Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

lsp from Streptococcus pyogenes MGAS5005

Victor ID 4363
Gene Name lsp from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3572266
NCBI Protein GI 71910450
Locus Tag M5005_Spy_0637
Protein Accession YP_282000.1
Other Database IDs UniProtKB-ID: LSPA_STRP1
UniRef100: UniRef100_Q9A0D2
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI00000C7D09
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK33759.1
EMBL-CDS: AAZ51255.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000635
EnsemblGenome_TRS: EBSTRT00000000635
EnsemblGenome_PRO: EBSTRP00000000635
EnsemblGenome: EBSTRG00000028306
EnsemblGenome_TRS: EBSTRT00000028306
EnsemblGenome_PRO: EBSTRP00000027324
GenomeReviews: AE004092_GR
GenomeReviews
Taxonomy ID 293653
Gene Starting Position 639644
Gene Ending Position 640102
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|71909814:639644-640102 Streptococcus pyogenes MGAS5005 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGATTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTATT
ATTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|71910450|ref|YP_282000.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS5005] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].