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lsp from Streptococcus pyogenes MGAS10270

Victor ID 4392
Gene Name lsp from Streptococcus pyogenes MGAS10270
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10270
NCBI Gene ID 4063392
NCBI Protein GI 94990202
Locus Tag MGAS10270_Spy0693
Protein Accession YP_598302.1
Other Database IDs UniProtKB-ID: LSPA_STRPD
UniRef100: UniRef100_Q1JHH8
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI0000D75131
EMBL: CP000260
EMBL-CDS: ABF33758.1
RefSeq_NT: NC_008022.1
EnsemblGenome: EBSTRG00000039477
EnsemblGenome_TRS: EBSTRT00000039479
EnsemblGenome_PRO: EBSTRP00000037963
GenomeReviews: CP000260_GR
KEGG: sph:MGAS10270_Spy0693
eggNOG: COG0597
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
BioCyc: SPYO370552:MGAS10270_SPY0693-MONOMER
Taxonomy ID 370552
Gene Starting Position 670629
Gene Ending Position 671087
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|94989509:670629-671087 Streptococcus pyogenes MGAS10270 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATATGGAAGCAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGATTC
ATTTAGACTTTATGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|94990202|ref|YP_598302.1| Lipoprotein signal peptidase [Streptococcus pyogenes MGAS10270] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFMDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].