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gidA from Streptococcus pyogenes M1 GAS

Victor ID 4282
Gene Name gidA from Streptococcus pyogenes M1 GAS
Sequence Strain (Species/Organism) Streptococcus pyogenes M1 GAS
NCBI Gene ID 901831
NCBI Protein GI 15675920
Locus Tag SPy_2185
Protein Accession NP_270094.1
Other Database IDs UniProtKB-ID: MNMG_STRP1
UniRef100: UniRef100_Q99XI8
UniRef90: UniRef90_Q1J990
UniRef50: UniRef50_A8YTQ6
UniParc: UPI000012B454
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34815.1
EMBL-CDS: AAZ52456.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000000305
EnsemblGenome_TRS: EBSTRT00000000305
EnsemblGenome_PRO: EBSTRP00000000305
EnsemblGenome: EBSTRG00000028172
EnsemblGenome_TRS: EBSTRT00000028172
EnsemblGenome_PRO: EBSTRP00000027190
GenomeReviews: AE004092_GR
GenomeReviews
Taxonomy ID 160490
Gene Starting Position 1818086
Gene Ending Position 1819984
Gene Strand (Orientation) -
Protein Name tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
DNA Sequence 
>gi|15674250:1818086-1819984 Streptococcus pyogenes M1 GAS chromosome, complete genome
TTTAATATTTTCGATGAGCTTTTCCGTTTCCTTCTAAATAAATCATCAAGATACTGATGTCCGCAGGATT
GACTCCTGAAATACGACTAGCTTGTCCAATTGTTTCAGGATTAATTTTCTTAAATTTCTGACGCGCCTCA
GTTGCAATAGAATCAATAGCATCCCAATCAATATTTGTAGGAATACGTTTTTCTTCCATGCGTTTCATCT
TAGCAACCTGATCTAAAGCTTTGCGAATATAGCCTTCGTACTTGATTTCTGTTTCTAAAAGTTCAATGAT
TTTAGCATCTAAATCTTCAGCCGCAGGACCAACAAAAGAGACTGCAGTCGCATAATCAATTTCTGGACGA
CGCATGAATTCTTTAGCAGTCATCGCATCGGTTAACGGTTTGAAGCCTAGATCTTGAACGCGGTCATTGG
TTTCTTTAATCGGTTTTAATTTGATACTGTTCAGACGTTTTAATTCGTTATCAAATTGGTTTTTCTTAAT
TTCGAAGGCCTTCCAACGCTCATCATCAACCAACCCAATGTCGCGACCAATCTCTGTCAAACGCATATCA
GCGTTGTCATGACGTAAAATCAAACGATACTCAGCTCGCGATGTCAACAATCGATAAGGTTCCAAGGTTC
CTTTGGTAACCAAATCGTCAATCATAACGCCAATATAGGCATCGCTCCGTTTCAAAATAAGTTCTGGCTT
ACCTTGAACTTTCAAAGCAGCATTGATTCCAGCAATAAGTCCTTGGCCAGCAGCCTCTTCATACCCAGAA
GTTCCATTAGTTTGCCCAGCCGTAAAGAGTCCTGAAATTAGCTTGGTTTCAAGTGTGGCACGTAGCTGGT
GAGGTAAAACAATATCATATTCAATAGCATAACCAGTGCGCATCATTTCAGCCTTTTCAAGTCCTTTGAT
CGAATGAATCAAATCTTTTTGGACATCTTCTGGAAGACTCGTTGACAACCCTTGAACATACACTTCTTCT
GTATCACGCCCCTCTGGCTCTAAGAAAAGTTGATGACGTTCTTTATCAGCAAAGCGAACAATCTTATCTT
CAATAGATGGGCAGTAACGAGGGCCTACACCTTTAACAATGCCAGAAAACATCGGTGCTCTGTAAAGGTT
CTGATTAATGATATCATGACTAGTTTGATTCGTATAAGTCAACCAGCAGGGAATTTGATCTTTGAGATAA
TCAGCATCTTTTGACATAAATGAAAAATGATTAGGTTTGTCATCACCTGGCTGAATTTCCGTTTGATCGT
AATTAATAGAAGATGCTTTGACACGAGGAGGCGTTCCTGTTTTGAATCTGCCAATTTCTAAGCCGAGTTT
TTTTAAATTATCTGCTAAGGTTACTGATGCCAAACTATTATTAGGCCCAGAAGAATATTTGAGTTCTCCT
AAAATAATTTCGCCACGCAGAGCTGTTCCTGTTGTCACTACAACTGCCTTAGCTGCAAATTTTTGTCCTG
TGGCTGTTAAAACACCTACAACTCGTCCATCTTCAACTAGAATATCATCAATCATCGTTTGGCGAAGAGT
CAAATTAGCCTGTTTTTCAACCGTATGTTTCATTTCACGCGCATACAGGGATTTATCTGCTTGAGCTCGG
AGAGCGCGTACAGCTGGTCCCTTACCTGTATTAAGCATTTTCATCTGGATATAAGTTTTATCAATATTTT
TACCCATTTCGCCGCCAAGAGCATCAATCTCTCTAACCACTATCCCTTTGGCAGATCCTCCAATAGAAGG
ATTACACGGCATAAAAGCCAACATATCAAGGTTGATTGTTGCCAATAAAGTTTTACAACCCATACGACTA
GTGGCCAAACTGGCTTCAACACCAGCATGACCTGCACCTATGACAATGACGTCATAGCTTTCTGTAAATT
CATGTGTCA
Protein Sequence 
>gi|15675920|ref|NP_270094.1| tRNA uridine 5-carboxymethylaminomethyl modification protein GidA [Streptococcus pyogenes M1 GAS] MTHEFTESYDVIVIGAGHAGVEASLATSRMGCKTLLATINLDMLAFMPCNPSIGGSAKGIVVREIDALGGEMGKNIDKTYIQMKMLNTGKGPAVRALRAQADKSLYAREMKHTVEKQANLTLRQTMIDDILVEDGRVVGVLTATGQKFAAKAVVVTTGTALRGEIILGELKYSSGPNNSLASVTLADNLKKLGLEIGRFKTGTPPRVKASSINYDQTEIQPGDDKPNHFSFMSKDADYLKDQIPCWLTYTNQTSHDIINQNLYRAPMFSGIVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLIHSIKGLEKAEMMRTGYAIEYDIVLPHQLRATLETKLISGLFTAGQTNGTSGYEEAAGQGLIAGINAALKVQGKPELILKRSDAYIGVMIDDLVTKGTLEPYRLLTSRAEYRLILRHDNADMRLTEIGRDIGLVDDERWKAFEIKKNQFDNELKRLNSIKLKPIKETNDRVQDLGFKPLTDAMTAKEFMRRPEIDYATAVSFVGPAAEDLDAKIIELLETEIKYEGYIRKALDQVAKMKRMEEKRIPTNIDWDAIDSIATEARQKFKKINPETIGQASRISGVNPADISILMIYLEGNGKAHRKY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection (Cho and Caparon, 2008).
COG COG0445D, under D: Cell cycle control, cell division, chromosome partitioning
References
Cho and Caparon, 2008: Cho KH, Caparon MG. tRNA modification by GidA/MnmE is necessary for Streptococcus pyogenes virulence: a new strategy to make live attenuated strains. Infection and immunity. 2008; 76(7); 3176-3186. [PubMed: 18426891].