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fba from Streptococcus pyogenes MGAS5005

Victor ID 4359
Gene Name fba from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571297
NCBI Protein GI 71911420
Locus Tag M5005_Spy_1607
Protein Accession YP_282970.1
Other Database IDs UniProtKB-ID: ALF_STRP1
UniRef100: UniRef100_P68905
UniRef90: UniRef90_P68905
UniRef50: UniRef50_P0A4S2
UniParc: UPI0000165A3F
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34600.1
EMBL-CDS: AAZ52225.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000001088
EnsemblGenome_TRS: EBSTRT00000001088
EnsemblGenome_PRO: EBSTRP00000001088
EnsemblGenome: EBSTRG00000027793
EnsemblGenome_TRS: EBSTRT00000027793
EnsemblGenome_PRO: EBSTRP00000026811
GenomeReviews: AE004092_GR
GenomeReviews:
Taxonomy ID 293653
Gene Starting Position 1564119
Gene Ending Position 1565000
Gene Strand (Orientation) -
Protein Name fructose-bisphosphate aldolase
DNA Sequence 
>gi|71909814:1564119-1565000 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ATTATGCTTTGTTAGCTGATCCGAAAACATCGATACGTTCTTCAACAGCACCTTGAACAGCTTTCATACC
TGGAGCCAAGAATTTACGTGGGTCAAATAATTTTTTACCATCATATTCTGCTTCGTTAGCTTCGTAGTTA
CGAGCAAATTCACGAGTTGCGTTAGAGAAAGCGATTTGACTTTCAGTGTTAACATTAACTTTAGCAACAC
CAAGACGGATTGCTTCTTTGATTTGATCGTCAGGAATACCAGAACCACCGTGCAATACGATTGGGAAACC
TGGTACAGCTGCTGTTAATTTTTCTAAGTGGTCAAGAGCAAGACCTTCCCAGTTTTCTGGGTATGGACCG
TGGATGTTACCGATACCAGCTGCCAAGAAGTCAATTCCAGTTTCAACCATTGCTTTAGCATCTTCGATTG
GAGCGAGCTCACCTTTACCGATGATACCGTCTTCTTCACCACCGATTGTACCAACTTCAGCTTCAACTGA
AACGCCTTTAGCATGTGCAATTTTAACAACTTCTGCAGTTTTAGCAAGGTTTTCTTCAACTGGAAGGTGT
GAACCGTCAAACATGATTGAAGTGTAACCTACTTCGATACACTCAAGAGCATCTTCGTAGTGACCATGAT
CAAGGTGGATAGCAACAGGAACAGTGATACCCATTGACTCAACAAGGTTAGTAATAAGAGATTGACATAC
TTTATAACCACCCATGTATTTTGCTGCACCCATTGATGTTTGGATAAGAACTGGAGCTTGTTTAGCTTCT
GCTGCACGCAAGATTGCTTGAGTCCACTCTAAGTTGTTTGTGTTAAATCCACCAACAGCATATCCGTTTT
CACGAGCTGCTTGGACAAATTTTTCTGCTGAAACGATTGCCA
Protein Sequence 
>gi|71911420|ref|YP_282970.1| fructose-bisphosphate aldolase [Streptococcus pyogenes MGAS5005] MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFSNATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001).
COG COG0191G, under G: Carbohydrate transport and metabolism
References
Terao et al., 2001: Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Molecular microbiology. 2001; 42(1); 75-86. [PubMed: 11679068].