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MNT1

Victor ID 4592
Gene Name MNT1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3636585
NCBI Protein GI 68468365
Locus Tag CaO19.1665
Genbank Accession AACQ01000014
Protein Accession XP_721742
Taxonomy ID 237561
Chromosome No 3
Gene Starting Position 125726
Gene Ending Position 127021
Gene Strand (Orientation) +
Protein pI 6.89
Protein Weight 48315.49
Protein Length 431
DNA Sequence 
>gi|68468490:125726-127021 Candida albicans SC5314 chromosome 3 Ctg19-10123, whole genome shotgun sequence
AATGGCTTCTACCAGATCGAATGCTCGTTTGATTAGATTTGGGATCTTTGCCCTTGTTTTAATAGGATGT
GGCTATATCCTTACAAGAGGCTCATCATTCCAACCTCCAAATTATCAACAAACACAATCACCCGCCGCTC
ATGAAAAACAGACCGGTAATGTTGCTGCTGGAGGTGGTGCTGGTTCAGGTTCCGCAGGAGCTCAAGTTCC
ATTAGGCAAAAATAGAGGTCCAATACCAAAAGCAATTATGGGAGCTGGTGAAGGTGGTAGTGATGCTCCG
GTTCCTCAACAAGATATTCCTGATAGTTATACCCTCAATGACAAAATTAAGGCTACATTTGTCACTTTGG
CCCGTAACTCTGATTTATATTCTTTAGCTGAATCAATTAGACACGTTGAAGATCGTTTCAATAAGAAATT
CCATTATGATTGGGTTTTCCTCAATGATGAAGAATTCAATGATGAATTTAAAGAAACTGTTGGTAGTTTA
GTTAGTGGTAACACTAAATTTGGTTTGATTCCAAAGGAACATTGGTCATATCCTCCATGGATTGATCAAG
AAAAAGCTGCTTTAGTCCGTGAACAAATGAGAGAAAAGAAGATTATTTATGGTCATTCTGAATCTTATCG
TCACATGTGTAGATTTGAAAGTGGGTTTTTCTGGAGGCAAGAAATTTTAAACGATTATGATTACTATTGG
AGAGTTGAACCAGATATCAAATTATATTGTGATATTGATTATGATATCTTTAAATGGATGAAAGATAATA
ATAAAGATTATGCATTCACTATTTCCTTACCAGAATATAAAGAAACCATTCCTACTTTATGGGACACTAC
TAAAGAATTTATTGAAAAAAACCCACAATATTTGGCTCAAAATAACTTGATGGATTGGGTTTCTGACGAT
AAAGGTCAAACTTATAATGGTTGTCATTTCTGGTCCAATTTTGAAATTGGTTCTTTGGCATTTTGGAGAA
GTGAAGCTTACAGAAAATATTTTGAACATTTAGATAAAGCTGGTGGATTCTTTTATGAAAGATGGGGTGA
TGCTCCAGTTCATTCCATTGCTGCAGCATTATTTTTACCAAGAGAAAAAATCCATTTCTTTGAAGATGTT
GGTTATTATCATGTTCCATTTACCAATTGCCCAGTTGATAAAGAAGTCAGAAAGGCAAGAAATTGTAATT
GTGATCCTAACAAAGATTTTACTTGGAGAGGCTATTCTTGTACTACCAAATATTACACTTTGAATAATTT
CAAAAGACAAAAGGGTTGGGAAAAGTACACTGCTTA
Protein Sequence 
>gi|68468365|ref|XP_721742.1| hypothetical protein CaO19.1665 [Candida albicans SC5314]
MASTRSNARLIRFGIFALVLIGCGYILTRGSSFQPPNYQQTQSPAAHEKQTGNVAAGGGAGSGSAGAQVP
LGKNRGPIPKAIMGAGEGGSDAPVPQQDIPDSYTLNDKIKATFVTLARNSDLYSLAESIRHVEDRFNKKF
HYDWVFLNDEEFNDEFKETVGSLVSGNTKFGLIPKEHWSYPPWIDQEKAALVREQMREKKIIYGHSESYR
HMCRFESGFFWRQEILNDYDYYWRVEPDIKLYCDIDYDIFKWMKDNNKDYAFTISLPEYKETIPTLWDTT
KEFIEKNPQYLAQNNLMDWVSDDKGQTYNGCHFWSNFEIGSLAFWRSEAYRKYFEHLDKAGGFFYERWGD
APVHSIAAALFLPREKIHFFEDVGYYHVPFTNCPVDKEVRKARNCNCDPNKDFTWRGYSCTTKYYTLNNF
KRQKGWEKYTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mnt1p mutant has reduced ability to adhere to human buccal epithelial cells and to rat vaginal epithelial cells, and is attenuated in guinea pig and mouse models of systemic candidosis (Buurman et al., 1998).
References
Buurman et al., 1998: Buurman ET, Westwater C, Hube B, Brown AJ, Odds FC, Gow NA. Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 1998; 95(13); 7670-7675. [PubMed: 9636208].