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covS

Victor ID 4367
Gene Name covS
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3572612
NCBI Protein GI 71910097
Locus Tag M5005_Spy_0283
Protein Accession YP_281647.1
Other Database IDs UniProtKB-ID: Q490R6_STRP1
UniRef100: UniRef100_Q490R6
UniRef90: UniRef90_Q1JDF5
UniRef50: UniRef50_B5XJV6
UniParc: UPI000057CD64
EMBL: CP000017
EMBL-CDS: AAZ50902.1
RefSeq_NT: NC_007297.1
EnsemblGenome: EBSTRG00000027483.
EnsemblGenome_TRS: EBSTRT00000027483
EnsemblGenome_PRO: EBSTRP00000026501
GenomeReviews: CP000017_GR
KEGG: spz:M5005_Spy_0283
HOGENOM: HBG694527
OMA: AKWITER
ProtClustDB: CLSK698300
BioCyc: SPYO293653:M5005_SPY0283-MONOMER
Taxonomy ID 293653
Gene Starting Position 293258
Gene Ending Position 294622
Gene Strand (Orientation) +
Protein Name transmembrane histidine kinase
DNA Sequence 
>gi|71909814:293258-294622 Streptococcus pyogenes MGAS5005 chromosome, complete genome
ATTGAAGAAAGAAAAGCAGTCAGTCTTTCAAGCTGTAAATATTGTTAGAGTTCGTCTTTCTGAGGTGGAC
TCTAATTTTACATTAGAGAACTTAGCAGAAGTTTTGTACAAAAACGATAAAACACATCTGAGAATTGATG
ACAGAAAGGGCAGTCGAGTCATTAGGAGTGAGCGCGATATCACAAATACTCTAGATGCGAATCAAGATAT
TTATGTCTATAACATTGATAAACAGATGATTTTTACCACAGATAACGAAGAATCATCTCCTGGCTTGCAT
GGTCCTATCGGTCGTGTGTATCACGACCATATCGAAGATCAGTATCGTGGGTTTTCCATGACACAAAAGG
TATATTCTAATCGGACTGGAAAATTTGTGGGCTATGTTCAAGTCTTTCATGATTTAGGCAATTATTATGT
CATTAGAGCAAGACTGCTGTTTTGGCTACTAGTTGTTGAGTTATTTGGCACAAGCTTAGCCTATTTAATC
ATCTTAATTACTACGCGGCGCTTTTTGAAGCCTTTACACAATTTACATGAAGTGATGCGTAATATCTCTG
AAAATCCTAATAATTTAAACCTGCGCTCAGATATTTCGTCAGGAGATGAAATCGAAGAATTGTCTGTTAT
CTTTGACAATATGTTAGACAAATTGGAGACACATACTAAGTTGCAATCACGTTTTATTAGTGATGTCAGC
CATGAATTACGAACACCGGTTGCGATTATTAAAGGGCATATTGGTCTCTTACAACGTTGGGGTAAAGATG
ACAGTGATATTCTTGAAGAAAGCTTGACAGCAACAGCGCATGAGGCTGACCGTATGGCAATCATGATTAA
TGATATGTTAGACATGGTTCGCGTACAAGGCTCATTTGAGGGACATCAAAATGATATGACAGTTTTGGAA
GATTCTATTGAAACTGTTGTTGGTAATTTTAGAGTTTTAAGAGAAGATTTTATCTTTACATGGCAGTCAG
AAAATCCAAAAACGATAGCCCGTATTTATAAAAATCATTTTGAGCAGGCTTTGATGATTCTGATTGACAA
TGCTGTGAAGTATTCCCGTAAAGAAAAGAAAATCGCGATTAACCTTTCAGTGACTGGCAAACAAGAAGCT
ATTGTTAGAGTTCAAGATAAAGGCGAAGGAATTTCTAAAGAAGATATTGAACATATCTTTGAACGCTTTT
ATAGAACGGATAAATCACGTAATCGAACAAGTACCCAGGCTGGATTAGGGATTGGCTTGTCTATTCTCAA
GCAAATTGTAGATGGGTATCATTTACAGATGAAGGTTGAAAGTGAATTAAATGAAGGTTCAGTGTTTATC
TTACATATTCCTTTGGCCCAGTCTAAAGAGAGTTA
Protein Sequence 
>gi|71910097|ref|YP_281647.1| transmembrane histidine kinase [Streptococcus pyogenes MGAS5005] MKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMTQKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNLRSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWGKDDSDILEESLTATAHEADRMAIMINDMLDMVRVQGSFEGHQNDMTVLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKYSRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVESELNEGSVFILHIPLAQSKES
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: covS mutant has reduced capacity to bind to epithelial cell layers (Hollands et al., 2010).
COG COG0642T, under T: Signal transduction mechanisms
References
Hollands et al., 2010: Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V. Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone. The Journal of infectious diseases. 2010; 202(1); 11-19. [PubMed: 20507231].