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scpA from Streptococcus pyogenes NZ131

Victor ID 4440
Gene Name scpA from Streptococcus pyogenes NZ131
Sequence Strain (Species/Organism) Streptococcus pyogenes NZ131
NCBI Gene ID 6985276
NCBI Protein GI 209560146
Locus Tag Spy49_1669c
Protein Accession YP_002286618.1
Other Database IDs UniProtKB-ID: B5XIS4_STRPZ
UniRef100: UniRef100_B5XIS4
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI000181F3DE
EMBL: CP000829
EMBL-CDS: ACI61923.1
RefSeq_NT: NC_011375.1
EnsemblGenome: EBSTRG00000050483.
EnsemblGenome_TRS: EBSTRT00000050491
EnsemblGenome_PRO: EBSTRP00000059455
GenomeReviews: CP000829_GR
KEGG: soz:Spy49_1669c
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
Taxonomy ID 471876
Gene Starting Position 1648660
Gene Ending Position 1652049
Gene Strand (Orientation) -
Protein Name C5a peptidase precursor
DNA Sequence 
>gi|209558587:1648660-1652049 Streptococcus pyogenes NZ131 chromosome, complete genome
CTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTGAGGAGTTTTACCTGGTGTTTGACCTG
AACTATCTTTTCTGGTTTAGTTTCTGGTTTTTTATCTGGTGTTTGACCTGACCCGTCTTGTTCTGGTTTA
GTTTCTGGTTTTTTGTCTGGTGCTTGATCTGACCCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTG
GTGCTTGATCTGAACCGTCTTGTTCTGGTTTAGTTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCATC
TTGTTCTGGCTTATTAGAGTGACCCTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATA
TCTTCAACAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTT
CAGGAAGAGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATATA
AGTGTAAGCAATACGCTCACGGTAAACCGGTTGGCTAGTTTTTGGTTTAGATGCAAGTGTCAAACGACGA
TCTTCTGTTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAG
TGTGTTGTTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAAC
AACTTTGCCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTACTTGCC
AAATCATTGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGT
CCAAGACTTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTT
ACCGTCCCCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTA
TCATCGTCTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTA
TGTTTTCAACTCCTTCTTTGACAGCTTTAATAATCGTCCATGGGTTAGACTCTGTGGTAAGTGCTGTAAA
GTTATTTTTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCA
TGATAGTAGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCAC
CTCGGAAACCAATATATGGAATGCTCATAAGCTCTTCTTTTGTAGGATCTTGTTTGAAACGAACAAAACC
TTCTAAGAAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATTGACTAGCATCGATTGGAATG
GTGACTTGTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAG
CCAAGGCAAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTT
ATCAGATTTGTTGTGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTT
GAGGTATTATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTC
CTTGTTGGCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATAC
TTTTTTAGCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTCATATTGCTTTTGCAAC
AGTCCCATGATACCCGCTACTAATGGCGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAG
CCACTGATGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTGCCGTCAGCTGTCAGACC
CCAGCTTGAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTG
ATGGTTTTTTTAGAATTGTCTTTTAATAAGAGACCGTCTTTTCGACTGATAAAGGCCGCAGGCATTTGGT
CAACATTTGGCAATTCAATCGGGAAGCCCTTGTCTTGATTGTCATAGATCAAGACCCCTACAGCACCAGC
TTTTTTAGCGTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATTTTGCCTTTG
ACATCCTTAAAATCATCTTCTTTCATCCCACGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAA
AACGGTTTGTTGAAAGAACAGGCATTTCTTTATCTTGCTTATCGGCTGTTTTGACCGTAGCAGTTTCAGT
GAGCTGTTTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACC
CCATAATCAGGATGATCTGCTAGAGGTAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGG
TCACAATGCTAACACCTTTTGATTTGGCATAATCAAAAGCTTTTTTGGTTTCGTCTGGAAGGTTGGCGTA
AGCTAGTGCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGACAGCATCTCTGATAGCT
TGAGCGTAGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCT
CAGGCATCGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATCCCTGA
CACGTGTGTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTACTATAGTCGTGGTAGTAAGCAACC
TTATCATTGACCCACTCGCCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATT
GGTAACGTGCTTTGGCTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCAC
TGCAACAACAGTCCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAA
TCCCTAATAGTCGCTTTTGAGGTTGCTGACGTATCAGTAGTTTTAGCAGGAGCTTGAGGGGCTAGATCAT
TAGCGTCATCTGCTACTGTTTCTTCTGCGTCATCAGGAGTTTGTGGAGTTTTGGTTTCCTTTGATGATGG
TACTTCCTCAGAAACCGTTGTTGGTTGTGGGGTTTCTACGGCTTGTTCAGTAGCAGGAGTGTCTTCTGTC
ACAGTATTTGCTTTAATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATGAGCGCAATGGCAAGTT
TATCAAATGGTAATTTTTGTTTTTTACGCA
Protein Sequence 
>gi|209560146|ref|YP_002286618.1| C5a peptidase [Streptococcus pyogenes NZ131] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQAVETPQPTTVSEEVPSSKETKTPQTPDDAEETVADDANDLAPQAPAKTTDTSATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADKQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNSKKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTIPIDASQFSKDLLAQMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPETKPEQDGSDQAPDKKPETKPEQDGSDQAPDKKPETKPEQDGSGQTPDKKPETKPEKIVQVKHQVKLLKRSTFSYSRETIF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Husmann et al., 1997: Husmann LK, Yung DL, Hollingshead SK, Scott JR. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia. Infection and immunity. 1997; 65(4); 1422-1430. [PubMed: 9119483].