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speJ from Streptococcus pyogenes MGAS5005

Victor ID 4366
Gene Name speJ from Streptococcus pyogenes MGAS5005
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3572567
NCBI Protein GI 71910169
Locus Tag M5005_Spy_0356
Protein Accession YP_281719.1
Other Database IDs UniProtKB-ID: Q99QN1_STRP1
UniRef100: UniRef100_Q7BAE3
UniRef90: UniRef90_Q7BAE3
UniRef50: UniRef50_Q7BAE3
UniParc: UPI00000D5E37
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK33456.1
EMBL-CDS: AAZ50974.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000082.
EnsemblGenome_TRS: EBSTRT00000000082
EnsemblGenome_PRO: EBSTRP00000000082
EnsemblGenome: EBSTRG00000028920.
EnsemblGenome_TRS: EBSTRT00000028920
EnsemblGenome_PRO: EBSTRP00000027938
GenomeReviews: AE004092_GR
GenomeRev
Taxonomy ID 293653
Gene Starting Position 362033
Gene Ending Position 362731
Gene Strand (Orientation) -
Protein Name exotoxin type J precursor
DNA Sequence 
>gi|71909814:362033-362731 Streptococcus pyogenes MGAS5005 chromosome, complete genome
CTTATTTAGTCCAAAGGTAAATATCAAAATGGCTGAAATCTTTCATATTTATAGTCTTATTGTCTTTATA
TTTTTTAAAAATATCACTCCTTGTACTAGATGAGGTTGCATCATATAAGTTAAAACTTTCATGTTTATTG
CCATTGATCGCAATTTCTAATTGCCCTTTTATGTATGGAGAATTAGGATCATAAATTTTGTATGTTTGCA
TAAGATATTGTCTGATTTTGAAGTCAAATTCTTGAATCGTAAAAATAGGTTTATCTATTTTTATGGGATT
TATTAGTGTTTTTTGCTGGACTCCATCTATTAGTAAATTACCTACAATTTTACTATTTTCCGAATTACTG
TTTACTGATGGTGTAACCCCACCATATATATAATAAACATCATAACGAGTAAATATGTACGGAAGACCAA
AAATATTTACTTTTTGATTTTTCGTAAACTTTGTTGTAATATAGCTCTCGACCTCAGAATCAACTGAAAA
ATTTTTCTTTTTATAACTGGAAATATCAATATAAAAATCATGAGTAGTCAAGTAATCAATATTACAATTC
GTATAATCTACTGGTATGATTTCGTATGCGTAATTTAATTGTAGCTTAACGTCTTTAATATTTTCACTAT
CTGATTTTACACTTCCGTACCCATGAAAGATTATTATAACTAAAATTATTGTTTTTATTATTCTTTTCA
Protein Sequence 
>gi|71910169|ref|YP_281719.1| exotoxin type J [Streptococcus pyogenes MGAS5005] MKRIIKTIILVIIIFHGYGSVKSDSENIKDVKLQLNYAYEIIPVDYTNCNIDYLTTHDFYIDISSYKKKNFSVDSEVESYITTKFTKNQKVNIFGLPYIFTRYDVYYIYGGVTPSVNSNSENSKIVGNLLIDGVQQKTLINPIKIDKPIFTIQEFDFKIRQYLMQTYKIYDPNSPYIKGQLEIAINGNKHESFNLYDATSSSTRSDIFKKYKDNKTINMKDFSHFDIYLWTK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001).
References
McCormick et al., 2001: McCormick JK, Pragman AA, Stolpa JC, Leung DY, Schlievert PM. Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen. Infection and immunity. 2001; 69(3); 1381-1388. [PubMed: 11179302].