Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 4271 SPy_0019 Streptococcus pyogenes M1 GAS 900379 15674263 SPy_0019 AE004092 NP_268436 putative secreted protein Virulence factor MUTATION: SPy_0019 (cdhA) mutant has severe cell division, growth defects and is attenuated in mice [Ref6929:Pancholi et al., 2010]. COG3883S, under S: Function unknown 20643653 4272 nga Streptococcus pyogenes M1 GAS 900488 15674370 SPy_0165 NP_268544.1 NAD glycohydrolase Virulence factor MUTATION: nga mutant is attenuated in mice [Ref6930:Tatsuno et al., 2010]. 20470439 4273 speJ from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900684 15674561 SPy_0436 NP_268735.1 putative exotoxin (superantigen) Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. 11179302 4274 sagA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900920 15674789 SPy_0738 NP_268963.1 streptolysin S associated protein Virulence factor MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. 9529097 4275 lsp from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900995 15674864 SPy_0826 NP_269038.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4276 dltA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901401 15675261 SPy_1312 NP_269435.1 D-alanine--poly(phosphoribitol) ligase subunit 1 Virulence factor MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells [Ref6934:Kristian et al., 2005]. COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 16166534 4277 scpA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901674 15675796 SPy_2010 NP_269970.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4278 sic Streptococcus pyogenes M1 GAS 901676 15675798 SPy_2016 NP_269972.1 inhibitor of complement-mediated lysis Virulence factor MUTATION: sic mutant was phagocytosed and killed by human polymorphonuclear leukocytes significantly better than the wild-type strain [Ref6936:Hoe et al., 2002]. 12032337 4279 emm1 Streptococcus pyogenes M1 GAS 901677 15675799 SPy_2018 NP_269973.1 M protein type 1 Virulence factor MUTATION: emm1 mutant had greatly reduced invasion of HeLa cells [Ref6937:Dombek et al., 1999]. COG1196D, under D: Cell cycle control, cell division, chromosome partitioning 10048029 4280 mga from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901678 15675800 SPy_2019 NP_269974.1 M protein trans-acting positive regulator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4281 speB from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901690 15675811 SPy_2039 NP_269985.1 pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. 18796357 4282 gidA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901831 15675920 SPy_2185 NP_270094.1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Virulence factor MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection [Ref6940:Cho and Caparon, 2008]. COG0445D, under D: Cell cycle control, cell division, chromosome partitioning 18426891 4283 SPy_1633 Streptococcus pyogenes M1 GAS 901885 15675508 SPy_1633 AE004092 NP_269682 hypothetical protein Virulence factor MUTATION: SPy_1633 (cvfA) mutant is attenuated in mice [Ref6941:Kang et al., 2010]. COG1418R, under R: General function prediction only 20385762 4284 SPy_1718 Streptococcus pyogenes M1 GAS 901955 15675569 SPy_1718 AE004092 NP_269743 putative esterase Virulence factor MUTATION: SPy_1718 (sse) mutant is attenuated in mice [Ref6942:Zhu et al., 2009]. COG0657I, under I: Lipid transport and metabolism 19805529 4285 fba from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 902096 15675705 SPy_1889 NP_269879.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. COG0191G, under G: Carbohydrate transport and metabolism 11679068 4313 spyM18_1239 Streptococcus pyogenes MGAS8232 993646 19746214 spyM18_1239 NP_607350.1 putative exotoxin precursor (SpeM) Virulence factor TOXIN: Purified SpeM is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeM was lethal in one model of streptococcal toxic shock [Ref6952:Smoot et al., 2002]. 12438391 4314 spyM18_1238 Streptococcus pyogenes MGAS8232 994087 19746213 spyM18_1238 NP_607349.1 putative exotoxin precursor (SpeL) Virulence factor TOXIN: Purified SpeL is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeL was lethal in two animal models of streptococcal toxic shock [Ref6952:Smoot et al., 2002]. 12438391 4315 mga from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 994370 19746912 spyM18_2077 NP_608048.1 positive regulatory protein Mga Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4316 scpA from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 994764 19746910 spyM18_2074 NP_608046.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4317 speA Streptococcus pyogenes MGAS8232 995014 19745506 spyM18_0393 NP_606642.1 exotoxin type A precursor Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. 2504778 4318 sagA from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 995250 19745828 spyM18_0799 NP_606964.1 streptolysin S associated protein Virulence factor MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. 9529097 4322 SpyM3_0013 Streptococcus pyogenes MGAS315 1008327 21909549 SpyM3_0013 NP_663817.1 putative amino acid permease Virulence factor MUTATION: SpyM3_0013 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. COG0531E, under E: Amino acid transport and metabolism 19223485 4323 SpyM3_0104 Streptococcus pyogenes MGAS315 1008418 21909640 SpyM3_0104 AE014074 NP_663908 protein F2 like fibronectin-binding protein Virulence factor MUTATION: F2 like fibronectin-binding protein mutant had attenuated attachment to to HEp-2 epithelial cells [Ref6955:Kreikemeyer et al., 2004]. COG4932M, under M: Cell wall/membrane/envelope biogenesis 14749329 4324 slo Streptococcus pyogenes MGAS315 1008444 21909666 SpyM3_0130 NP_663934.1 streptolysin O Virulence factor MUTATION: slo mutant was attenuated in mice [Ref6956:Limbago et al., 2000]. 11035749 4325 atmB Streptococcus pyogenes MGAS315 1008547 21909769 SpyM3_0233 NP_664037.1 ABC transporter substrate-binding protein Virulence factor MUTATION: atmB mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. COG1464P, under P: Inorganic ion transport and metabolism 19223485 4326 SpyM3_0385 Streptococcus pyogenes MGAS315 1008699 21909921 SpyM3_0385 AE014074 NP_664189 UDP-glucose 6-dehydrogenase Virulence factor MUTATION: SpyM3_0385 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. COG1004M, under M: Cell wall/membrane/envelope biogenesis 19223485 4327 SpyM3_0386 Streptococcus pyogenes MGAS315 1008700 21909922 SpyM3_0386 AE014074 NP_664190 putative efflux protein Virulence factor MUTATION: SpyM3_0386 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. 19223485 4328 lsp from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1008870 21910092 SpyM3_0556 NP_664360.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4329 salT Streptococcus pyogenes MGAS315 1009964 21911185 SpyM3_1649 NP_665453.1 putative salivaricin A modification enzyme Virulence factor MUTATION: salT mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. COG2274V, under V: Defense mechanisms 19223485 4330 scpA from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010041 21911262 SpyM3_1726 NP_665530.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4331 emm3 Streptococcus pyogenes MGAS315 1010042 21911263 SpyM3_1727 NP_665531.1 antiphagocytic M protein, type 3 Virulence factor MUTATION: emm3 mutant has reduced adherence to and internalization into HEp-2 cells compared to the wild type [Ref6957:Eyal et al., 2003]. COG1196D, under D: Cell cycle control, cell division, chromosome partitioning 14522456 4332 mga from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010043 21911264 SpyM3_1728 NP_665532.1 M protein trans-acting positive regulator, multi-gene activator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4333 speB from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010057 21911278 SpyM3_1742 NP_665546.1 pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. 18796357 4334 SpyM3_1795 Streptococcus pyogenes MGAS315 1010110 21911331 SpyM3_1795 AE014074 NP_665599 hypothetical protein Virulence factor MUTATION: SpyM3_1795 mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. 19223485 4335 hasA Streptococcus pyogenes MGAS315 1010166 21911387 SpyM3_1851 NP_665655.1 hyaluronan synthase Virulence factor MUTATION: hasA mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. COG1215M, under M: Cell wall/membrane/envelope biogenesis 19223485 4348 SPs0560 Streptococcus pyogenes SSI-1 1065796 28895472 SPs0560 NP_801822.1 SpeA precursor Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. 2504778 4349 M6_Spy0741 Streptococcus pyogenes MGAS10394 2941480 50914087 M6_Spy0741 YP_060059.1 SpeA variant Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits [Ref6953:Lee and Schlievert, 1989]. 2504778 4350 speJ from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3573258 71903011 M28_Spy0345 YP_279814.1 exotoxin type J precursor Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. 11179302 4351 scpA from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574429 71904362 M28_Spy1700 YP_281165.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4352 mga from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574433 71904366 M28_Spy1704 YP_281169.1 M protein trans-acting positive regulator (Mga) Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4353 lsp from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574788 71903283 M28_Spy0617 YP_280086.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4354 gidA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571047 71911651 M5005_Spy_1838 YP_283201.1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Virulence factor MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection [Ref6940:Cho and Caparon, 2008]. COG0445D, under D: Cell cycle control, cell division, chromosome partitioning 18426891 4355 speB from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571136 71911548 M5005_Spy_1735 YP_283098.1 streptococcal pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. 18796357 4356 scpA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571155 71911528 M5005_Spy_1715 YP_283078.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4357 mga from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571160 71911533 M5005_Spy_1720 YP_283083.1 trans-acting positive regulator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4358 smeZ Streptococcus pyogenes MGAS5005 3571180 71911515 M5005_Spy_1702 YP_283065.1 mitogenic exotoxin Z Virulence factor MUTATION: smeZ mutant is attenuated in zebrafish [Ref6954:Kizy and Neely, 2009]. 19223485 4359 fba from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571297 71911420 M5005_Spy_1607 YP_282970.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. COG0191G, under G: Carbohydrate transport and metabolism 11679068 4360 M5005_Spy_1305 Streptococcus pyogenes MGAS5005 3571619 71911118 M5005_Spy_1305 YP_282668.1 two-component response regulator Virulence factor MUTATION: In a murine skin infection model, an insertion mutation in the response regulator gene, trxR (M5005_Spy_1305), led to a significant reduction in lesion size, lesion severity, and lethality [Ref6967:Leday et al., 2008]. COG4753T, under T: Signal transduction mechanisms 18678666 4361 grab Streptococcus pyogenes MGAS5005 3571808 71910919 M5005_Spy_1106 YP_282469.1 protein G-related alpha 2M-binding protein Virulence factor MUTATION: grab mutant is attenuated in mice when injected intraperitoneally [Ref6968:Rasmussen et al., 1999]. 10336419 4362 dltA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571853 71910886 M5005_Spy_1073 YP_282436.1 D-alanine--poly(phosphoribitol) ligase subunit 1 Virulence factor MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells [Ref6934:Kristian et al., 2005]. COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 16166534 4363 lsp from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572266 71910450 M5005_Spy_0637 YP_282000.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4364 sagA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572347 71910375 M5005_Spy_0562 YP_281925.1 streptolysin S precursor Virulence factor MUTATION: sagA mutant is attenuated in mice [Ref6932:Betschel et al., 1998]. 9529097 4365 ccpA Streptococcus pyogenes MGAS5005 3572479 71910237 M5005_Spy_0424 YP_281787.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6969:Shelburne et al., 2010]. COG1609K, under K: Transcription 20333240 4366 speJ from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572567 71910169 M5005_Spy_0356 YP_281719.1 exotoxin type J precursor Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS [Ref6931:McCormick et al., 2001]. 11179302 4367 covS Streptococcus pyogenes MGAS5005 3572612 71910097 M5005_Spy_0283 YP_281647.1 transmembrane histidine kinase Virulence factor MUTATION: covS mutant has reduced capacity to bind to epithelial cell layers [Ref6970:Hollands et al., 2010]. COG0642T, under T: Signal transduction mechanisms 20507231 4368 oppA Streptococcus pyogenes MGAS5005 3572677 71910063 M5005_Spy_0249 YP_281613.1 oligopeptide-binding protein Virulence factor MUTATION: oppA mutant caused less mortality and tissue damage than the wild-type strain when inoculated into BALB/c mice via an air pouch [Ref6971:Wang et al., 2005]. COG4166E, under E: Amino acid transport and metabolism 15845494 4369 perR Streptococcus pyogenes MGAS5005 3572745 71909975 M5005_Spy_0161 YP_281525.1 ferric uptake regulation protein Virulence factor MUTATION: perR mutant is attenuated in mouse air sac model [Ref6972:Ricci et al., 2002]. COG0735P, under P: Inorganic ion transport and metabolism 12183543 4389 lsp from Streptococcus pyogenes MGAS9429 Streptococcus pyogenes MGAS9429 4060566 94988323 MGAS9429_Spy0692 YP_596424.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4390 scpA from Streptococcus pyogenes MGAS9429 Streptococcus pyogenes MGAS9429 4061049 94989350 MGAS9429_Spy1720 YP_597451.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4391 scpA from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4063044 94991291 MGAS10270_Spy1782 YP_599391.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4392 lsp from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4063392 94990202 MGAS10270_Spy0693 YP_598302.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4393 fba from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4064175 94991185 MGAS10270_Spy1676 YP_599285.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. COG0191G, under G: Carbohydrate transport and metabolism 11679068 4394 scpA from Streptococcus pyogenes MGAS2096 Streptococcus pyogenes MGAS2096 4064563 94993241 MGAS2096_Spy1744 YP_601340.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4395 lsp from Streptococcus pyogenes MGAS2096 Streptococcus pyogenes MGAS2096 4065311 94992200 MGAS2096_Spy0703 YP_600299.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4396 fba from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4066760 94995059 MGAS10750_Spy1663 YP_603157.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. COG0191G, under G: Carbohydrate transport and metabolism 11679068 4397 scpA from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4066822 94995203 MGAS10750_Spy1807 YP_603301.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4398 lsp from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4067861 94994122 MGAS10750_Spy0726 YP_602220.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4429 lsp from Streptococcus pyogenes str. Manfredo Streptococcus pyogenes str. Manfredo 4963525 139473996 SpyM51170 YP_001128712.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4430 scpA from Streptococcus pyogenes str. Manfredo Streptococcus pyogenes str. Manfredo 4964259 139474482 SpyM51681 YP_001129198.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4438 fba from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985084 209560042 Spy49_1559c YP_002286514.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection [Ref6943:Terao et al., 2001]. COG0191G, under G: Carbohydrate transport and metabolism 11679068 4439 ska Streptococcus pyogenes NZ131 6985239 209560110 Spy49_1630 YP_002286582.1 Streptokinase Virulence factor MUTATION: ska mutant was attenuated in mouse acute poststreptococcal glomerulonephritis model [Ref6988:Nordstrand et al., 2000]. 10678902 4440 scpA from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985276 209560146 Spy49_1669c YP_002286618.1 C5a peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model [Ref6935:Husmann et al., 1997]. COG1404O, under O: Posttranslational modification, protein turnover, chaperones 9119483 4441 mga from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985280 209560150 Spy49_1673c YP_002286622.1 M protein trans-acting positive regulator (Mga) Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection [Ref6938:Luo et al., 2008]. 18588968 4442 speB from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985296 209560166 Spy49_1690c YP_002286638.1 Strepotococcal cysteine protease (Streptopain) / Streptococcal pyrogenic exotoxin B (SpeB) Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains [Ref6939:Chiang-Ni and Wu, 2008]. 18796357 4443 sagA from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985582 209559117 Spy49_0568 YP_002285589.1 Streptolysin S associated protein (SagA) Virulence factor MUTATION: sagA mutant is attenuated in mice [Ref6989:Eberhard et al., 2001]. 11801184 4444 lsp from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985658 209559191 Spy49_0647 YP_002285663.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection [Ref6933:Weston et al., 2009]. COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19398546 4882 hyaluronic acid capsule Streptococcus pyogenes Virulence factor MUTATION: A mutant acapsular strain TX72 (with a mutation in hasA) was avirulent in mice and sensitive to phagocytic killing in vitro [Ref7307:Wessels et al., 1994]. 8300204