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scpA from Streptococcus pyogenes MGAS6180

Victor ID 4351
Gene Name scpA from Streptococcus pyogenes MGAS6180
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS6180
NCBI Gene ID 3574429
NCBI Protein GI 71904362
Locus Tag M28_Spy1700
Protein Accession YP_281165.1
Other Database IDs UniProtKB-ID: Q48R50_STRPM
UniRef100: UniRef100_Q48R50
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI000057BF78
EMBL: CP000056
EMBL-CDS: AAX72810.1
RefSeq_NT: NC_007296.1
EnsemblGenome: EBSTRG00000032167.
EnsemblGenome_TRS: EBSTRT00000032167
EnsemblGenome_PRO: EBSTRP00000030999
GenomeReviews: CP000056_GR
KEGG: spb:M28_Spy1700
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SPYO319701:M28_SPY1700-MONOMER
Taxonomy ID 319701
Gene Starting Position 1705825
Gene Ending Position 1709424
Gene Strand (Orientation) -
Protein Name C5A peptidase precursor
DNA Sequence 
>gi|71902667:1705825-1709424 Streptococcus pyogenes MGAS6180 chromosome, complete genome
ACTAATCTTCAGTGCGTTTTGTTTTAAAGATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAA
CTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTTGATGCTTTT
GTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGCACGAGAAGGTTGACCTTTTTGAGGAGTTTTAC
CTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGGTTTTTTATTTGGTGTTTGACCTGAACC
GTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGACCTGAACCGTCTTGTTCTGGTTTAGCT
TCTGGTTTTTTGTCTGGTGCTTGACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTG
CTTGACCTGAACCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCATCTTG
TTCTGGCTTATTAGAGTGACCCTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCT
TCAACAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTACCGCCTTCCATTGTTTCAGCCTCTTCAG
GAAGAGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATAAGT
GTAAGCAATACGCTCACGGTAAATCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCT
TCTGTTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGT
GTTGTTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGAACACGATAGGTGTAGGTTCCGTTAGCAACAAC
TTTGCCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAG
TCATTGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCA
AGACTTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACC
GTCCCCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCA
TCGTCTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGT
TTTCAACCCCTTCTTTGACAGCTTTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTT
GTTTTTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGA
TAGTAGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTC
GGAAACCAATATATGGAATGCTCATAAGCTCTTCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTC
TAAGAAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTG
ACTTGTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCA
AGGCAAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATC
AGATTTGTTGTGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAG
GTATTATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTT
GTTGGCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTT
TTTAGCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAATAGT
CCCATGATACCCGCTACCAATGGCGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCA
CTGACGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACCCCA
GCTTGAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATG
GTTTTTTGGGGATTGTCTTTTAATAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAA
CATTTGGCAATTCAATCGGGAAGCCCTTGTCCTGATTGTCATAGATCAAGACCCCTACAGCACCAGCTTT
TTTAGCGTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTACCTTCGACA
TCCTTAAAATCATCCTCTTTCGTACCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAAC
GGTTTGTTGAAAGAACAGGCATTTCTTTATCTTGATGATCGTCTGTTTTGACCGTAGCAGTTTCAGTGAG
CTGTTTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAATCTGCCGCTGCAGGTGTCCCAACCACCCCA
TAATCAGGATGATCTGCTAGAGGTAGACGGGTTTTGCCCCCAAAACTACTATCATTACCAGCTGAGGTCA
CAATGCTAACACCTTTTGATTTGGCATAATCAAAAGCTTTTTTGGTTTCGTCTGGAAGGTTGGCGTAAGC
TAGTGCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCTTGA
GCGTAGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAG
GCATCGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTCCCTGACAAGATCCCTGACAC
GTGTGTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTGCTATAGTCGTGGTAATAAGCAACCTTA
TCATTGACCCACTCGCCGTAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGT
AACGTGCTTTGGTTTTGTCTGTTAAACGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGC
AACAACAGTCCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCC
CTAATAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTGGATCATTAG
CCTTATCTGCTACTGTTTCTTCTGCGTCATCAGGAATTTGTGGAGGGTTAGTTTCCTTTGATGATGATGG
TGCTTCCTCAGAAACCGCTGTTGGTTGTGGGGGTTCTACGGCTTGTTCGGTAGCAGGAGTGTCTTCTGTC
ACAGTATTTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTT
TATCAAATGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|71904362|ref|YP_281165.1| C5A peptidase precursor [Streptococcus pyogenes MGAS6180] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVEPPQPTAVSEEAPSSSKETNPPQIPDDAEETVADKANDPAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTDDHQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVEGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPIYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGGTVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSGQAPDKKPEAKPEQDGSGQAPDKKPEAKPEQDGSGQAPDKKPEAKPEQDGSGQTPNKKPETKPEKDSSGQTPGKTPQKGQPSRALEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRTED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].