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mga from Streptococcus pyogenes NZ131

Victor ID 4441
Gene Name mga from Streptococcus pyogenes NZ131
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985280
NCBI Protein GI 209560150
Locus Tag Spy49_1673c
Protein Accession YP_002286622.1
Other Database IDs UniProtKB-ID: B5XIS8_STRPZ
UniRef100: UniRef100_B5XIS8
UniRef90: UniRef90_Q1J4H5
UniRef50: UniRef50_P19401
UniParc: UPI00004C24B3
EMBL: CP000829
EMBL-CDS: ACI61927.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000049980.
EnsemblGenome_TRS: EBSTRT00000049988
EnsemblGenome_PRO: EBSTRP00000059944
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_1673c
HOGENOM: HBG698420
OMA: NWIHLLD
ProtClustDB: CLSK443224
Taxonomy ID 471876
Gene Starting Position 1656519
Gene Ending Position 1658120
Gene Strand (Orientation) -
Protein Name M protein trans-acting positive regulator (Mga)
DNA Sequence 
>gi|209558587:1656519-1658120 Streptococcus pyogenes NZ131 chromosome, complete genome
CCTATGATGATGTTGCTTGTTTAACTGAATTGTCTGGCTTTTCTGGTTTTTGTACCTCTTTGTCACTATG
AGATTTTGAAGAGGAAGGGGCTTCGAGGTTTTTGACCATAACGTTGTTATCTGTGAAACTAACGTTCAAA
AATTCGTTTAATCTATCAATAATAGCTTCTGGGATCATCTTGTAGAAAAAGAAAATCTCTAACTCTTCGC
TTTTACCCACCATAACATCTGTCACGATAACATCGTATTGTTTTTCAATCTCTACTAGATCAATTGTCAG
ACAATCTAACTCATCAAAATTAGTAATGCTGAAAAACTCACCGATGTACTTTTTCAAAAAATTACCGACA
CTATTGTAACTTCTCTCTATCACTAGGAGTCGTACTTTTTCATCTTTTTGATTTACTTTTAAGAAACTAT
TTTCCCAGGTAATAAAGAAACAATAAGTGAGCTGATTGATCAGTTCTTTGCTAACTTGAGCATTATCTGC
CTGCATCAGCTTCTCGACACTTGTCACAAAGGCCTCATAGATACGAGGGTGTTCTTTTTGGTAAAAATTC
AGGTAACTCTTTTTATAATCAAACAGCAAATAATTGGCTGTAATGTCTTCTTCGTCTAACACCGAAGCGT
TATGGAGGGTTACGGCAACTTCGTATTTATTGGTGATGCTGAGATTGAGCTTGATTTCCATCTCATCTAA
TAGATGGATCCAGTTGGTTACTTGCCTGCCTCCTGATGTTGGGTCTTGATTGATAATCTCAAAAGCACAG
CCAATTTCTAGCTTGTCGTTAAGGTGGTTAGAAAACATTTCAGCTATGGTATACTCGTCGAGATGTAACC
CAAATTTGAGGTAGAACAAGCGAGAAAGATCCTGGATTTCTGAGGAATGTTGGATAAGTTGAGAAAAACG
GTGACTGGTTTTTTTATTGTTATAACTGCAAGAATACCCCTTGTAGTAACGGATCAAGTTGACGCCACTT
AAGATTTTTAAGTGCTGAAATAGCGTAAAATGAACTTTGACATCTACTTCTTTGATCAATAAGCTCAATA
GGCGTTCACAGTTTTTCAGGTTTAAAATGTCCCCAAATGGCCATTCTGAGATTTTATAGGCTTCTGAAAA
ATACTTGAGGTAAAACAGGCGGATTTGCCTCTCATCTCCTGATACCTGCACTGGACTTGTCACGATACTA
ATAGCAAAGGTATGAGACAAGTAAGTGTTGGTTTTTTTGATGAGGCGTTTGAGGGTAGATAAACTGACAA
ACAGCTCTTCAGCTAACTCTTCTAAGGAACTAAAGTCTCTGAAAAACAAAAGCTCCAGTAATTTCAAAGA
AGGCGATTCTCGAAGAGCTTTTTGATAGACCTCTTGTAGCCCACAACACTGGTGATACCAAATGTTAATA
TAGCCGTCTTTGTAGGTAATTCCACCTACTTCTTTCATGAACTGCATATTAGTGAGGCATGACTGTAATG
TTAACATGGAAATATTGAGAGCCTTGCTAAGCTCCTTATCTTTAACTCCGATAGCATTGGAGTTTTCTGT
TAAATATGAGATCAGTTTCAATTCTCTCCATTGTTGGCTAGTAAATAATTTACTTACATGCA
Protein Sequence 
>gi|209560150|ref|YP_002286622.1| M protein trans-acting positive regulator (Mga) [Streptococcus pyogenes NZ131] MHVSKLFTSQQWRELKLISYLTENSNAIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIWYHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYLSHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKEVDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYLKFGLHLDEYTIAEMFSNHLNDKLEIGCAFEIINQDPTSGGRQVTNWIHLLDEMEIKLNLSITNKYEVAVTLHNASVLDEEDITANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEKLMQADNAQVSKELINQLTYCFFITWENSFLKVNQKDEKVRLLVIERSYNSVGNFLKKYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDRLNEFLNVSFTDNNVMVKNLEAPSSSKSHSDKEVQKPEKPDNSVKQATSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008).
References
Luo et al., 2008: Luo F, Lizano S, Banik S, Zhang H, Bessen DE. Role of Mga in group A streptococcal infection at the skin epithelium. Microbial pathogenesis. 2008; 45(3); 217-224. [PubMed: 18588968].