| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
ACE2 |
Candida albicans SC5314 |
3645995
|
|
68487492
|
CaO19.13543 |
AACQ01000160 |
XP_712367 |
|
Virulence factor |
MUTATION: ace2 mutant is virulent in a mouse model [Ref7079:Kelly et al., 2004].
|
15255906
|
|
|
ADE2 |
Candida albicans ATCC 32354 |
|
1658378
|
1658379
|
|
|
AAC49755.1 |
phosphoribosylaminoimidazole carboxylase |
Virulence factor |
MUTATION: ade2 mutant is avirulent in immunosuppressed mice [Ref7080:Donovan et al., 2001].
|
11254618
|
|
|
ALO1 |
Candida albicans SC5314 |
3638983
|
|
68473015
|
CaO19.7551 |
AACQ01000032 |
XP_719313 |
|
Virulence factor |
MUTATION: alo1 mutant is attenuated in mice [Ref7081:Huh et al., 2001].
|
11349062
|
|
|
ALS1 |
Candida albicans |
|
|
7687905
|
|
|
|
agglutinin-like protein |
Virulence factor |
MUTATION: als1p mutant is attenuated in mice [Ref7082:Fu et al., 2002].
MUTATION: als1p mutant has attenuated destruction of epithelial destruction in buccal reconstituted human epithelium (RHE) model of oral canididiasis [Ref7083:Zhao et al., 2004].
|
11967069
15256583
|
|
|
ALS3 |
Candida albicans |
|
29373982
|
29373983
|
|
|
AAO72959.1 |
agglutinin-like sequence 3 |
Virulence factor |
MUTATION: als3/als3 mutant was defective in adhesion to both human umbilical vein endothelial cells (HUVEC) and buccal epithelial cells (BEC) [Ref7079:Kelly et al., 2004].
|
15255906
|
|
|
ASH1 |
Candida albicans SC5314 |
3641249
|
|
68477667
|
CaO19.5343 |
AACQ01000059 |
XP_717146 |
|
Virulence factor |
MUTATION: ash1p mutant is attenuated for virulence in a mouse model of disseminated candidiasis [Ref7084:Inglis and Johnson, 2002].
|
12446785
|
|
|
BGL2 |
Candida albicans |
|
532775
|
532776
|
|
|
AAA21151.1 |
beta-1,3 glucan transferase |
Virulence factor |
MUTATION: BGL2 mutant is attenuated in mice [Ref7085:Sarthy et al., 1997].
|
9043114
|
|
|
cahk1 |
Candida albicans |
|
2961065
|
2961066
|
|
|
AAC39451.1 |
histidine kinase 1 |
Virulence factor |
MUTATION: cahk1 mutant is attenuated in mice [Ref7086:Calera et al., 1999].
|
10417206
|
|
|
MNT1 |
Candida albicans SC5314 |
3636585
|
|
68468365
|
CaO19.1665 |
AACQ01000014 |
XP_721742 |
|
Virulence factor |
MUTATION: mnt1p mutant has reduced ability to adhere to human buccal epithelial cells and to rat vaginal epithelial cells, and is attenuated in guinea pig and mouse models of systemic candidosis [Ref7087:Buurman et al., 1998].
|
9636208
|
|
|
CMP65 |
Candida albicans SC5314 |
3643971
|
|
68483450
|
CaO19.9345 |
AACQ01000105 |
XP_714381 |
|
Virulence factor |
MUTATION: camp65 mutants are attenuated in mice [Ref7088:Sandini et al., 2007].
|
17217426
|
|
|
CaNAG1 |
Candida albicans |
|
|
13702164
|
|
|
|
|
Virulence factor |
MUTATION: CaNAG1 is moderately attenuated in mice [Ref7089:Yamada-Okabe et al., 2001].
|
11298769
|
|
|
CaNAG2 |
Candida albicans |
|
13702150
|
13702151
|
|
|
BAB43813.1 |
|
Virulence factor |
MUTATION: CaNAG2 is markedly attenuated in mice [Ref7089:Yamada-Okabe et al., 2001].
|
11298769
|
|
|
NAG3 |
Candida albicans SC5314 |
3646118
|
|
68487759
|
CaO19.9705 |
AACQ01000162 |
XP_712290 |
|
Virulence factor |
MUTATION: CaNAG3 mutant is attenuated in mice [Ref7090:Yamada-Okabe and Yamada-Okabe, 2002].
|
12076781
|
|
|
NAG4 |
Candida albicans SC5314 |
3645978
|
|
68487473
|
CaO19.2160 |
AACQ01000158 |
XP_712435 |
|
Virulence factor |
MUTATION: CaNAG4 mutant is attenuated in mice [Ref7090:Yamada-Okabe and Yamada-Okabe, 2002].
|
12076781
|
|
|
CaNAG5 |
Candida albicans |
|
13702156
|
13702157
|
|
|
BAB43816.1 |
|
Virulence factor |
MUTATION: CaNAG5 is markedly attenuated in mice [Ref7089:Yamada-Okabe et al., 2001].
|
11298769
|
|
|
NAG6 |
Candida albicans SC5314 |
3645961
|
|
68487455
|
CaO19.2151 |
AACQ01000158 |
XP_712426 |
|
Virulence factor |
MUTATION: CaNAG6 mutant is attenuated in mice [Ref7090:Yamada-Okabe and Yamada-Okabe, 2002].
|
12076781
|
|
|
CaNIK1 |
Candida albicans |
|
2911163
|
2911164
|
|
|
BAA24952.1 |
|
Virulence factor |
MUTATION: CaNik1 mutant is attenuated in mice [Ref7091:Yamada-Okabe et al., 1999].
|
10572127
|
|
|
NRG1 |
Candida albicans ATCC10261 |
|
12958591
|
12958592
|
|
|
AAK09366.1 |
Nrg1 |
Virulence factor |
MUTATION: Inactivation of CaNrg1 causes attenuated virulence in mice [Ref7092:Murad et al., 2001].
|
11532938
|
|
|
CaRAS1 |
Candida albicans wo1 |
|
6103364
|
6103365
|
|
|
AAF03566.1 |
Ras homolog type A |
Virulence factor |
MUTATION: CaRAS1 mutant is less resistant to phagocytosis and has reduced virulence in mice [Ref7093:Leberer et al., 2001].
|
11722734
|
|
|
CaSLN1 |
Candida albicans |
|
2911161
|
2911162
|
|
|
BAA24951.1 |
|
Virulence factor |
MUTATION: CaSLN1 mutant is attenuated in mice [Ref7091:Yamada-Okabe et al., 1999].
|
10572127
|
|
|
Cat1 |
Candida albicans ATCC 10261 |
|
3097875
|
3097876
|
|
|
AAC39448.1 |
catalase |
Virulence factor |
MUTATION: CAT1 null mutant is attenuated in mice for an intravenous infection model of disseminated candidiasis [Ref7094:Wysong et al., 1998].
|
9573075
|
|
|
TEC1 |
Candida albicans SC5314 |
3635261
|
|
68465521
|
CaO19.5908 |
AACQ01000003 |
XP_723122 |
|
Virulence factor |
MUTATION: The deletion of the CaTEC1 gene attenuates virulence of C. albicans in a systemic model of murine candidiasis [Ref7095:Schweizer et al., 2000].
|
11069668
|
|
|
TPS2 |
Candida albicans SC5314 |
3636892
|
|
68468955
|
CaO19.3038 |
AACQ01000017 |
XP_721536 |
|
Virulence factor |
MUTATION: CaTPS2 mutant is attenuated in a mouse model of systemic infection [Ref7096:Van et al., 2002].
|
11895938
|
|
|
CDC10 |
Candida albicans SC5314 |
3640905
|
|
68477055
|
CaO19.8183 |
AACQ01000055 |
XP_717505 |
|
Virulence factor |
MUTATION: cdc10 mutant is attenuated in mice [Ref7097:Warenda et al., 2003].
|
12819094
|
|
|
CDC11 |
Candida albicans SC5314 |
3647888
|
|
68491366
|
CaO19.5691 |
AACQ01000261 |
XP_710520 |
|
Virulence factor |
MUTATION: cdc11 mutant is attenuated in mice [Ref7097:Warenda et al., 2003].
|
12819094
|
|
|
CDC24 |
Candida albicans |
|
28192689
|
28192690
|
|
|
AAO25556.1 |
guanine nucleotide exchange factor Cdc24 |
Virulence factor |
MUTATION: cdc24 mutant is avirulent in mice [Ref7098:Bassilana et al., 2003].
|
12582118
|
|
|
ERK1 |
Candida albicans SC5314 |
3642789
|
|
68481001
|
CaO19.2886 |
AACQ01000083 |
XP_715542 |
|
Virulence factor |
MUTATION: disruption of the CEK1 gene adversely affects the growth of serum-induced mycelial colonies and attenuates virulence in a mouse model for systemic candidiasis [Ref7099:Csank et al., 1998].
|
9596738
|
|
|
chik1 |
Candida albicans ATCC366 |
|
3243088
|
3243089
|
|
|
AAC23929.1 |
histidine kinase |
Virulence factor |
MUTATION: Cos-1(chik1) mutant had sgnificantly reduced virulence in a systemic murine model of candidosis [Ref7100:Selitrennikoff et al., 2001].
|
11270409
|
|
|
CACHS3 |
Candida albicans IFO1060 |
|
218361
|
218362
|
|
|
BAA02707.1 |
chitin synthase III |
Virulence factor |
MUTATION: CHS3 mutant is significantly less virulent than the parental strain in both immunocompetent and immunosuppressed mice [Ref7101:Bulawa et al., 1995].
|
7479842
|
|
|
CHS7 |
Candida albicans SC5314 |
3639789
|
|
68474685
|
CaO19.9980 |
AACQ01000040 |
XP_718550 |
|
Virulence factor |
MUTATION: chs7 mutant had reduced virulence and a high clearance rate in mice [Ref7102:Sanz et al., 2005].
|
16079341
|
|
|
CLA4 |
Candida albicans |
|
2351701
|
2351702
|
|
|
AAB68613.1 |
CLA4 protein kinase homolog |
Virulence factor |
MUTATION: The gene deletions of CLA4 reduced colonization of the kidneys in infected mice and suppressed C. albicans virulence in the mouse model [Ref7103:Leberer et al., 1997].
|
9259554
|
|
|
CNA1 |
Candida albicans SC5314 |
3639328
|
|
68473784
|
CaO19.6033 |
AACQ01000035 |
XP_718995 |
|
Virulence factor |
MUTATION: cmp1 (CNA1)mutant is strongly attenuated in mice [Ref7104:Bader et al., 2003].
|
12933882
|
|
|
CNA1 |
Candida albicans SC5314 |
3639406
|
|
68473993
|
CaO19.13454 |
AACQ01000036 |
XP_718893 |
|
Virulence factor |
MUTATION: CNA mutant is attenuated in mice [Ref7105:Sanglard et al., 2003].
|
12753189
|
|
|
CNB1 |
Candida albicans SC5314 |
3636332
|
|
68467839
|
CaO19.11492 |
AACQ01000012 |
XP_722078 |
|
Virulence factor |
MUTATION: cnb1 mutants are attenuated in mice [Ref7106:Blankenship et al., 2003].
|
12796287
|
|
|
CPP1 |
Candida albicans |
|
349178
|
2947041
|
|
|
AAC05307.1 |
protein-tyrosine phosphatase |
Virulence factor |
MUTATION: CPP1 mutant is attenauted in a systemic mouse model [Ref7107:Csank et al., 1997].
|
9398674
|
|
|
UTR2 |
Candida albicans SC5314 |
3636747
|
|
68468620
|
CaO19.9240 |
AACQ01000013 |
XP_721629 |
|
Virulence factor |
MUTATION: csf4 (UTR2) mutant has reduction in adherence to mammalian cells and attenuated virulence in an immunocompetent mouse model of disseminated candidiasis [Ref7108:Alberti-Segui et al., 2004].
|
15042589
|
|
|
CSH1 |
|
|
33090238
|
33090239
|
|
|
AAP93915.1 |
cell surface hydrophobicity-associated protein |
Virulence factor |
MUTATION: Csh1 is attenuated in mucosal colonization in a vaginal infection model in mice [Ref7109:Singleton et al., 2005].
|
15766793
|
|
|
SHR3 |
Candida albicans SC5314 |
3646776
|
|
68489085
|
CaO19.10874 |
AACQ01000190 |
XP_711608 |
|
Virulence factor |
MUTATION: csh3 (SHR3) mutant is attenuated is avirulent in mice [Ref7110:MartÃnez and Ljungdahl, 2004].
|
14756779
|
|
|
CSP37 |
Candida albicans ATCC 26555 |
|
2149593
|
2149594
|
|
|
AAB66368.1 |
putative membrane protein |
Virulence factor |
MUTATION: Csp37 mutant is attenuated in mice [Ref7111:Sentandreu et al., 1997].
|
9244249
|
|
|
CST20 |
Candida albicans SC5314 |
3637661
|
|
68470348
|
CaO19.11717 |
AACQ01000021 |
XP_720678 |
|
Virulence factor |
MUTATION: CST20 mutant cells were less virulent in a mouse model for systemic candidiasis [Ref7112:Leberer et al., 1996].
|
8917571
|
|
|
DAC1 |
Candida albicans SC 5314 |
|
6137104
|
6137106
|
|
|
AAF04335.1 |
N-acetyl-glucosamine-6-phosphate deacetylase |
Virulence factor |
MUTATION: a DAC1/NAG1/HXK1 mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro [Ref7113:Singh et al., 2001].
|
11705974
|
|
|
ECM33 |
Candida albicans CAF2 |
|
53987032
|
53987033
|
|
|
AAV27296.1 |
GPI protein |
Virulence factor |
MUTATION: ecm33 mutant is avirulent in mice [Ref7114:Martinez-Lopez et al., 2004].
|
15470113
|
|
|
EFG |
Candida albicans ATCC10231 |
|
6468469
|
832907
|
|
|
CAA83640.1 |
putative transcription factor |
Virulence factor |
MUTATION: deltaefg1 mutant has reduced capacity to invade and injure endothelial cells [Ref7115:Phan et al., 2000].
|
10816502
|
|
|
FKH2 |
Candida albicans SC5314 |
3640536
|
|
68476229
|
CaO19.5389 |
AACQ01000050 |
XP_717764 |
|
Virulence factor |
MUTATION: fkh2 mutant are unable to damage human epithelial or endothelial cells in vitro [Ref7116:Bensen et al., 2002].
|
12455696
|
|
|
GAT1 |
Candida albicans |
|
31559063
|
31559064
|
|
|
AAP50501.1 |
nitrogen regulatory GATA-factor |
Virulence factor |
MUTATION: gat1 mutants are highly attenuated in a murine model of disseminated candidiasis [Ref7117:Limjindaporn et al., 2003].
|
14617156
|
|
|
GNA1 |
Candida albicans SC5314 |
3637397
|
|
68469902
|
CaO19.837 |
AACQ01000019 |
XP_720961 |
GTP cyclohydrolase subunit MoaC |
Virulence factor |
MUTATION: gna1 null mutant is significantly attenuated in mice [Ref7118:Mio et al., 2000].
|
10878139
|
|
|
GPI7 |
Candida albicans SC5314 |
3647663
|
|
68490911
|
CaO19.11547 |
AACQ01000242 |
XP_710743 |
|
Virulence factor |
MUTATION: gpi7 mutant is attenuated for virulence in mice and has reduced survival in the gastrointestinal environment of mice [Ref7119:Richard et al., 2002].
|
11994163
|
|
|
CLN3 |
Candida albicans SC5314 |
3639349
|
|
68473774
|
CaO19.6028 |
AACQ01000035 |
XP_718990 |
|
Virulence factor |
MUTATION: hgc1 (CLN3) mutant is has markedly reduced virulence in the kidneys of systemically infected mice [Ref7120:Zheng et al., 2004].
|
15071502
|
|
|
HOG1 |
Candida albicans SC5314 |
3637270
|
|
68469771
|
CaO19.8514 |
AACQ01000018 |
XP_721137 |
|
Virulence factor |
MUTATION: hog1 mutant is attenuated in mice [Ref7121:Alonso-Monge et al., 1999].
|
10322006
|
|
|
HWP1 |
Candida albicans SC5314 |
|
4028879
|
1915979
|
|
|
AAC96368.1 |
hyphal wall protein 1 |
Virulence factor |
MUTATION: Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice [Ref7122:Staab et al., 1999].
|
10066176
|
|
|
NAG5 |
Candida albicans SC5314 |
3646114
|
|
68487751
|
CaO19.9701 |
AACQ01000162 |
XP_712286 |
|
Virulence factor |
MUTATION: a DAC1/NAG1/HXK1(NAG5) mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro [Ref7113:Singh et al., 2001].
|
11705974
|
|
|
ICL1 |
Candida albicans SC5314 |
3646146
|
|
68487782
|
CaO19.6844 |
AACQ01000163 |
XP_712232 |
|
Virulence factor |
MUTATION: Candida albicans mutants lacking ICL1 are markedly less virulent in mice than the wild type [Ref7123:Lorenz and Fink, 2001].
|
11452311
|
|
|
INT1 |
Candida albicans SC5314 |
3637595
|
|
68470378
|
CaO19.11733 |
AACQ01000021 |
XP_720693 |
|
Virulence factor |
MUTATION: disruption of INT1 gene in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice [Ref7124:Gale et al., 1998].
|
9478896
|
|
|
IRO1 |
Candida albicans SC5314 |
3636648
|
|
68468453
|
CaO19.1715 |
AACQ01000013 |
XP_721786 |
|
Virulence factor |
MUTATION: IRO1 mutant is attenuated in mice [Ref7125:Chibana et al., 2005].
|
16237272
|
|
|
irs4 |
Candida albicans SC5314 |
3645650
|
|
68486800
|
CaO19.6953 |
AACQ01000148 |
XP_712754 |
|
Virulence factor |
MUTATION: an irs4 null mutant strain was associated with attenuated mortality, diminished tissue burdens, less extensive infections, impaired C. albicans hyphal formation and decreased kidney damage in mice [Ref7126:Badrane et al., 2005].
|
16151204
|
|
|
ker1 |
Candida albicans SC5314 |
3638466
|
|
68472127
|
CaO19.6763 |
AACQ01000029 |
XP_719859 |
|
Virulence factor |
MUTATION: ker1 mutant had attenuated virulence in systemic mouse infections [Ref7127:Galán et al., 2004].
|
15289560
|
|
|
Kex2 |
Candida albicans WO-1 |
|
2511731
|
2511732
|
|
|
AAB80929.1 |
proteinase |
Virulence factor |
MUTATION: kex2/kex2 mutants are highly attenuated in a mouse systemic infection model and persist within cultured macrophages for at least 24 h without causing damage [Ref7128:Newport et al., 2003].
|
12419804
|
|
|
GPT1 |
Candida albicans SC5314 |
3638247
|
|
68471625
|
CaO19.7922 |
AACQ01000026 |
XP_720119 |
|
Virulence factor |
MUTATION: C. albicans KRE5 homozygous mutant strains exhibit a 50% reduction in adhesion to human epithelial cells and are completely avirulent in a mouse model of systemic infection [Ref7129:Herrero et al., 2004].
|
15590817
|
|
|
LIG4 |
Candida albicans SC5314 |
3642986
|
|
68481400
|
CaO19.5798 |
AACQ01000087 |
XP_715339 |
|
Virulence factor |
MUTATION: deletion of one or both copies of LIG4 resulted in attenuation of virulence in a murine model of candidiasis [Ref7130:Andaluz et al., 2001].
|
11119499
|
|
|
MAD2 |
Candida albicans SC5314 |
3644665
|
|
68484757
|
CaO19.8642 |
AACQ01000120 |
XP_713690 |
|
Virulence factor |
MUTATION: mad2 mutant is attenuated in mice [Ref7131:Bai et al., 2002].
|
12100546
|
|
|
MDR |
Candida albicans B792 |
|
2516
|
2517
|
|
|
CAA37820.1 |
|
Virulence factor |
MUTATION: CaMDR1 mutant is attenuated in virulence in mouse kidneys [Ref7132:Becker et al., 1995].
|
7591094
|
|
|
MDS3 |
Candida albicans BWP17 |
|
27413016
|
27413017
|
|
|
AAN77869.1 |
Mds3p |
Virulence factor |
MUTATION: mds3 mutant is attenuated in mice [Ref7133:Davis et al., 2002].
|
12524333
|
|
|
SUR1 |
Candida albicans SC5314 |
3644089
|
|
68483590
|
CaO19.4077 |
AACQ01000110 |
XP_714248 |
|
Virulence factor |
MUTATION: mit1(SUR1) mutant was less virulent during both the acute and chronic phases of systemic infection in mice [Ref7134:Mille et al., 2004].
|
15347680
|
|
|
MKC1 |
Candida albicans 1001 (ATCC 64385) |
|
619449
|
619450
|
|
|
CAA54129.1 |
MAP kinase Mkc1 |
Virulence factor |
MUTATION: MKC1 mutant is attenuated in mice [Ref7135:Diez-Orejas et al., 1997].
|
9009353
|
|
|
MLT1 |
Candida albicans SS |
|
19549336
|
19549337
|
|
|
AAD51594.2 |
MRP-like transporter |
Virulence factor |
MUTATION: MLT1 mutant is attenuated in a mouse peritonitis model [Ref7136:Theiss et al., 2002].
|
11929516
|
|
|
mnt2 |
Candida albicans Cai-4 |
|
1359535
|
1359536
|
|
|
CAA61538.1 |
putative mannosyl transferase |
Virulence factor |
MUTATION: mnt2 mutant is has reduced adherence to human buccal epithelial cells [Ref7137:Munro et al., 2005].
|
15519997
|
|
|
NAG1 |
Candida albicans SC5314 |
3646116
|
6137104
|
68487755
|
CaO19.9703 |
AACQ01000162 |
XP_712288 |
N-acetyl-glucosamine-6-phosphate deacetylase |
Virulence factor |
MUTATION: a DAC1/NAG1/HXK1 mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro [Ref7113:Singh et al., 2001].
|
11705974
|
|
|
NOT4 |
Candida albicans SC5314 |
|
28373259
|
28373260
|
|
|
AAF66693.2 |
NOT4p |
Virulence factor |
MUTATION: not4 mutant is attenuated in mice [Ref7138:Krueger et al., 2004].
|
14702416
|
|
|
NOT5 |
Candida albicans SC5314 |
3640763
|
|
68476703
|
CaO19.5107 |
AACQ01000053 |
XP_717644 |
|
Virulence factor |
MUTATION: NOT5 mutant had reduced adherence to epithelial cells and has attenuated virulence in mice [Ref7139:Cheng et al., 2003].
|
14500538
|
|
|
PDE2 |
Candida albicans SC5314 |
3636877
|
|
68468825
|
CaO19.2972 |
AACQ01000017 |
XP_721471 |
|
Virulence factor |
MUTATION: pde2 mutant is attenuated in mice [Ref7140:Wilson et al., 2007].
|
17614954
|
|
|
PHR1 |
Candida albicans SC5314 |
|
857671
|
857672
|
|
|
AAA68196.1 |
pH responsive protein |
Virulence factor |
MUTATION: phr1 mutant is attenuated in mice [Ref7141:Ghannoum et al., 1995].
|
7591097
|
|
|
PLB1 |
Candida albicans SC5314 |
|
3169706
|
3445504
|
|
|
AAC61890.1 |
phospholipase B precursor |
Virulence factor |
MUTATION: Plb1 mutant is attenuated in mice [Ref7142:Mukherjee et al., 2001].
|
11535799
|
|
|
SPO14 |
Candida albicans SC5314 |
3645329
|
|
68486156
|
CaO19.1161 |
AACQ01000137 |
XP_713028 |
|
Virulence factor |
MUTATION: pld1(SPO14) mutants are unable to survive in internal organs after intravenous challenge, and are not lethal for immunodeficient mice after oral challenge [Ref7143:Dolan et al., 2004].
|
15552646
|
|
|
PMR1 |
Candida albicans SC5314 |
3638043
|
|
68471207
|
CaO19.7089 |
AACQ01000024 |
XP_720380 |
|
Virulence factor |
MUTATION: pmr1 mutant was severely attenuated in virulence in a murine model of systemic infection [Ref7144:Bates et al., 2005].
|
15843378
|
|
|
PMT1 |
Candida albicans SC5314 |
3641393
|
|
68477979
|
CaO19.5171 |
AACQ01000060 |
XP_716993 |
|
Virulence factor |
MUTATION: Homozygous pmt1 mutants were avirulent in a mouse model of systemic infection, while heterozygous PMT1/pmt1 strains showed reduced virulence [Ref7145:Timpel et al., 1998].
|
9694829
|
|
|
PMT2 |
Candida albicans SC5314 |
3638538
|
|
68472223
|
CaO19.6812 |
AACQ01000028 |
XP_719907 |
|
Virulence factor |
MUTATION: pmt2 mutant has attenuated virulence in a mouse model of hematogenously disseminated candidiasis (HDC) [Ref7146:Rouabhia et al., 2005].
|
16040968
|
|
|
PMT4 |
Candida albicans SC5314 |
3644096
|
|
68483654
|
CaO19.4109 |
AACQ01000110 |
XP_714280 |
|
Virulence factor |
MUTATION: pmt4 mutant is attenuated in mice [Ref7147:Prill et al., 2005].
|
15659169
|
|
|
pmt5 |
Candida albicans SC5314 |
3639011
|
|
68473011
|
CaO19.7549 |
AACQ01000032 |
XP_719311 |
|
Virulence factor |
MUTATION: pmt5 mutant was less virulent in engineered human oral mucosa (EHOM) and in a mouse model of hematogenously disseminated candidiasis (HDC) [Ref7146:Rouabhia et al., 2005].
|
16040968
|
|
|
PMT6 |
Candida albicans 1006 |
|
6561138
|
6561139
|
|
|
AAF16867.1 |
protein mannosyltransferase |
Virulence factor |
MUTATION: pmt6 mutant has reduced adherence to endothelial cells and attenuated virulence in mice [Ref7148:Timpel et al., 2000].
|
10809683
|
|
|
RBT1 |
Candida albicans |
|
9963981
|
9963982
|
|
|
AAG09787.1 |
repressed by TUP1 protein 1 |
Virulence factor |
MUTATION: rbt1 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model [Ref7149:Braun et al., 2000].
|
10978273
|
|
|
RBT4 |
Candida albicans |
|
9963985
|
9963986
|
|
|
AAG09789.1 |
repressed by TUP1 protein 4 |
Virulence factor |
MUTATION: rbt4 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model [Ref7149:Braun et al., 2000].
|
10978273
|
|
|
RHO1 |
Candida albicans SC5314 |
3642557
|
|
68480453
|
CaO19.10362 |
AACQ01000079 |
XP_715825 |
|
Virulence factor |
MUTATION: RHO1 mutant is unable to colonize murine kidneys and cause disease in mice [Ref7150:Smith et al., 2002].
|
12702298
|
|
|
RIM101 |
Candida albicans SC5314 |
3643280
|
|
68482059
|
CaO19.7247 |
AACQ01000092 |
XP_715047 |
|
Virulence factor |
MUTATION: rim101 mutant is attenuated in a mouse model of hematogenously disseminated systemic candidiasis [Ref7151:Davis et al., 2000].
|
10992507
|
|
|
RIM8 |
Candida albicans SC5314 |
3639342
|
|
68473896
|
CaO19.6091 |
AACQ01000036 |
XP_719051 |
|
Virulence factor |
MUTATION: rim8 mutant is attenuated in a mouse model of hematogenously disseminated systemic candidiasis [Ref7151:Davis et al., 2000].
|
10992507
|
|
|
RSR1 |
Candida albicans B792 |
|
1203833
|
1203834
|
|
|
AAB81286.1 |
Rsr1p |
Virulence factor |
MUTATION: RSR1 mutant is attenuated in mice [Ref7152:Yaar et al., 1997].
|
9308185
|
|
|
SAP1 |
Candida albicans SC5314 |
3640256
|
|
68475693
|
CaO19.5714 |
AACQ01000046 |
XP_718053 |
|
Virulence factor |
MUTATION: sap1 mutant is attenuated in mice and guinea pigs [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP2 |
Candida albicans CAI4 |
|
20378981
|
20378982
|
|
|
AAM21050.1 |
secreted aspartic proteinase 2 |
Virulence factor |
MUTATION: sap2 mutant is attenuated in mice and guinea pigs [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP3 |
Candida albicans SC5314 |
3635197
|
|
68465697
|
CaO19.6001 |
AACQ01000004 |
XP_723210 |
|
Virulence factor |
MUTATION: sap3 mutant is attenuated in mice and guinea pigs [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP4 |
Candida albicans SC5314 |
3640365
|
|
68475830
|
CaO19.13139 |
AACQ01000046 |
XP_717988 |
|
Virulence factor |
MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP5 |
Candida albicans SC5314 |
3639268
|
|
68473645
|
CaO19.5585 |
AACQ01000034 |
XP_719147 |
|
Virulence factor |
MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP6 |
Candida albicans SC5314 |
3639229
|
|
68473561
|
CaO19.5542 |
AACQ01000034 |
XP_719105 |
|
Virulence factor |
MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice [Ref7153:Hube et al., 1997].
|
9284116
|
|
|
SAP7 |
Candida albicans SC5314 |
3644735
|
|
68484925
|
CaO19.8376 |
AACQ01000123 |
XP_713601 |
|
Virulence factor |
MUTATION: sap7 mutant is attenuated in an intravenous model of systemic candidiasis in mice [Ref7154:Taylor et al., 2005].
|
16177393
|
|
|
ARN1 |
Candida albicans SC5314 |
3642307
|
|
68479941
|
CaO19.2179 |
AACQ01000076 |
XP_716020 |
|
Virulence factor |
MUTATION: sit1(ARN1) mutant was defective in infection of a reconstituted human epithelium as a model for human oral mucosa [Ref7155:Heymann et al., 2002].
|
12183576
|
|
|
SIT4 |
Candida albicans SC5314 |
3647982
|
|
68491579
|
CaO19.12667 |
AACQ01000273 |
XP_710419 |
|
Virulence factor |
MUTATION: sit4 mutant is attenuated in mice [Ref7156:Lee et al., 2004].
|
14731272
|
|
|
SKN7 |
Candida albicans SC5314 |
3641499
|
|
68478255
|
CaO19.8586 |
AACQ01000062 |
XP_716869 |
|
Virulence factor |
MUTATION: skn7 mutant is mildly attenuated in mice [Ref7157:Singh et al., 2004].
|
15039366
|
|
|
sod1 |
Candida albicans |
|
3005096
|
3005097
|
|
|
AAC12872.1 |
Cu,Zn-superoxide dismutase |
Virulence factor |
MUTATION: sod1 mutant had increased susceptibility to macrophage attack and had attenuated virulence in mice [Ref7158:Hwang et al., 2002].
|
12427960
|
|
|
SOD5 |
Candida albicans SC5314 |
3638702
|
|
68472625
|
CaO19.9607 |
AACQ01000030 |
XP_719631 |
|
Virulence factor |
MUTATION: sod5 mutant is attenuated in mice [Ref7159:Martchenko et al., 2004].
|
14617819
|
|
|
SPA2 |
Candida albicans SC5314 |
3646770
|
|
68489072
|
CaO19.13719 |
AACQ01000192 |
XP_711649 |
|
Virulence factor |
MUTATION: spa2Delta exhibited no virulence in the mouse systemic candidiasis model [Ref7160:Zheng et al., 2003].
|
12940995
|
|
|
SPT3 |
Candida albicans SC5314 |
3638977
|
|
68473155
|
CaO19.7622 |
AACQ01000032 |
XP_719383 |
|
Virulence factor |
MUTATION: spt3 mutant is avirulent in mice [Ref7161:Laprade et al., 2002].
|
12072450
|
|
|
SSN6 |
Candida albicans ATCC10231 |
|
18767667
|
18767668
|
|
|
AAL54912.2 |
putative transcriptional repressor |
Virulence factor |
MUTATION: ssn6/ssn6 mutant is avirulent in mice [Ref7162:Hwang et al., 2003].
|
12581357
|
|
|
CaTOP1 |
Candida albicans |
|
|
1762119
|
|
|
|
topoisomerase I |
Virulence factor |
MUTATION: a single gene knockout TOP1 mutant is attenuated in mice [Ref7163:Jiang et al., 1997].
|
9043115
|
|
|
TPK2 |
Candida albicans strain 1161 |
|
7578501
|
7578502
|
|
|
AAF64072.1 |
protein kinase A |
Virulence factor |
MUTATION: tpk2/tpk2 mutant has reduced capacity to invade and damage oral epithelial cells and is also attenuated in mice [Ref7164:Park et al., 2005].
|
15760450
|
|
|
TPS1 |
Candida albicans SC5314 |
3646212
|
|
68487926
|
CaO19.13961 |
AACQ01000186 |
XP_712180 |
|
Virulence factor |
MUTATION: Mice inoculated with 10(6) CFU of the tps1/tps1 mutant did not show visible symptoms of infection 16 days after inoculation, while those similarly inoculated with wild-type cells were dead 12 days after inoculation [Ref7165:Zaragoza et al., 1998].
|
9683476
|
|
|
TUP1 |
Candida albicans SC5314 |
3639369
|
|
68473930
|
CaO19.6109 |
AACQ01000035 |
XP_719068 |
|
Virulence factor |
MUTATION: tup1 mutant is significantly reduced in the ability to invade and injure endothelial cells [Ref7115:Phan et al., 2000].
|
10816502
|
|
|
VMA7 |
Candida albicans SC5314 |
3637217
|
|
68469597
|
CaO19.8424 |
AACQ01000019 |
XP_721050 |
|
Virulence factor |
MUTATION: vma7 null mutant is avirulent in a mouse model of systemic candidiasis [Ref7166:Poltermann et al., 2005].
|
15870472
|
|
|
VPS4 |
Candida albicans SC5314 |
3637703
|
|
68470797
|
CaO19.4339 |
AACQ01000022 |
XP_720644 |
|
Virulence factor |
MUTATION: vps4 mutant is greatly attenuated for virulence in a mouse model of disseminated candidiasis [Ref7167:Lee et al., 2009].
|
18814053
|
|
|
YHB1 |
Candida albicans SC5314 |
3647353
|
|
68490250
|
CaO19.3707 |
AACQ01000217 |
XP_711046 |
|
Virulence factor |
MUTATION: CaYHB1 mutant is still lethal in mice but has reduced virulence compared to the wild type [Ref7168:Ullmann et al., 2004].
|
15189992
|
|
|
YVH1 |
Candida albicans SC5314 |
3643218
|
|
68481871
|
CaO19.4401 |
AACQ01000091 |
XP_715177 |
|
Virulence factor |
MUTATION: yvh1 has attenuated virulence in mice [Ref7169:Hanaoka et al., 2005].
|
16000712
|
|
|
UPC2 |
|
|
|
556911682
|
|
|
|
transcription factor Upc2 |
Virulence factor |
Deletion of the transcription factors UPC2 (involved in the control of ERG11) of Candida albicans results in the significant attenuation of virulence in mice, and had a negative impact on fitness, results in the epidemiology of antifungal resistance.[Ref7534:Lohberger et al., 2014] |
24243794
|
|
|
NCE102 |
Candida albicans SC5314 |
3635267
|
|
68465619
|
CaO19.5960 |
AACQ01000004 |
XP_723171 |
|
Virulence factor |
Nce102 is implicated in regulating membrane structure and function.The nce102 mutant decreased virulence in mice. The results showed that Nce102 involved in a regulate pathways that regulate morphogenesis and pathogenesis of C. albicans. [Ref7536:Douglas et al., 2013] |
24281718
|
|
|
MNN21 |
Candida albicans SC5314 |
3648131
|
|
68491898
|
CaO19.8625 |
AACQ01000293 |
XP_710268 |
|
Virulence factor |
In Candida albicans, the mannosyltransferase, Mnn2, gene family is comprised of six members (MNN2, MNN21, MNN22, MNN23, MNN24 and MNN26) .Deletion of all MNN2 gene family members increased the average survival of the moth larvae by 50%, and the sextuple mutant was attenuated in virulence with 100% of mice surviving infection with the sextuple mutant.[Ref7538:Hall et al., 2013] |
23633946
|
|
|
TOP2 |
Candida albicans SC5314 |
3642722
|
|
68480866
|
CaO19.10391 |
AACQ01000083 |
XP_715586 |
DNA topoisomerase II similar to S. cerevisiae TOP2 |
Virulence factor |
the TOP2 gene played an important role in pathogenicity of C.albicans. The absence of TOP2 gene increased hypha formation, proteinases and phospholipase secretory activities, and so increased pathogenicity of C. albicans. [Ref7539:Zheng and Yu, 2012] |
22203422
|
|
|
SPF1 |
Candida albicans SC5314 |
3646573
|
|
68488657
|
CaO19.30 |
AACQ01000181 |
XP_711837 |
potential ER membrane P-type ATPase |
Virulence factor |
Spf1is a putative ER-localized P-type calcium ATPase in C. albicans. Deletion of SPF1 severely attenuated the virulence of Candida albicans in the mouse model. In contrast with the wild-type, SPF1 mutant produced little biomass and is defective for invasion in mouse kidneys. [Ref7540:Yu et al., 2012] |
22745267
|
|
|
PGA13 |
Candida albicans _SC5314 |
|
|
|
|
|
|
|
Virulence factor |
PGA13 encoding a GPI protein in Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. Compared to the parental strain, the homozygous pga13Δ mutant processed shorter and irregular hyphae. All pga13Δ mutants (homo-, heterozygous and reintegrant) showed a sharply attenuated virulence in a mouse model. Above all, these results indicated that Pga13 is a determinant of C. albicans pathogenicity.[Ref7541:Gelis et al., 2012] |
22343036
|
|
|
PGA29 |
Candida albicans |
|
|
|
|
|
|
|
Virulence factor |
The pga29 deletion mutant is less virulent, and infection of reconstituted human epithelium with the pga29 mutant results in a diminished induction of proinflammatory cytokines, such as GM-CSF, TNF, IL-6 and IL-8. Deletion of PGA29 leads to reduced tissue invasion of infected reconstituted human epithelium, and is slightly reduced in virulence in a mouse model of haematogenous disseminated candidiasis compared to the WT strain. [Ref7542:de et al., 2010] |
20533408
|
|
|
HSP104 |
Candida albicans SC5314 |
3642228
|
|
68479564
|
CaO19.13747 |
HC749752 |
XP_716146 |
|
Virulence factor |
the hsp104Δ mutation Decreased the virulence of Candida albicans in the Caenorhabditis elegans infection model. Worms infected with the homozygous mutant showed a clearly increase in survival relative to animals infected with the wild-type Candida albicans strains. The results show a temperature-independent role for Hsp104 in support of Candida albicans virulence, in addition to its key role in governing thermotolerance.[Ref7543:Fiori et al., 2012]
|
22635920
|
|
|
DUR1,2 |
Candida albicans SC5314 |
3644729
|
|
68484977
|
CaO19.8402 |
AACQ01000123 |
XP_713627 |
|
Virulence factor |
A dur1,2Δ/dur1,2Δ mutant significantly decreased in virulence in a mouse model than the wild-type strain, showing significantly higher survival rate, better renal function, and decreased and less sustained fungal colonization in kidney and brain.[Ref7544:Navarathna et al., 2012] |
23144764
|
|
|
DUR31 |
Candida albicans SC5314 |
3644730
|
|
68484979
|
CaO19.8403 |
AACQ01000122 |
XP_713628 |
|
Virulence factor |
Homozygous knockout mutants with DUR31 in Candida albicans elicited the strongest reduction in pathogenicity which caused significantly less damage in human oral epithelium.[Ref7545:Mayer et al., 2012] |
22438810
|
|
|
SEF1 |
Candida albicans SC5314 |
3644909
|
|
68485287
|
CaO19.11237 |
AACQ01000127 |
XP_713477 |
|
Virulence factor |
Sef1 is critical for virulence and competitive infection in BALB/c mice. Sef1-deleted mutant was significantly outcompeted by wild type C. albicans in mouse kidneys.[Ref7546:Chen et al., 2011] |
21843869
|
|
|
HSF (CTA8) |
Candida albicans SC5314 |
3634947
|
|
68464767
|
CaO19.4775 |
AACQ01000001 |
XP_723461 |
|
Virulence factor |
C. albicans mutant which unable to activate Hsf1 gene display attenuated virulence in mice with systemic candidiasis. The HSF1 mutant displayed significantly reduced fungal burdens and outcome scores compared with the control strains.[Ref7547:Nicholls et al., 2011] |
20817114
|
