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smeZ

Victor ID 4358
Gene Name smeZ
Sequence Strain (Species/Organism) Streptococcus pyogenes MGAS5005
NCBI Gene ID 3571180
NCBI Protein GI 71911515
Locus Tag M5005_Spy_1702
Protein Accession YP_283065.1
Other Database IDs UniProtKB-ID: Q99XW1_STRP1
UniRef100: UniRef100_Q99XW1
UniRef90: UniRef90_Q1JJS8
UniRef50: UniRef50_Q1JJS8
UniParc: UPI00000C7EEF
EMBL: AE004092
EMBL: CP000017
EMBL-CDS: AAK34680.1
EMBL-CDS: AAZ52320.1
RefSeq_NT: NC_002737.1
RefSeq_NT: NC_007297.1
HSSP: Q9RQQ5
EnsemblGenome: EBSTRG00000000057.
EnsemblGenome_TRS: EBSTRT00000000057
EnsemblGenome_PRO: EBSTRP00000000057
EnsemblGenome: EBSTRG00000028261.
EnsemblGenome_TRS: EBSTRT00000028261
EnsemblGenome_PRO: EBSTRP00000027279
GenomeReviews: AE004092
Taxonomy ID 293653
Gene Starting Position 1662279
Gene Ending Position 1662980
Gene Strand (Orientation) +
Protein Name mitogenic exotoxin Z
DNA Sequence 
>gi|71909814:1662279-1662980 Streptococcus pyogenes MGAS5005 chromosome, complete genome
TATGAAAAAAACAAAACTTATTTTTTCTTTTACTTCAATATTCATTGCAATAATTTCTCGTCCTGTGTTT
GGATTAGAAGTAGATAATAATTCCCTTCTAAGGAATATCTATAGTACGATTGTATATGAATATTCAGATA
CAGTAATTGATTTTAAAACCAGTCATAACTTAGTGACTAAGAAACTTGATGTTAGAGATGCTAGAGATTT
TTTTATTAACTCCGAAATGGATGAATATGCAGCCAATGATTTTAAAGATGGAGATAAAATAGCTATGTTC
TCCGTCCCATTTGATTGGAACTACTTGTCAGAAGGAAAAGTCATAGCATATACCTATGGTGGAATGACGC
CTTATCAAGAAGAACCAATGTCTAAAAATATCCCTGTTAATTTATGGATTAATAGAAAGCAGATTCCTGT
CCCCTATAATCAAATATCAACTAACAAAACAACAGTTACAGCTCAAGAAATTGATCTAAAGGTTAGAAAA
TTTTTAATATCACAACATCAATTATATTCTTCTGGTTCTAGCTACAAAAGTGGTAAATTAGTTTTTCATA
CAAATGATAATTCAGATAAATATTCTCTCGATCTTTTCTATGTAGGATATAGAGATAAAGAAAGTATTTT
TAAAGTATACAAAGACAATAAATCTTTCAATATAGATAAAATTGGGCATTTAGATATAGAAATTGACTCC
TA
Protein Sequence 
>gi|71911515|ref|YP_283065.1| mitogenic exotoxin Z [Streptococcus pyogenes MGAS5005] MKKTKLIFSFTSIFIAIISRPVFGLEVDNNSLLRNIYSTIVYEYSDTVIDFKTSHNLVTKKLDVRDARDFFINSEMDEYAANDFKDGDKIAMFSVPFDWNYLSEGKVIAYTYGGMTPYQEEPMSKNIPVNLWINRKQIPVPYNQISTNKTTVTAQEIDLKVRKFLISQHQLYSSGSSYKSGKLVFHTNDNSDKYSLDLFYVGYRDKESIFKVYKDNKSFNIDKIGHLDIEIDS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: smeZ mutant is attenuated in zebrafish (Kizy and Neely, 2009).
References
Kizy and Neely, 2009: Kizy AE, Neely MN. First Streptococcus pyogenes signature-tagged mutagenesis screen identifies novel virulence determinants. Infection and immunity. 2009; 77(5); 1854-1865. [PubMed: 19223485].