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scpA from Streptococcus pyogenes MGAS10750

Victor ID 4397
Gene Name scpA from Streptococcus pyogenes MGAS10750
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10750
NCBI Gene ID 4066822
NCBI Protein GI 94995203
Locus Tag MGAS10750_Spy1807
Protein Accession YP_603301.1
Other Database IDs UniProtKB-ID: Q1J4H9_STRPF
UniRef100: UniRef100_Q1J4H9
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI0000D758BE
EMBL: CP000262
EMBL-CDS: ABF38757.1
RefSeq_NT: NC_008024.1
EnsemblGenome: EBSTRG00000041370.
EnsemblGenome_TRS: EBSTRT00000041374
EnsemblGenome_PRO: EBSTRP00000039769
GenomeReviews: CP000262_GR
KEGG: spi:MGAS10750_Spy1807
eggNOG: COG1404
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO370554:MGAS10750_SPY1807-MONOMER
Taxonomy ID 370554
Gene Starting Position 1761785
Gene Ending Position 1765282
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|94993396:1761785-1765282 Streptococcus pyogenes MGAS10750 chromosome, complete genome
ACTAATCTTCAGTGCGTTTTGTTTTAAAGATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAA
CTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTTTTGTTGATGCTTTT
GTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAGGAGTTTTAC
CTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTGACCTGAACC
GTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGTTTGACCTGAACCGTCTTGTTCTGGTTTAGTT
TCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCTGGCTTATTAGAGTGGCCCTCCAATAGCT
TAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAACAACATAAGTAAAGTCTGACATTTTCAA
CGGAACAGTAGCACCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCATCTTCATTTGGAGAA
ATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGTGTAAGCAATACGCTCACGGTAAATCGGTTGGC
TGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCCGATGTTGCGACTTC
AGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTGAGCTAATCGGAGTG
TAGCGAACACGATAGGTGTATGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTTACCGTCCCAACGCG
TTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTAACAACTTGCTCGGT
TACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGTTTTTAGCATTACGC
AAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGATCGCAGCATATGGCT
TGCCATTAGCGTGACGGTGGATATAGTAGTGACTATCATCGTCTTGTTTTGCAAAAGTACCTGCAAAAAT
GGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGACAGCTTTAATAATC
GTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAACTGTAATCCGTCAC
CATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCTTTGCTATCATAGAT
TGGTTTTTCTAAGGTTGACAGATTGCCAAAATCACCTCGGAAACCAATATATGGAATGCTCATAAGCTCT
TCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTTCATTTGGGCAAGCA
AGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTGGCTGGAATTGTGAT
TTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGCAAAGTGTTTTCCATCTACTTTATCTGTT
TGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACTGTTACTGTTACTTCAA
ATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTGTCCTTATCTGTCACATACATCGTTGC
TGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAATAAGCTTTTTCATCT
TCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACGCTCTGATGGTGTCA
TATCAGGATACTGTGTCTCATATTGCTTTTGCAACAGTCCCATGATACCCGCTACCAATGGCGCAGACAT
ACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGATGACAAAATATCTTGGCCGGGTGCTGCA
ATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAGTTTGGTGCCACTTG
CTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTTAGAATTGTCTTTTAATAAGAGACC
GTCTTTTCGACTGATAAAGGCCGCAGGCATCTGGTCAACATTCGGCAATTCAATCGGGAAGCCCTTGTCC
TGATTGTCATAGATCAAGACTCCTACAGCACCAGCTTTTTTAGCGTTTGCAATCTTATCTTTGAAATCAA
TATCGCCACGTTCAATAAGGGCAATCTTACCTTTGACATCCTTAAAATCATCTTCTTTCATCCCACGATT
AGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAGGCATTTCTTTATCT
TGCTTATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTAAGAAGCAACTGTCA
ATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCTAGAGGTAGACGGGT
CTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAATGCTAACACCTTTTGATTTGGCATAATCA
AAGGCTTTTTTAGTTTCGTCTGGAAGGTTGGCGTAAGCTAGTGCAGCATTACCAAAGCTCATATTAATCA
CCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGAGCGTAGTTACGAGCATAGTCTGCTAGTCCATT
TACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGCGGTAAGGTTCTTTC
GTTTCAGATGGAGCATTTCCTGACAAGATCCCTGACACGTGTGTGCCGTGCTCTTGATCGACAGCGGTTT
TACCATCTTTACTATAGTCGTGGTAATAAGCAACCTTATCATTGACCCACTCACCATAGGTAATACCGTG
ATCTTTTTTGGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTAGATTTGTCTGTTAAGCGCCAC
GCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCCCTTGCCTGCTTTTT
CCTGCAGGGTTTTGACATGAGAAGGGTCGTTCAAATCCCTAATAGTCTCTTTTGAGGTTGCTGGTATATC
AGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCCTTATCTGCTACTGTTTCTTCTGCGTCATCA
GGAGTTTGTGGGGGGTTAGTTTCCTTTGATGATGATGGTGCTTCCTCAGAAACCGCTGTTTGTTGTGGGG
CTTCTACGGCTTGCTCGGTAGCAGGAGTGTCTTCTGTCACAGTATTTGCTTTAATGTCTGATTGTGCATT
GAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTTTATCAAATGGTAGTTTTTGTTTTTTACGCA
Protein Sequence 
>gi|94995203|ref|YP_603301.1| C5A peptidase precursor [Streptococcus pyogenes MGAS10750] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVEAPQQTAVSEEAPSSSKETNPPQTPDDAEETVADKANDLAPQAPAKTADIPATSKETIRDLNDPSHVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKSKARYQSKEDLEKAKKDHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADKQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNSKKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSTLEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPIYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSGQTPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTKDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRTED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].