTGAAATTCTTTCTCACTCAATTCATCTG
TAAGCCAAAGGGTCAAAAGGCTGTCATGATAGGCTTCTTGCCGGATTGATTCTGCCTGCTGGGCATCCAA
CCAGTCTTTAAATTGTTTCATTTTAGCCTGTAATTCTGCCTTATCAACAGGTTTTAACAAATACCCCTTG
GTTTCTAATTCCATAGCCTTTTGCACATAGGAGAATTCTTGATAACCAGATAAAATCAAGGTTTGTAGCT
GAGGATGATAGGTTTTAGCTGCTTCTATTAAATCCAGTCCTGTCATTCCAGGCATGGTAACATCTGAAAT
CATGACATCCACTGGGTACTGAGTCAAATAGGCTAAGGCTTCCTTGCCTGATCTTGCTGTTTGAACCACT
TCAAATCCAAGTGCCTGCCAATCAATAATCATGGTGAGCCCTTGTAAAATCATGTATTCATCGTCAACTA
ATAGTACCTTATACA
Protein Sequence 
>gi|71911118|ref|YP_282668.1| two-component response regulator [Streptococcus pyogenes MGAS5005] MYKVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVDVMISDVTMPGMTGLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDWLDAQQAESIRQEAYHDSLLTLWLTDELSEKEFQQLSQGLPAAALTGFTVLYLDCQEWQAAIDAYFEREGQPFYLKKEEDKKVYLAVLLGKTDQAKAFTYDLQKRFSRNMHQLILGETVDDWENVYESYNQVLKSLFYNCEVSPIRAKDKSKIELPESRLQFFAFNKALMIGDEPTILSKLEAIFDEMKTLNFSPEDVKHVSFLLFSDIYRQFPILDKMTYLSMVKTIHDSQSIDCILRELKKVLDVTNQNNSPEKRYSDLVSETIDCIRKEYHQELTLKAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSINEIAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYKDNYQAIKGDQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: In a murine skin infection model, an insertion mutation in the response regulator gene, trxR (M5005_Spy_1305), led to a significant reduction in lesion size, lesion severity, and lethality (Leday et al., 2008).
COG COG4753T, under T: Signal transduction mechanisms
References
Leday et al., 2008: Leday TV, Gold KM, Kinkel TL, Roberts SA, Scott JR, McIver KS. TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus. Infection and immunity. 2008; 76(10); 4659-4668. [PubMed: 18678666].