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lsp from Streptococcus pyogenes MGAS315

Victor ID 4328
Gene Name lsp from Streptococcus pyogenes MGAS315
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1008870
NCBI Protein GI 21910092
Locus Tag SpyM3_0556
Protein Accession NP_664360.1
Other Database IDs UniProtKB-ID: LSPA_STRP3
UniRef100: UniRef100_Q1JCF3
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI000000AF69
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM79163.1
EMBL-CDS: BAC64393.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
EnsemblGenome: EBSTRG00000033695
EnsemblGenome_TRS: EBSTRT00000033695
EnsemblGenome_PRO: EBSTRP00000032434
EnsemblGenome: EBSTRG00000035543
EnsemblGenome_TRS: EBSTRT00000035543
EnsemblGenome_PRO: EBSTRP00000034193
GenomeReviews: AE014074_GR
GenomeReviews
Taxonomy ID 198466
Gene Starting Position 609849
Gene Ending Position 610307
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|21909536:609849-610307 Streptococcus pyogenes MGAS315 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGGTTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|21910092|ref|NP_664360.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS315] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].