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fba from Streptococcus pyogenes MGAS10750

Victor ID 4396
Gene Name fba from Streptococcus pyogenes MGAS10750
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS10750
NCBI Gene ID 4066760
NCBI Protein GI 94995059
Locus Tag MGAS10750_Spy1663
Protein Accession YP_603157.1
Other Database IDs UniProtKB-ID: Q1J4X3_STRPF
UniRef100: UniRef100_P68905
UniRef90: UniRef90_P68905
UniRef50: UniRef50_P0A4S2
UniParc: UPI0000165A3F
EMBL: CP000262
EMBL-CDS: ABF38613.1
RefSeq_NT: NC_008024.1
EnsemblGenome: EBSTRG00000041729.
EnsemblGenome_TRS: EBSTRT00000041734
EnsemblGenome_PRO: EBSTRP00000040129
GenomeReviews: CP000262_GR
KEGG: spi:MGAS10750_Spy1663
eggNOG: COG0191
HOGENOM: HBG327581
OMA: EYEANEA
ProtClustDB: PRK07315
BioCyc: SPYO370554:MGAS10750_SPY1663-MONOMER
Taxonomy ID 370554
Gene Starting Position 1598694
Gene Ending Position 1599575
Gene Strand (Orientation) -
Protein Name fructose-bisphosphate aldolase
DNA Sequence 
>gi|94993396:1598694-1599575 Streptococcus pyogenes MGAS10750 chromosome, complete genome
ATTATGCTTTGTTAGCTGATCCGAAAACATCGATACGTTCTTCAACAGCACCTTGAACAGCTTTCATACC
TGGAGCCAAGAATTTACGTGGGTCAAATAATTTTTTACCATCATATTCTGCTTCGTTAGCTTCGTAGTTA
CGAGCAAATTCACGAGTTGCGTTAGAGAAAGCGATTTGACTTTCAGTGTTAACGTTAACTTTAGCAACAC
CAAGACGGATTGCTTCTTTGATTTGATCGTCAGGAATACCAGAACCACCGTGCAATACGATTGGGAAACC
TGGTACAGCTGCTGTTAATTTTTCTAAGTGGTCAAGAGCAAGACCTTCCCAGTTTTCTGGGTATGGACCG
TGGATGTTACCGATACCAGCTGCCAAGAAGTCAATTCCGGTTTCAACCATTGCTTTAGCATCTTCGATTG
GAGCGAGCTCACCTTTACCGATGATACCGTCTTCTTCACCACCGATTGTACCAACTTCAGCTTCAACTGA
AACGCCTTTAGCATGTGCAATTTTAACAACTTCTGCAGTTTTAGCAAGGTTTTCTTCAACTGGAAGGTGT
GAACCGTCAAACATGATTGAAGTGTAACCTACTTCGATACACTCAAGAGCATCTTCGTAGTGACCATGAT
CAAGGTGGATAGCAACAGGAACAGTGATACCCATTGACTCAACAAGGTTAGTAATAAGAGATTGACATAC
TTTATAACCACCCATGTATTTTGCTGCACCCATTGATGTTTGGATAAGAACTGGAGCTTGTTTAGCTTCT
GCTGCACGCAATATTGCTTGAGTCCACTCTAAGTTGTTTGTGTTAAATCCACCAACAGCATATCCGTTTT
CACGAGCTGCTTGGACAAATTTTTCTGCTGAAACGATTGCCA
Protein Sequence 
>gi|94995059|ref|YP_603157.1| fructose-bisphosphate aldolase [Streptococcus pyogenes MGAS10750] MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFSNATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001).
COG COG0191G, under G: Carbohydrate transport and metabolism
References
Terao et al., 2001: Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Molecular microbiology. 2001; 42(1); 75-86. [PubMed: 11679068].