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lsp from Streptococcus pyogenes MGAS9429

Victor ID 4389
Gene Name lsp from Streptococcus pyogenes MGAS9429
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS9429
NCBI Gene ID 4060566
NCBI Protein GI 94988323
Locus Tag MGAS9429_Spy0692
Protein Accession YP_596424.1
Other Database IDs UniProtKB-ID: LSPA_STRPC
UniRef100: UniRef100_Q1JCF3
UniRef90: UniRef90_Q1JCF3
UniRef50: UniRef50_Q5M0X5
UniParc: UPI000000AF69
EMBL: CP000259
EMBL-CDS: ABF31880.1
RefSeq_NT: NC_008021.1
EnsemblGenome: EBSTRG00000045968
EnsemblGenome_TRS: EBSTRT00000045976
EnsemblGenome_PRO: EBSTRP00000044193
GenomeReviews: CP000259_GR
KEGG: spk:MGAS9429_Spy0692
eggNOG: COG0597
HOGENOM: HBG724422
OMA: ADSSGWQ
ProtClustDB: PRK14797
BioCyc: SPYO370551:MGAS9429_SPY0692-MONOMER
Taxonomy ID 370551
Gene Starting Position 677199
Gene Ending Position 677657
Gene Strand (Orientation) +
Protein Name lipoprotein signal peptidase
DNA Sequence 
>gi|94987631:677199-677657 Streptococcus pyogenes MGAS9429 chromosome, complete genome
CATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGG
ATTGTTTCTCATATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGC
AAAACAATGGGGCTGCCTTTTCCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGT
TATCGGTTATGCTATTTATTACCTTGCTACTCATCCCCATTTAAATATCTGGAAGCAATTAGCTCTCTTG
CTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTTGCGTTTAGCTTACGTGATTGATATGGTTC
ATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTACCGTTGGTGTCATATTGTT
AGTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTA
Protein Sequence 
>gi|94988323|ref|YP_596424.1| lipoprotein signal peptidase [Streptococcus pyogenes MGAS9429] MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009).
COG COG0597MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weston et al., 2009: Weston BF, Brenot A, Caparon MG. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity. 2009; 77(7); 2840-2848. [PubMed: 19398546].