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grab

Victor ID 4361
Gene Name grab
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571808
NCBI Protein GI 71910919
Locus Tag M5005_Spy_1106
Protein Accession YP_282469.1
Other Database IDs UniProtKB-ID: Q7DAL7_STRP1
UniRef100: UniRef100_Q9X5C4
UniRef90: UniRef90_Q1J628
UniRef50: UniRef50_Q1J628
UniParc: UPI00000D4514
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34185.1
EMBL-CDS: AAZ51724.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000115.
EnsemblGenome_TRS: EBSTRT00000000115
EnsemblGenome_PRO: EBSTRP00000000115
EnsemblGenome: EBSTRG00000027540.
EnsemblGenome_TRS: EBSTRT00000027540
EnsemblGenome_PRO: EBSTRP00000026558
GenomeReviews: AE004092_GR
GenomeRev
Taxonomy ID 293653
Gene Starting Position 1079236
Gene Ending Position 1079889
Gene Strand (Orientation) -
Protein Name protein G-related alpha 2M-binding protein
DNA Sequence 
>gi|71909814:1079236-1079889 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ACTAATTTTCTTTGCACTTTGAACTTACAACTAACACACCTGTACTTACCATTATTGCAAGCGCAGCAGC
TGTAAAGAATGGGTTAGACTCTTCACCAGTTGTAGGAAGGGTATTAACGTTTTGTCTTTCTTCTTTTTTA
ACTACAGGTTTTGTATCTTTAGTTTTCTTAACATCTAAAGCGATTGGAGTTGCTGCTTTTTCCCAGGCGT
CACTAGCAGCGTTATCTGATTGAACTACTTCAGCTTCTTCTGATTGTAAAGCGTCTGTTTGATCCGCCAA
TGCTTCTAAGGCGTCACTAGCAGCGTTATCCGCTTTAACAACCGCAGCTTCTTCTGATTGTAAAGCGTCT
GTTTGATCCGCTAATGCTTCTAAGGCATCTGAACTTGCTGCTTCTATAGCTGTCGTAGCTTCTTTATCCT
CAATAGCTTGTTTTTTTAATTCATCAATGGCTCTTTCTTCATTACGTAATGCCAGTTTTTCTGGAGCATT
GCCAAGAAGATTAGTTAAGGTTCCGCCATTTGGAATAATTCGAGGCTGTTCGATAGGTGAGTCAACAGCA
GATACTGTTGAACCGACTAATACTGATGCTGACACCGCAACTAATCCAAAAGCTGATCTACGCAAAAAGC
ATTTCACTTTTATTTCTTTTCCCA
Protein Sequence 
>gi|71910919|ref|YP_282469.1| protein G-related alpha 2M-binding protein [Streptococcus pyogenes MGAS5005] MGKEIKVKCFLRRSAFGLVAVSASVLVGSTVSAVDSPIEQPRIIPNGGTLTNLLGNAPEKLALRNEERAIDELKKQAIEDKEATTAIEAASSDALEALADQTDALQSEEAAVVKADNAASDALEALADQTDALQSEEAEVVQSDNAASDAWEKAATPIALDVKKTKDTKPVVKKEERQNVNTLPTTGEESNPFFTAAALAIMVSTGVLVVSSKCKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: grab mutant is attenuated in mice when injected intraperitoneally (Rasmussen et al., 1999).
References
Rasmussen et al., 1999: Rasmussen M, Müller HP, Björck L. Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin. The Journal of biological chemistry. 1999; 274(22); 15336-15344. [PubMed: 10336419].