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RBT4

Victor ID 4670
Gene Name RBT4
Sequence Strain (Species/Organism) Candida albicans
NCBI Nucleotide GI 9963985
NCBI Protein GI 9963986
Protein Accession AAG09789.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name repressed by TUP1 protein 4
Protein Note plant pathogenesis-related protein; predicted signal sequence indicates secretion; similar to Saccharomyces cerevisiae PRY1-3 protein family and to the plant Pr1a family of pathogenesis-related protiens that are expressed upon fungal infection; deletion of this gene causes no morphological or other plate phenotypes but appears to impair virulence in mice and rabbits; Rbt4p
DNA Sequence 
>gi|9963985|gb|AF254144.1| Candida albicans repressed by TUP1 protein 4 (RBT4) gene, complete cds
TATTCATAGGACGGGGGAAAAATTCTTTTCTTGTGCTACCACCACCAGTGGTATGACTTCGCTTCGCCCT
GCCAGGATTTTCAAAGTGTTTATTTTATTTTTTTTTGAAAGTTCTACCGCCTTATACAATTCACGCATTC
CAACTGTACTCAAAACGTCGCACAAAAAAGGGGGACAGAATATTTTATTTCATTCAACCTTAAATTGTTG
TTTTTCTATTGTTCCCCTTTTTGTGACACGCAAACCAATAATAATAAAACAATATGTACCTTTTCTTACT
TTGTCTTTCTCTTTATTCTCTCTTTATGTTTCGAAACCAGCCAAACAATTGTTTTTATTTCCCCCTTTAG
TGTATGTTATGTTATGTTTTTTTCTCTTTTTATTATTATTCTCCTAAGAAAAAAAAAGATCGCCAAAGAT
TATATAAATAGGTATTAGAATTCCCATCAACTGTCCATCCAAATTCTTTCTTTTATTCCTCATCAACATA
CAATATCAAAATTATTTAACAACTGAGTTTTAAATCCAACTTTTTTGTCGTTCCTTACAAACTTTTTACT
CAACTTTAGTCACTCCTTTACCCCATCTTTATTCAATTTTTTTATTGTTAAACTTTTAAACTTTCAAACT
TTCGAACTTTCCATCATTATCAAATTATTCTAGAAATGAAGTTTTCTCAAGTTGCCACTACTGCTGCCAT
TTTTGCTGGTTTAACCACTGCTGAAATCGCCTATGTCACCCAGACTCGTGGTGTTACTGTTGGTGAAACT
GCCACCGTTGCTACAACTGTTACCGTTGGTGCAACTGTCACTGGTGGTGACCAAGGTCAAGATCAAGTTC
AACAATCAGCTGCTCCAGAAGCTGGTGATATTCAACAATCAGCTGTTCCAGAAGCTGATGATATCCAACA
ATCAGCTGTTCCAGAAGCTGAACCCACTGCCGATGCTGATGGTGGTAATGGTATTGCAATTACCGAAGTC
TTTACCACTACCATTATGGGTCAAGAGATTGTTTATTCCGGTGTTTATTACAGTTATGGTGAAGAACATA
CCTATGGAGACGTTCAAGTTCAAACCCTCACTATTGGGGGTGGCGGCTTCCCTTCAGATGACCAATATCC
TACAACTGAAGTTTCTGCTGAGGCTAGTCCATCTGCTGTTACTACTTCTTCTGCTGTTGCTACTCCTGAC
GCCAAAGTCCCAGACTCTACTAAAGACGCTTCTCAACCCGCTGCTACTACAGCTAGTGGCTCCTCTTCTG
GTAGTAATGACTTTAGTGGTGTTAAAGATACCCAATTTGCTCAACAAATCTTGGATGCTCACAACAAAAA
ACGTGCTAGACATGGTGTTCCAGATTTGACTTGGGATGCTACTGTTTACGAATATGCTCAAAAATTTGCT
GATCAATACAGTTGTTCTGGTAACTTGCAACACTCTGGTGGTAAATATGGTGAAAACTTGGCTGTTGGTT
ATGCTGATGGTGCTGCTGCTCTTCAAGCTTGGTACGAAGAAGCTGGTAAGGACGGATTAAGCTACAGTTA
CGGTTCTTCTTCTGTATACAACCATTTCACTCAAGTTGTCTGGAAATCAACCACCAAACTTGGTTGTGCT
TACAAGGATTGTCGTGCTCAAAACTGGGGATTATACGTTGTTTGTTCCTACGACCCAGCTGGTAACGTTA
TGGGTACTGATCCAAAGACTGGTAAATCTTATATGGCTGAAAATGTCTTGAGACCACAATAAATGATTTA
TTAGACCTAGTCCTTGTCCATGTCCTACCTTCCTCCCCCCTTTAGATTTATTTTTTATTAACTTTTCAGT
TTTACCTTTTTTTTTTGGGATTGTTTGAAATTTAACGCATAGGCCCCTTATGATAAGTGGGTATTCAAAC
TTTATCTTGGTTGTTTTATTGTTATTACTATAATTTTTCTTTTTTTTGGGATTTTTCACTTATTATATTG
TTTTGGAAGTCATTGGATTATTAAACATACAATTTTGTTATTTTTACTTTCATCATTATATTTGTTTTTG
GGTTTGTTTTTAACATTTCTTATTTGTTCATACCCCATGTTTCTGTATATTTTTTTCTATCTCTATCTCT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: rbt4 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model (Braun et al., 2000).
References
Braun et al., 2000: Braun BR, Head WS, Wang MX, Johnson AD. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics. 2000; 156(1); 31-44. [PubMed: 10978273].