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spyM18_1238

Victor ID 4314
Gene Name spyM18_1238
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS8232
NCBI Gene ID 994087
NCBI Protein GI 19746213
Locus Tag spyM18_1238
Protein Accession NP_607349.1
Other Database IDs UniProtKB-ID: Q8P0S0_STRP8
UniRef100: UniRef100_Q8P0S0
UniRef90: UniRef90_Q5W1M4
UniRef50: UniRef50_Q5W1M4
UniParc: UPI00000D9971
EMBL: AE009949
EMBL-CDS: AAL97848.1
RefSeq_NT: NC_003485.1
HSSP: P13380
EnsemblGenome: EBSTRG00000029568.
EnsemblGenome_TRS: EBSTRT00000029568
EnsemblGenome_PRO: EBSTRP00000028490
GenomeReviews: AE009949_GR
KEGG: spm:spyM18_1238
HOGENOM: HBG697988
OMA: QIHSING
ProtClustDB: CLSK449847
BioCyc: SPYO186103:SPYM18_1238-MONOMER
Taxonomy ID 186103
Gene Starting Position 1041615
Gene Ending Position 1042403
Gene Strand (Orientation) -
Protein Name putative exotoxin precursor (SpeL)
DNA Sequence 
>gi|19745201:1041615-1042403 Streptococcus pyogenes MGAS8232, complete genome
ATTAATTTTCTTTGTTTGTGAATAAATAGACATCAATATGACTCTTTTTGTCTATATCTATCAAATTATT
ATATCTATAATCTGGGTATTTAAATAAGTCAGCACCTTCCTCTTTCTCGCCTGAGCCGTGAAATTCCCAG
TTTCCAGATAGAACTTTGGAATCATACTGATAAAGTTTTATTTCATCGTTCAGCATAAATGATTTTCTCA
ATCTAACATCAACTTCCTGGAAGGTAACGGGAGATTTTTCAAAAGTTATTTTATATTTCGAGGTATCATC
TTTTTTATGCCCATCAATAAAAACGTTCATGTAAATCGTTTTTCCGGCTCCTTTTCTCTCATTAACTTTA
ACGAGACCACCATTGATTGAATGTATTTGATCTTTTGAAAATACTTCAGCTGATAATGCAAGACCAAAAA
CATCGACATTATCTCCAACATTAAATTTACCTTCTACAGATGGGTGTAGGTTACTTGATATTATAAAATT
ATAATCATCAAATTCCCATACTTTAGTTTTATGCTGAGCATCCATAATAACTTGCGTCCCTCTTTTTCCA
GTAATGGGTTTATTCACTTTTTTTATAGTATCTCTATTATAAATTTCTCTTAAGGTAGTAGGGGATAATG
TTTTATCTACATCCCACCTTGGAGAGTATATATCCTTAATATTAATAGTCTCTTCCGCAGAAACCATCCT
AACAGAAAATACCATCAATGACAATACTACTATAAAAAAAGTAGTTGACATATTAACCAAACGACAATTC
TGGTGTAAAAAAATTCTCA
Protein Sequence 
>gi|19746213|ref|NP_607349.1| exotoxin SpeL [Streptococcus pyogenes MGAS8232] MRIFLHQNCRLVNMSTTFFIVVLSLMVFSVRMVSAEETINIKDIYSPRWDVDKTLSPTTLREIYNRDTIKKVNKPITGKRGTQVIMDAQHKTKVWEFDDYNFIISSNLHPSVEGKFNVGDNVDVFGLALSAEVFSKDQIHSINGGLVKVNERKGAGKTIYMNVFIDGHKKDDTSKYKITFEKSPVTFQEVDVRLRKSFMLNDEIKLYQYDSKVLSGNWEFHGSGEKEEGADLFKYPDYRYNNLIDIDKKSHIDVYLFTNKEN
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Purified SpeL is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeL was lethal in two animal models of streptococcal toxic shock (Smoot et al., 2002).
References
Smoot et al., 2002: Smoot LM, McCormick JK, Smoot JC, Hoe NP, Strickland I, Cole RL, Barbian KD, Earhart CA, Ohlendorf DH, Veasy LG, Hill HR, Leung DY, Schlievert PM, Musser JM. Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infection and immunity. 2002; 70(12); 7095-7104. [PubMed: 12438391].