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M6_Spy0741

Victor ID 4349
Gene Name M6_Spy0741
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10394
NCBI Gene ID 2941480
NCBI Protein GI 50914087
Locus Tag M6_Spy0741
Protein Accession YP_060059.1
Other Database IDs UniProtKB-ID: Q5XCI7_STRP6
UniRef100: UniRef100_Q5XCI7
UniRef90: UniRef90_Q5XCI7
UniRef50: UniRef50_P62561
UniParc: UPI000040220F
EMBL: CP000003
EMBL-CDS: AAT86876.1
RefSeq_NT: NC_006086.1
EnsemblGenome: EBSTRG00000037899.
EnsemblGenome_TRS: EBSTRT00000037901
EnsemblGenome_PRO: EBSTRP00000036474
GenomeReviews: CP000003_GR
KEGG: spa:M6_Spy0741
HOGENOM: HBG692952
OMA: DSTMASS
ProtClustDB: CLSK275961
BioCyc: SPYO286636:M6_SPY0741-MONOMER
Taxonomy ID 286636
Gene Starting Position 746086
Gene Ending Position 746856
Gene Strand (Orientation) -
Protein Name SpeA variant
DNA Sequence 
>gi|50913346:746086-746856 Streptococcus pyogenes MGAS10394 chromosome, complete genome
GTTACTTCGTTGTTAGGTAGACTTCAATTTGACTTGTGCTTGAGTCAAGCGTCTCATTATCTTTATATAT
CATAAGATACTTAACTTGATTAAATTCTGGTTCAGGAAAAAAATCAAACCAAAAGGTTTCTTTATCCTTA
GATATGAACTTTATATATCCAGTTTCGTATTTAGATGGTCCATTAGTATATAGTTGCTTGTTATCTGTAA
GGTGTTTTCTAACTTTATAGTCTAATTCTTGAGCAGTTACCATTTTTTTACTTGTTTCAATATCAAATGA
TAGACTTTGGATACCATCAATTGATACTTTAACAAGTATATTTTTAGGAATTTCTAAATGATTCCCTTCA
TGATTTGTTACCCCTCCATAAATACACGCTCTTCTTTTTGCATTTCTACATAAGTAACAGTGATAGTAAT
ATTCTACACCGTAAATGTCAACGTTTTTATTCTTAAATAAGGTTGACATCTCTCGGTTCTTGAGTTCGGT
TTTTAACTTATCATAATTTAGTCCTGAAACATTATATATCAAGTCATGAGATAAAAGTTGATCAACAGAT
TTTACATTCTCATGAACGACAGGATCACCCTCATAAAGAAAATATATATTTTGAAGGTTTTTAACTAAAC
TAGATCTGTGAAGTTGGCTTGGGTTGGGGTCTTGTTGAGCAAATACTTCTTGTGAGGTTGTTAGCCCAAG
GAATATTGCTAAAACAAAATATACTATCTTTTTCAGTACTTTTTTATTGTTTTTCATTAATATTTTCTCC
A
Protein Sequence 
>gi|50914087|ref|YP_060059.1| SpeA variant [Streptococcus pyogenes MGAS10394] MEKILMKNNKKVLKKIVYFVLAIFLGLTTSQEVFAQQDPNPSQLHRSSLVKNLQNIYFLYEGDPVVHENVKSVDQLLSHDLIYNVSGLNYDKLKTELKNREMSTLFKNKNVDIYGVEYYYHCYLCRNAKRRACIYGGVTNHEGNHLEIPKNILVKVSIDGIQSLSFDIETSKKMVTAQELDYKVRKHLTDNKQLYTNGPSKYETGYIKFISKDKETFWFDFFPEPEFNQVKYLMIYKDNETLDSSTSQIEVYLTTK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits (Lee and Schlievert, 1989).
References
Lee and Schlievert, 1989: Lee PK, Schlievert PM. Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness. Journal of clinical microbiology. 1989; 27(8); 1890-1892. [PubMed: 2504778].