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SpyM3_0385

Victor ID 4326
Gene Name SpyM3_0385
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS315
NCBI Gene ID 1008699
NCBI Protein GI 21909921
Locus Tag SpyM3_0385
Genbank Accession AE014074
Protein Accession NP_664189
Other Database IDs UniProtKB-ID: Q8K8A7_STRP3
UniRef100: UniRef100_Q8K8A7
UniRef90: UniRef90_B5XKC8
UniRef50: UniRef50_Q1J7U2
UniParc: UPI000000B013
EMBL: AE014074
EMBL: BA000034
EMBL-CDS: AAM78992.1
EMBL-CDS: BAC64563.1
RefSeq_NT: NC_004070.1
RefSeq_NT: NC_004606.1
HSSP: Q07172
EnsemblGenome: EBSTRG00000034166.
EnsemblGenome_TRS: EBSTRT00000034166
EnsemblGenome_PRO: EBSTRP00000032905
EnsemblGenome: EBSTRG00000036358.
EnsemblGenome_TRS: EBSTRT00000036358
EnsemblGenome_PRO: EBSTRP00000035008
GenomeReviews: AE014074
Taxonomy ID 198466
Gene Starting Position 429670
Gene Ending Position 430827
Gene Strand (Orientation) +
Protein Name UDP-glucose 6-dehydrogenase
Protein pI 8.62
Protein Weight 41998.03
Protein Length 385
Protein Note best non-GAS blastp hit: dbj|BAB07427.1| (AP001519) nucleotide sugar dehydrogenase [Bacillus halodurans]
DNA Sequence 
>gi|21909536:429670-430827 Streptococcus pyogenes MGAS315 chromosome, complete genome
CATGAAAATTACAGTTGTAGGCATTGGATACGTTGGATTATCGATAGGGCTCCTACTTGCAAAGGAACAC
GACGTTACCTTTTTTGATATTGATAATAAAAAAATTGATTTAATAAATAAAAGGCAATCCCCTCTTAAAG
AAGCAGCTATAAACAAACTTTTATGTAAGGCAAAAAATATTAATGCAACTTATTCTGAAGAATTAGCATA
TAAGGATGCGACTTTCATAATCTTGTCTTTGCCAACCAACCTAAAAGTTAATAAGCTTGATACTTCCATT
ATCGAAATTTCTGTAAGTAATATTTTAAAGATAAACAAAAAGGCTACAATTGTAATAAAGTCGACAGTTC
CAATTGGTTTTACAGAATATTTAAGGAATCGATTTCACTACAACGATATCATTTTTTCACCTGAGTTCCT
TAGGGAAGGATCAACTATTTATGATCAATTGTATCCTTCGAGAACTATAGTTGGAAATGAATCTAGAAAT
TCTCAATTATTCTTAGACATACTAACAGATATATCGGTTGAAAAAGACTCGTCATCTTTATTAGTTGGCT
CTTCTGAAGCAGAAGCGATAAAGTTATTTTCGAATGCATACTTGGCACAAAAAATTGCTTTTTTTAATGA
GTTGGATACGTTTGCTGAAATGCAAAATTTGGACTCAAAAAAAATTATTGAGGCTATGGGATATGACCAG
AGAATAGGAAATTCGCACAATAATCCTTCTTTCGGTTTTGGTGGGTACTGTCTTCCTAAGGATATTAAGC
AATTAGAGTATCATTTTAAAGAAATTCCAGCACCAATTATTACCAGTATAAGTGAGTCTAATTTATTAAG
AAAAATTCATATAGCAAAAATGATTTTGAACAGCTCAGCTAAAACAATAGGAATTTATAGAATTAATTCC
AAAAAAGATTCGGATAATTGTAGGGAATCTTCTACAATTGATGTTGCTAAACTTCTAAAAAGCAGTGGTA
AGGATGTTATCATCTTTGAGCCCTTAATTAACCAAAAAAAGTTTTTGGGGTGCCCTTTAATTAATGATTT
TAATGAATTTATTAAATATTCGGATATTATAGTTGCCAATAGAATAGATGATGCTCTGAGAAAATGTAAT
TCAAAAGTTTTTACACGTGATATTTTTCAGTATGATTA
Protein Sequence 
>gi|21909921|ref|NP_664189.1| UDP-glucose 6-dehydrogenase [Streptococcus pyogenes MGAS315]
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATYSEELAY
KDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFL
REGSTIYDQLYPSRTIVGNESRNSQLFLDILTDISVEKDSSSLLVGSSEAEAIKLFSNAYLAQKIAFFNE
LDTFAEMQNLDSKKIIEAMGYDQRIGNSHNNPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLR
KIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDF
NEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SpyM3_0385 mutant is attenuated in zebrafish (Kizy and Neely, 2009).
COG COG1004M, under M: Cell wall/membrane/envelope biogenesis
References
Kizy and Neely, 2009: Kizy AE, Neely MN. First Streptococcus pyogenes signature-tagged mutagenesis screen identifies novel virulence determinants. Infection and immunity. 2009; 77(5); 1854-1865. [PubMed: 19223485].