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fba from Streptococcus pyogenes NZ131

Victor ID 4438
Gene Name fba from Streptococcus pyogenes NZ131
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985084
NCBI Protein GI 209560042
Locus Tag Spy49_1559c
Protein Accession YP_002286514.1
Other Database IDs UniProtKB-ID: B5XIF7_STRPZ
UniRef100: UniRef100_P68905
UniRef90: UniRef90_P68905
UniRef50: UniRef50_P0A4S2
UniParc: UPI0000165A3F
EMBL: CP000829
EMBL-CDS: ACI61819.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000049131.
EnsemblGenome_TRS: EBSTRT00000049139
EnsemblGenome_PRO: EBSTRP00000059682
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_1559c
HOGENOM: HBG327581
OMA: EYEANEA
ProtClustDB: PRK07315
Taxonomy ID 471876
Gene Starting Position 1531688
Gene Ending Position 1532569
Gene Strand (Orientation) -
Protein Name fructose-bisphosphate aldolase
DNA Sequence 
>gi|209558587:1531688-1532569 Streptococcus pyogenes NZ131 chromosome, complete genome
ATTATGCTTTGTTAGCTGATCCGAAAACATCGATACGTTCTTCAACAGCACCTTGAACAGCTTTCATACC
TGGAGCCAAGAATTTACGTGGGTCAAATAATTTTTTACCATCATATTCTGCTTCGTTAGCTTCGTAGTTA
CGAGCAAATTCACGAGTTGCGTTAGAGAAAGCGATTTGACTTTCAGTGTTAACATTAACTTTAGCAACAC
CAAGACGGATTGCTTCTTTGATTTGATCGTCAGGAATACCAGAACCACCGTGCAATACGATTGGGAAACC
TGGTACAGCTGCTGTTAATTTTTCTAAGTGGTCAAGAGCAAGACCTTCCCAGTTTTCTGGGTATGGACCG
TGGATGTTACCGATACCAGCTGCCAAGAAGTCAATTCCAGTTTCAACCATTGCTTTAGCATCTTCGATTG
GAGCGAGCTCACCTTTACCGATGATACCGTCTTCTTCACCACCGATTGTACCAACTTCAGCTTCAACTGA
AACGCCTTTAGCATGTGCAATTTTAACAACTTCTGCAGTTTTAGCAAGGTTTTCTTCAACTGGAAGGTGT
GAACCGTCAAACATGATTGAAGTGTAACCTACTTCGATACACTCAAGAGCATCTTCGTAGTGACCATGAT
CAAGGTGGATAGCAACAGGAACAGTGATACCCATTGACTCAACAAGGTTAGTAATAAGAGATTGACATAC
TTTATAACCACCCATGTATTTTGCTGCACCCATTGATGTTTGGATAAGAACTGGAGCTTGTTTAGCTTCT
GCTGCACGCAAGATTGCTTGAGTCCACTCTAAGTTGTTTGTGTTAAATCCACCAACAGCATATCCGTTTT
CACGAGCTGCTTGGACAAATTTTTCTGCTGAAACGATTGCCA
Protein Sequence 
>gi|209560042|ref|YP_002286514.1| fructose-bisphosphate aldolase [Streptococcus pyogenes NZ131] MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFSNATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001).
COG COG0191G, under G: Carbohydrate transport and metabolism
References
Terao et al., 2001: Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Molecular microbiology. 2001; 42(1); 75-86. [PubMed: 11679068].